Xiaosu Wu
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View article: Structural basis for pharmacological modulation of the TRPC6 channel
Structural basis for pharmacological modulation of the TRPC6 channel Open
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treatin…
View article: Sorption of cadmium by rice husk char, bamboo char, and coconut shell char in aqueous solutions
Sorption of cadmium by rice husk char, bamboo char, and coconut shell char in aqueous solutions Open
Cadmium (Cd) is a byproduct of zinc production. It has a high solubility, mobility and biological accumulation leading to a risk of bone and kidney damage after long-term exposure. Sorption is an effective method to treat Cd-contaminated w…
View article: Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate Open
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose home…
View article: Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia
Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia Open
Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma…