Xiaoting Tian
YOU?
Author Swipe
View article: ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid
ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid Open
View article: An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons
An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons Open
N -methyl- d -aspartate receptors (NMDARs), key excitatory ion channels, have gained attention as anti-depression targets. NMDARs consist of two GluN1 and two GluN2 subunits (2A-2D), which determine their pharmacological properties. Few co…
View article: Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension
Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension Open
BACKGROUND Pulmonary arterial hypertension (PAH) is an incurable disease initiated by endothelial dysfunction, secondary to vascular inflammation and occlusive pulmonary arterial vascular remodeling, resulting in elevated pulmonary arteria…
View article: The Effectiveness of Curcumin, Resveratrol, and Silymarin on <scp>MASLD</scp>: A Systematic Review and Meta‐Analysis
The Effectiveness of Curcumin, Resveratrol, and Silymarin on <span>MASLD</span>: A Systematic Review and Meta‐Analysis Open
Polyphenols, known for their potent antioxidant and anti‐inflammatory properties, have emerged as promising, natural, and safe complementary treatment options for metabolic‐associated steatotic liver disease (MASLD). Among these, curcumin,…
View article: Downregulation of the m6A reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members
Downregulation of the m6A reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members Open
N6-Methyladenosine (m6A) is the most prevalent mRNA modification. Its biological function primarily relies on its "Reader" protein, such as YTHDC2. Previous studies have shown that YTHDC2 downregulation is a procarcin…
View article: Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives
Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives Open
The concise and highly convergent synthesis of the isodityrosine unit of seongsanamide A–D and its derivatives bearing a diaryl ether moiety is described. In this work, the synthetic strategy features palladium-catalyzed C(sp3)–H functiona…
View article: Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression
Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression Open
View article: Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes
Ratiometric electrochemical OR gate assay for NSCLC-derived exosomes Open
View article: Additional file 4 of Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression
Additional file 4 of Network pharmacological analysis of corosolic acid reveals P4HA2 inhibits hepatocellular carcinoma progression Open
Supplementary Material 4
View article: A positive feedback circuit between RN7SK snRNA and m6A readers is essential for tumorigenesis
A positive feedback circuit between RN7SK snRNA and m6A readers is essential for tumorigenesis Open
View article: Network pharmacological analysis of corosolic acid inhibits hepatocellular carcinoma progression through P4HA2
Network pharmacological analysis of corosolic acid inhibits hepatocellular carcinoma progression through P4HA2 Open
Hepatocellular carcinoma (HCC) is a common cancer with very limited therapeutic options. Our previous study revealed that corosolic acid inhibited HCC proliferation and enhanced chemotherapy sensitivity. This study set out to identify the …
View article: IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells
IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells Open
View article: A novel antidepressant acting<i>via</i>allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons
A novel antidepressant acting<i>via</i>allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons Open
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated calcium-permeable excitatory channels. They have attracted great interest as potential targets for the treatment of depression in recent years. NMDARs typically assemble as hetero…
View article: YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma
YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma Open
YAP is a transcriptional co-activator with critical roles in tumorigenesis. However, its upstream regulatory mechanism, especially how its mRNA stability is regulated, remains to be further studied. Here, we validated that YAP expression w…
View article: <scp>ISGylation</scp> of <scp>EMD</scp> promotes its interaction with <scp>PDHA</scp> to inhibit aerobic oxidation in lung adenocarcinoma
<span>ISGylation</span> of <span>EMD</span> promotes its interaction with <span>PDHA</span> to inhibit aerobic oxidation in lung adenocarcinoma Open
Abnormal nuclear structure caused by dysregulation of skeletal proteins is a common phenomenon in tumour cells. However, how skeletal proteins promote tumorigenesis remains uncovered. Here, we revealed the mechanism by which skeletal prote…
View article: A Versatile Electrochemical Biosensor for the Detection of Circulating MicroRNA toward Non‐Small Cell Lung Cancer Diagnosis (Small 22/2022)
A Versatile Electrochemical Biosensor for the Detection of Circulating MicroRNA toward Non‐Small Cell Lung Cancer Diagnosis (Small 22/2022) Open
Cancer Diagnostics In article number 2200784, Kun Qian, Jiayi Wang, and co-workers develop a versatile electrochemical biosensing system for circulating miRNA detection by DNAzyme cleavage cycling amplification and hybridization chain reac…
View article: Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin
Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin Open
Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitat…
View article: Cover Image, Volume 42, Issue 4
Cover Image, Volume 42, Issue 4 Open
The cover image is based on the Original Article Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma by Jiayi Wang et al., https://doi.org/10.1002/cac2.12275. [Image: see text]
View article: Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma
Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma Open
Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma (LUAD). Intracellular antioxidant systems are required for pro…
View article: YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription
YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription Open
Yes-associated protein (YAP) activation is crucial for tumor formation and development, and its stability is regulated by ubiquitination. ISGylation is a type of ubiquitination like post-translational modification, whereas whether YAP is I…
View article: The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma
The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma Open
Background Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer. Patient prognosis is poor, and the existing therapeutic strategies for LUAD are far from satisfactory. Recently, targeting N6-methyladenosine (m 6 A) modifica…
View article: Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma
Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma Open
Ferroptosis is an iron- and lipid peroxidation-dependent form of regulated cell death. The release of labile iron is one of the important factors affecting sensitivity to ferroptosis. Yes-associated protein (YAP) controls intracellular iro…
View article: Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway
Novel Pyrazolo[3,4-b] Pyridine Derivative (HLQ2g) Attenuates Hypoxic Pulmonary Hypertension via Restoring cGKI Expression and BMP Signaling Pathway Open
Pulmonary hypertension (PH) is an extremely serious cardiopulmonary disease, finally leading to progressive right ventricular failure and death. Our previous studies have nominated HLQ2g, a pyrazolo[3,4-b] pyridine derivative stimulating s…
View article: The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway
The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway Open
Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of hepatocellular carcinoma and liver failure. Fuzheng Huayu formula (FZHY) is a traditional Chinese medicine formula treated liver fibrosis in China approved …
View article: The Essential Roles of Exosome and CircRNA_101093 to Desensitize Lung Adenocarcinoma to Ferroptosis
The Essential Roles of Exosome and CircRNA_101093 to Desensitize Lung Adenocarcinoma to Ferroptosis Open
Background Resistance to ferroptosis, a regulated cell death caused by iron-dependent excessive accumulation of lipid peroxides has recently been linked to lung adenocarcinoma (LUAD), the most prevalent lung cancer subtype. Despite intrace…
View article: CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma
CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma Open
Ferroptosis is a new form of regulated cell death and closely related to cancer. However, the mechanism underlying the regulation of ferroptosis in lung adenocarcinoma (LUAD) remains unclear. IB, IHC and ELISA were performed to analyze pro…
View article: Targeting SLC3A2 Subunit of System XC- is Essential for m6A Reader YTHDC2 to be an Endogenous Ferroptosis Inducer in Lung Adenocarcinoma
Targeting SLC3A2 Subunit of System XC- is Essential for m6A Reader YTHDC2 to be an Endogenous Ferroptosis Inducer in Lung Adenocarcinoma Open
Background: The m 6 A reader YT521-B homology containing 2 (YTHDC2) inhibits lung adenocarcinoma (LUAD) tumorigenesis by suppressing solute carrier 7A11 (SLC7A11)-dependent antioxidant function. SLC7A11 is a major functional subunit of sys…
View article: Efficient Oxidative Coupling of Isochroman with Primary Arylamines Catalyzed by Heterogeneous Ni-Containing Layered Double Oxide
Efficient Oxidative Coupling of Isochroman with Primary Arylamines Catalyzed by Heterogeneous Ni-Containing Layered Double Oxide Open
An efficient heterogeneous catalytic system based on NiGa layered double oxide (Ni3Ga-LDO) for the C-N coupling between isochroman and primary arylamines has been described.Various primary arylamines were tolerated by the catalytic system,…
View article: Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma
Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma Open
Rationale: Ferroptosis, a newly identified form of regulated cell death, can be induced following the inhibition of cystine-glutamate antiporter system XC- because of the impaired uptake of cystine. However, th…
View article: A novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis Through Inhibiting Notch Signaling Pathway
A novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis Through Inhibiting Notch Signaling Pathway Open
Background: Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of liver failure and hepatocellular carcinoma. It is necessary to develop an effective antifibrotic strategy. It has been reported that Fuzheng Hua…