Xiaowei Du
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View article: Chromosome‐scale genome of <i>Dioscorea nipponica</i> and functional diversification of the DnUGT73 subfamily in steroidal saponin glycosylation
Chromosome‐scale genome of <i>Dioscorea nipponica</i> and functional diversification of the DnUGT73 subfamily in steroidal saponin glycosylation Open
The UGT73 subfamily in Dioscorea nipponica exhibits remarkable catalytic diversity in glycosylation of steroidal saponins. Notably, DnU26 from the UGT73 subfamily and members of the phylogenetically distant UGT91 family independently evolv…
View article: BTVT ameliorates offspring blood<b>-</b>brain barrier damage induced by prenatal and lactational neodymium oxide exposure via the gut<b>-</b>brain axis.
BTVT ameliorates offspring blood<b>-</b>brain barrier damage induced by prenatal and lactational neodymium oxide exposure via the gut<b>-</b>brain axis. Open
Maternal exposure to Nd2O3 during pregnancy and lactation disrupts intestinal health and BBB integrity in offspring, elevates brain neodymium accumulation, and induces neuronal degeneration. BTVT effectively mitigates Nd2O3-induced intesti…
View article: MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and PI3K-Akt-ROS pathway.
MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and PI3K-Akt-ROS pathway. Open
Background Alzheimer's disease (AD) stands as one of the prevalent irreversible neurodegenerative conditions marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)-Hippo pathway is pivotal in re…
View article: Multiple mineralization events at Paleozoic Sanchakou porphyry Cu deposit, Xinjiang: New insights from geology, geochronology, fluid inclusions, and H-O-C isotopes
Multiple mineralization events at Paleozoic Sanchakou porphyry Cu deposit, Xinjiang: New insights from geology, geochronology, fluid inclusions, and H-O-C isotopes Open
The Sanchakou Cu deposit is located in the eastern section of the Dananhu arc belt in Eastern Tianshan, Xinjiang, and recorded multiple magmatic-mineralization events. The porphyry-style mineralization period produced disseminated, sulfide…
View article: Studies on biotransformation mechanism of Fusarium sp. C39 to enhance saponin content of Paridis Rhizoma
Studies on biotransformation mechanism of Fusarium sp. C39 to enhance saponin content of Paridis Rhizoma Open
Paridis Rhizoma is a natural medicine with strong anti-tumor and anti-inflammatory activities. Our previous research have found that Fusarium sp. C39, an endophytic fungus isolated from Dioscorea nipponica which contains the similar chemic…
View article: Study of Saponin Components after Biotransformation of <i>Dioscorea nipponica</i> by Endophytic Fungi C39
Study of Saponin Components after Biotransformation of <i>Dioscorea nipponica</i> by Endophytic Fungi C39 Open
This study conducted the solid fermentation process of Dioscorea nipponica using endophytic fungi C39 to determine the changes in the diosgenin concentration. The results revealed that endophytic fungi C39 could effectively biotransform th…
View article: Comparing Microporous and Native Corn Starch as Binders on the Textural Properties of African Locust Bean Bouillon Cubes
Comparing Microporous and Native Corn Starch as Binders on the Textural Properties of African Locust Bean Bouillon Cubes Open
Seeds from the African locust bean (ALB; Parkia biglobosa) are commonly used in West African diets. This study investigated the effect of microporous and native corn starches as binders on textural properties of ALB bouillon cubes, using g…
View article: Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects
Zisheng Shenqi decoction ameliorates monosodium urate crystal-induced gouty arthritis in rats through anti-inflammatory and anti-oxidative effects Open
Based on traditional Chinese medicinal theories on gouty arthritis, Zisheng Shenqi decoction (ZSD), a novel Chinese medicinal formula, was developed due to its multiple functions, including reinforcing renal function, promoting blood circu…