Xiaowei Ma
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View article: Rethinking altitude and child growth: evidence from a multi-altitude study in Tibet
Rethinking altitude and child growth: evidence from a multi-altitude study in Tibet Open
Objective High-altitude environments have long been linked to growth deficits in children, often attributed to chronic hypoxia. Yet, emerging evidence from better-resourced highland communities suggests that socioeconomic and infrastructur…
View article: The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination Open
View article: Prognostic Value of a Nomogram Model Based on Tumor Immune Markers and Clinical Factors for Adult Primary Gliomas
Prognostic Value of a Nomogram Model Based on Tumor Immune Markers and Clinical Factors for Adult Primary Gliomas Open
Objective: This study aimed to analyze the factors associated with overall survival (OS) in adult patients with primary gliomas, develop a nomogram prediction model, and optimize its predictive performance. Methods: Clinical data were retr…
View article: Quantitative and Multiplexing Analysis of MicroRNAs by Direct Full-Length Sequencing in Nanopores
Quantitative and Multiplexing Analysis of MicroRNAs by Direct Full-Length Sequencing in Nanopores Open
MicroRNAs (miRNAs) play important regulatory roles in biology. Direct sequencing of miRNAs in full-length can reveal comprehensive information on their sequences, abundance, and modifications, which, however, has yet to be achieved due to …
View article: Gamma oscillatory transcranial direct current stimulation of motor cortex enhances corticospinal excitability and brain connectivity in healthy individuals
Gamma oscillatory transcranial direct current stimulation of motor cortex enhances corticospinal excitability and brain connectivity in healthy individuals Open
Cortical excitability, the tendency of neurons to respond to various stimuli, is impaired in most neuropsychiatric conditions. Non-invasive brain stimulation can exert therapeutic effects by modulating the cortical excitability. Transcrani…
View article: Flavin‐Containing Monooxygenase 3 Genetic Variants and Possible Susceptibility to Coronary Heart Disease Among Han Chinese With Type 2 Diabetes
Flavin‐Containing Monooxygenase 3 Genetic Variants and Possible Susceptibility to Coronary Heart Disease Among Han Chinese With Type 2 Diabetes Open
Purpose: To explore the flavin‐containing monooxygenase 3 (FMO3) single‐nucleotide polymorphisms (SNPs) and their connection to coronary heart disease (CHD) among Han Chinese with type 2 diabetes (T2D). Methods: The case‐control research i…
View article: The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination Open
Background: Although the treatment of lung cancer has been well developed, the survival rate for lung squamous cell carcinoma (LUSC) is still low. It is meaningful to explore new molecular targets and develop new treatment strategies. SH3R…
View article: Plasma Lipidomic Profiles Improve upon Traditional Risk Factors for the Prediction of Arterial Stiffness Among Patients with Type 2 Diabetes Mellitum: A Randomized, Placebo-Controlled Trial
Plasma Lipidomic Profiles Improve upon Traditional Risk Factors for the Prediction of Arterial Stiffness Among Patients with Type 2 Diabetes Mellitum: A Randomized, Placebo-Controlled Trial Open
Background: Exercise or vitamin D intervention can reduce the risk of arterial stiffness; however, the underlying mechanisms of lipid metabolism remain unexplored. To examine the effects of a 12-week moderate and vigorous exercise program …
View article: Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases (Adv. Sci. 32/2024)
Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases (Adv. Sci. 32/2024) Open
Innovative Nanotechnology in Drug Delivery Systems Posterior segment ocular disorders are common clinical diseases, which can lead to irreversible blindness. In article number 2403399, Mei Yang, Wei Tao, Xingtao Zhou, Jinhai Huang, and the…
View article: Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis
Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis Open
Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathoge…
View article: Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases
Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases Open
Funduscopic diseases, including diabetic retinopathy (DR) and age‐related macular degeneration (AMD), significantly impact global visual health, leading to impaired vision and irreversible blindness. Delivering drugs to the posterior segme…
View article: Clinical Features of Severe Ovarian Hyperstimulation Syndrome with Hydrothorax
Clinical Features of Severe Ovarian Hyperstimulation Syndrome with Hydrothorax Open
Problem: Does the presence of hydrothorax suggest that severe ovarian hyperstimulation syndrome (OHSS) is associated with more severe conditions and worse pregnancy outcomes? Method of study: The clinical data for 868 hospital patients wit…
View article: The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity Open
View article: Clinical features of severe ovarian hyperstimulation syndrome with hydrothorax
Clinical features of severe ovarian hyperstimulation syndrome with hydrothorax Open
Research question: Does the presence of hydrothorax suggest that severe ovarian hyperstimulation syndrome (OHSS) is associated with more severe conditions and worse pregnancy outcomes? Design: The clinical data for 868 hospital patients wi…
View article: Targeting iron metabolism in osteosarcoma
Targeting iron metabolism in osteosarcoma Open
Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent abili…
View article: Innovation in proximal femoral replacement for oncology patients—A novel eggshell procedure
Innovation in proximal femoral replacement for oncology patients—A novel eggshell procedure Open
Our eggshell procedure is convenient and accessible. On the one hand, it can reduce surgical side injuries without adding additional complications, and on the other it allows to improve joint mobility and life quality while diminishing the…
View article: The impact of pharmacist practice of medication therapy management in ambulatory care: an experience from a comprehensive Chinese hospital
The impact of pharmacist practice of medication therapy management in ambulatory care: an experience from a comprehensive Chinese hospital Open
Backgroud With the reform of medical system in China, Beijing municipal hospitals explored a new pharmaceutical care model and set up medication therapy management services (MTMs) in ambulatory care since 2019. We were one of the first hos…
View article: Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis
Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis Open
Sarcopenia is a syndrome characterized by progressive loss of skeletal muscle mass, strength and function, which is one of the most important clinical features of cancer malnutrition, representing a poor prognostic indicator in oncology. S…
View article: Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumors
Percutaneous pedicle screw fixation combined with percutaneous vertebroplasty for the treatment of thoracic and lumbar metastatic tumors Open
Patients with spinal metastases have a great risk of spinal instability and even spinal cord compression while enduring pain. Therefore, timely and appropriate surgical treatment is an effective means to stabilize the spine and avoid spina…
View article: Clinical characteristics of the host DNA-removed metagenomic next-generation sequencing technology for detecting SARS-CoV-2, revealing host local immune signaling and assisting genomic epidemiology
Clinical characteristics of the host DNA-removed metagenomic next-generation sequencing technology for detecting SARS-CoV-2, revealing host local immune signaling and assisting genomic epidemiology Open
Background Metagenomic next-generation sequencing (mNGS) technology has been central in detecting infectious diseases and helping to simultaneously reveal the complex interplay between invaders and their hosts immune response characteristi…
View article: Bone-Targeted Dual Functional Lipid-coated Drug Delivery System for Osteosarcoma Therapy
Bone-Targeted Dual Functional Lipid-coated Drug Delivery System for Osteosarcoma Therapy Open
View article: Alpha emitter radium-223 in patients with metastatic castration-resistant prostate cancer: A cost-utility analysis
Alpha emitter radium-223 in patients with metastatic castration-resistant prostate cancer: A cost-utility analysis Open
Objective: To assess the cost effectiveness of radium-223 dichloride for patients with metastatic castration-resistant prostate cancer (mCRPC) in China. Materials and methods: A Markov model was developed to estimate the long-term health a…
View article: Anthropometric indices, body function, and physical fitness reference values for Tibetan ethnic children aged 6–17 residing at 3,650 meters above sea level
Anthropometric indices, body function, and physical fitness reference values for Tibetan ethnic children aged 6–17 residing at 3,650 meters above sea level Open
Objectives It is known that high altitude influences the growth metrics of high-altitude residents. Using a WHO-recommended standard, the research aimed to establish growth and development reference values for children of Tibetan ethnicity…
View article: Recent advances in PCR-free nucleic acid detection for SARS-COV-2
Recent advances in PCR-free nucleic acid detection for SARS-COV-2 Open
As the outbreak of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory disease coronavirus 2 (SARS-COV-2), fast, accurate, and economic detection of viral infection has become crucial for stopping the spread. Polymerase …
View article: Comprehensive Analysis and Reinforcement Learning of Hypoxic Genes Based on Four Machine Learning Algorithms for Estimating the Immune Landscape, Clinical Outcomes, and Therapeutic Implications in Patients With Lung Adenocarcinoma
Comprehensive Analysis and Reinforcement Learning of Hypoxic Genes Based on Four Machine Learning Algorithms for Estimating the Immune Landscape, Clinical Outcomes, and Therapeutic Implications in Patients With Lung Adenocarcinoma Open
Background Patients with lung adenocarcinoma (LUAD) exhibit significant heterogeneity in therapeutic responses and overall survival (OS). In recent years, accumulating research has uncovered the critical roles of hypoxia in a variety of so…
View article: Outstanding prognostic value of novel ferroptosis-related genes in chemoresistance osteosarcoma patients
Outstanding prognostic value of novel ferroptosis-related genes in chemoresistance osteosarcoma patients Open
Osteosarcoma (OS) is the most common bone-derived tumor, and chemoresistance is a pivotal factor in the poor prognosis of patients with OS. Ferroptosis, as an emerging modality of regulated cell death, has demonstrated potential value in t…
View article: Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles
Integration-free induced pluripotent stem cell line derived from a 62-years-old male donor with APOE-epsilon4/epsilon4 alleles Open
View article: Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis
Mechanisms and Molecular Targets of BuShenHuoXue Formula for Osteoarthritis Open
The aim was to identify latent mechanism of BuShenHuoXue (BSHX) formula for the management of osteoarthritis (OA) through the network pharmacology approach and experimental validation. We obtained OA-related targets through the Gene Expres…
View article: Risk assessment for SARS-CoV-2 Delta Variant B.1.617.2 transmission in public places: a retrospective study (Preprint)
Risk assessment for SARS-CoV-2 Delta Variant B.1.617.2 transmission in public places: a retrospective study (Preprint) Open
BACKGROUND Public places that COVID-19 patients visited are the trigger of secondary transmission. The severity of symptoms, expectoration symptoms, adolescents ,and high virus load are the risk factors for transmission. Transmission is a…
View article: Immunological and prognostic significance of novel ferroptosis-related genes in soft tissue sarcoma
Immunological and prognostic significance of novel ferroptosis-related genes in soft tissue sarcoma Open
Background Ferroptosis has exhibited great potential in the treatment of cancer and has gained widespread attention in soft tissue sarcoma (STS). The aim was to explore the immunological and prognostic significance of novel ferroptosis-rel…