Explanipedia

SARS-CoV-2 rebound and post-acute mortality and hospitalization among patients admitted with COVID-19: cohort study Open

Ka Chun Chong, Yuchen Wei, Katherine Min Jia, Christopher Boyer, Guozhang Lin , et al. · 2025

Recent investigations have demonstrated a relationship between the persistence of SARS-CoV-2 and post-COVID-19 conditions. Building upon a potential connection between SARS-CoV-2 persistence and early virologic rebound, we examine the asso…

Short- and long-term comparative effectiveness of nirmatrelvir/ritonavir and molnupiravir in asthma patients: a cohort study Open

Guozhang Lin, Yuchen Wei, Zihao Guo, Huwen Wang, Kate Ching Ching Chan , et al. · 2025

Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID-19 outcomes among outpatients: a target trial emulation investigation Open

Yuchen Wei, Christopher Boyer, Katherine Min Jia, Guozhang Lin, Huwen Wang , et al. · 2025

Limited studies compared the effectiveness of nirmatrelvir/ritonavir and molnupiravir against a control group on post-COVID-19 conditions. Our study examined the association of nirmatrelvir/ritonavir and molnupiravir with post-acute mortal…

The epidemiological study of family-based Helicobacter pylori screening and its benefits: a cross-sectional study Open

A. Huang, Cong He, Jifang Sheng, Xiaoting Jiang, Nianshuang Li , et al. · 2025

This study aimed to manage Helicobacter pylori (H. pylori) infection through a family-centered approach. It conducted a two-year follow-up on infected individuals' family members in Yichun, Jiangxi, China, to gain comprehensive insights in…

COVID-19 vaccination modified the effect of nirmatrelvir–ritonavir on post-acute mortality and rehospitalization: a retrospective cohort study Open

Huwen Wang, Yuchen Wei, Guozhang Lin, Christopher Boyer, Katherine Min Jia , et al. · 2024

While previous research examined coronavirus disease 2019 (COVID-19) antiviral-vaccine interactions through exploratory subgroup analysis, none specifically designed for examining this interaction or its impact on post-acute outcomes. This…

Environmental factors, influenza activity, and sepsis: An analysis of 22-year hospital admission data Open

Guozhang Lin, Conglu Li, Xiaoting Jiang, Yuchen Wei, Ka Chun Chong · 2024

Exposure to cold temperature and influenza infections increased the risk of myocarditis hospitalization: A time-series analysis Open

Wenxiao Zheng, Guozhang Lin, Conglu Li, Xiaoting Jiang, Yuchen Wei , et al. · 2024

Association between meteorological variations and the superspreading potential of SARS-CoV-2 infections Open

Ka Chun Chong, Shi Zhao, Chi Tim Hung, Katherine Min Jia, Janice Ho , et al. · 2024

This study demonstrated a link between meteorological factors and the superspreading potential of COVID-19. We speculated that cold weather and rainy days reduced the social activities of individuals minimizing the interaction with others …

Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study Open

Huwen Wang, Yuchen Wei, Chi Tim Hung, Guozhang Lin, Xiaoting Jiang , et al. · 2024

Projection of dengue fever transmissibility under climate change in South and Southeast Asian countries Open

Yawen Wang, Conglu Li, Shi Zhao, Yuchen Wei, Kehang Li , et al. · 2024

Vector-borne infectious disease such as dengue fever (DF) has spread rapidly due to more suitable living environments. Considering the limited studies investigating the disease spread under climate change in South and Southeast Asia, this …

LncRNA EILA promotes CDK4/6 inhibitor resistance in breast cancer by stabilizing cyclin E1 protein Open

Zijie Cai, Qianfeng Shi, Yudong Li, Liang Jin, Shunying Li , et al. · 2023

CDK4/6 inhibitors (CDK4/6i) plus endocrine therapy are now standard first-line therapy for advanced HR + /HER2 − breast cancer, but developing resistance is just a matter of time in these patients. Here, we report that a cyclin E1–interact…

Projection of Dengue Fever Infection Under Climate Change: A Modelling Study Open

Yawen Wang, Conglu Li, Xiaoting Jiang, Shi Yin, Chao Ren , et al. · 2023

mRNA vaccination in breast cancer: current progress and future direction Open

Xiaoting Jiang, Qiang Liu · 2023

Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: a retrospective cohort study using real-world data Open

Huwen Wang, Yuchen Wei, Chi Tim Hung, Xiaoting Jiang, Conglu Li , et al. · 2023

This research was supported by Health and Medical Research Fund [grant numbers COVID190105, COVID19F03, INF-CUHK-1], Collaborative Research Fund of University Grants Committee [grant numbers C4139-20G], National Natural Science Foundation …

Impact of extreme weather on dengue fever infection in four Asian countries: A modelling analysis Open

Yawen Wang, Yuchen Wei, Kehang Li, Xiaoting Jiang, Conglu Li , et al. · 2022

The rapid spread of dengue fever (DF) infection has posed severe threats to global health. Environmental factors, such as weather conditions, are believed to regulate DF spread. While previous research reported inconsistent change of DF ri…

mPR-Specific Actions Influence Maintenance of the Blood–Brain Barrier (BBB) Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Akhil Padarti, Dinesh G. Goswami, Mark Smith , et al. · 2022

Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial microvascular sinusoids that result in increased susceptibility to hemorrhagic stroke. It has been demonstrated that three CCM proteins (CCM1, CCM…

CCM signaling complex (CSC) couples both classic and non-classic Progesterone receptor signaling Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti, Cameron C. Ellis , et al. · 2022

Retraction Note: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho Open

Xujun He, Ying‐Yu Ma, Sheng Yu, Xiaoting Jiang, Yi-Ding Lu , et al. · 2022

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/1471-2407-14-218.

CCM signaling complex (CSC) couples both classic and non-classic progesterone receptor signaling Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti, Cameron C. Ellis , et al. · 2022

Background Breast cancer, the most commonly diagnosed cancer, remains the second leading cause of cancer death in the United States, and excessive Progesterone (PRG) or Mifepristone (MIF) exposure, including females under Hormone Replaceme…

CCM signaling complex (CSC) couples both classic and non-classic progesterone receptor signaling Open

Jun Zhang, Johnathan Abou‐Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti , et al. · 2022

Background : Breast cancer, the most commonly diagnosed cancer, remains the second leading cause of cancer death in the United States, and excessive Progesterone (PRG) or Mifepristone (MIF) exposure, including females under Hormone Replace…

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women Open

Johnathan Abou‐Fadel, Brian Grajeda, Xiaoting Jiang, Alyssa-Marie D. Cailing-De La O, Esmeralda Flores , et al. · 2021

Breast cancer is the most commonly diagnosed cancer worldwide and remains the second leading cause of cancer death. While breast cancer mortality has steadily declined over the past decades through medical advances, an alarming disparity i…

Transcriptome-wide and expression analysis of the NAC gene family in pepino ( <i>Solanum muricatum</i> ) during drought stress Open

Shipeng Yang, Haodong Zhu, Liping Huang, Guangnan Zhang, Lihui Wang , et al. · 2021

Solanum muricatum (Pepino) is an increasingly popular solanaceous crop and is tolerant of drought conditions. In this study, 71 NAC transcription factor family genes of S. muricatum were selected to provide a theoretical basis for subseque…

Peer Review #1 of "Transcriptome-wide and expression analysis of the NAC gene family in pepino (Solanum muricatum) during drought stress (v0.2)" Open

Shipeng Yang, Haodong Zhu, Liping Huang, Guangnan Zhang, Lihui Wang , et al. · 2021

Solanum muricatum (Pepino) is an increasingly popular solanaceous crop and is tolerant of drought conditions.In this study, 71 NAC transcription factor family genes of Solanum muricatum were selected to provide a theoretical basis for subs…

Peer Review #1 of "Transcriptome-wide and expression analysis of the NAC gene family in pepino (Solanum muricatum) during drought stress (v0.1)" Open

Shipeng Yang, Haodong Zhu, Liping Huang, Guangnan Zhang, Lihui Wang , et al. · 2021

Solanum muricatum (Pepino) is an increasingly popular solanaceous crop and is tolerant of drought conditions.In this study, 71 NAC transcription factor family genes of Solanum muricatum were selected to provide a theoretical basis for subs…

Peer Review #2 of "Transcriptome-wide and expression analysis of the NAC gene family in pepino (Solanum muricatum) during drought stress (v0.1)" Open

Shipeng Yang, Haodong Zhu, Liping Huang, Guangnan Zhang, Lihui Wang , et al. · 2021

Solanum muricatum (Pepino) is an increasingly popular solanaceous crop and is tolerant of drought conditions.In this study, 71 NAC transcription factor family genes of Solanum muricatum were selected to provide a theoretical basis for subs…

CCM Signaling Complex (CSC) Couples Both Classic and Non-Classic Progesterone Receptor Signaling Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti, Cameron C. Ellis , et al. · 2021

CCM signaling complex (CSC) is a master regulator governing homeostasis of progestins and their mediated signaling cascades Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Akhil Padarti, Dinesh G. Goswami, Mark Smith , et al. · 2020

We demonstrate that a novel signaling network among the CSC and mPRS is dynamically modulated and fine-tuned with intricate feedback regulations in PR negative cells, especially endothelial cells (ECs). Depletion of any of three CCMs (1, 2…

CCM signaling complex (CSC) coupling both classic and non-classic progesterone receptor signaling Open

Johnathan Abou‐Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti, Cameron C. Ellis , et al. · 2020

Excessive progesterone (PRG) may increase breast cancer risk under hormone therapy during postmenopause or hormonal contraception. As a sex steroid hormone, PRG exerts its cellular responses through signaling cascades involving classic (ge…

Redefining PTB domain into independently functional dual cores Open

Jun Zhang, Akhil Padarti, Xiaoting Jiang, Johnathan Abou‐Fadel · 2020

Current understanding of phosphotyrosine binding (PTB) domain is limited. Recently, we revealed a novel atypical phosphotyrosine binding (aPTB) domain in CCM2, making it a dual PTB domain-containing protein. Since aPTB domain is only 1/3 o…

ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy Open

Annapoorna Kannan, Xiaoting Jiang, Lan He, Saif Ahmad, Laxman Gangwani · 2019

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by homozygous mutation or deletion of the survival motor neuron 1 (SMN1) gene. A second copy, SMN2, is similar to SMN1 but produces ∼10% SMN protein because of a single-point…

Xiaoting Jiang YOU? Author Swipe