Chen Mao
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View article: PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence
PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence Open
Objective This study aims to explore the contribution of PIM1 kinase-mediated cellular senescence to the pathogenesis of stress urinary incontinence (SUI) and to assess the therapeutic potential of inhibiting PIM1. Methods A mouse model of…
View article: Bioinformatics Exploration of the Differential Gene Expression Profiles and Signal Pathways in the Treatment of Acne by Photodynamic Therapy
Bioinformatics Exploration of the Differential Gene Expression Profiles and Signal Pathways in the Treatment of Acne by Photodynamic Therapy Open
View article: Green, Sustainable, and Circular Forest Products
Green, Sustainable, and Circular Forest Products Open
In this book chapter, we first provided a concise overview of global forest products and their impacts and benefits. Then, we introduced the theory of green, sustainable, and circular forest products to our readers. Through a literature re…
View article: Nanotechnology for the treatment of atherosclerosis: Strategies, practical applications and future perspectives
Nanotechnology for the treatment of atherosclerosis: Strategies, practical applications and future perspectives Open
View article: Clinicohistopathological features and outcome of cutaneous and systemic plasmacytosis in 21 Chinese cases: A retrospective study
Clinicohistopathological features and outcome of cutaneous and systemic plasmacytosis in 21 Chinese cases: A retrospective study Open
Background Cutaneous and systemic plasmacytosis is a rare disorder predominantly observed in individuals of Asian descent. The aetiology, treatment modalities, and prognosis of this condition remain unclear. Objective To describe the clini…
View article: Inbreeding depression and functional analysis of major genes in the F1-selfed progeny of the apple ‘Megumi’
Inbreeding depression and functional analysis of major genes in the F1-selfed progeny of the apple ‘Megumi’ Open
View article: Juvenile xanthogranuloma as a potential early manifestation of neurofibromatosis type 1: A case report
Juvenile xanthogranuloma as a potential early manifestation of neurofibromatosis type 1: A case report Open
Rationale: Juvenile xanthogranuloma (JXG), the most common form of non-Langerhans cell histiocytosis, typically presents in early childhood and often resolves spontaneously. Due to its generally favorable prognosis, physical examination ma…
View article: Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study Open
View article: Classification of autoimmune diseases from Peripheral blood TCR repertoires by multimodal multi-instance learning
Classification of autoimmune diseases from Peripheral blood TCR repertoires by multimodal multi-instance learning Open
T cell receptor (TCR) repertoires encode critical immunological signatures for autoimmune diseases, yet their clinical application remains limited by sequence sparsity and low witness rates. We developed EAMil, a multi-instance deep learni…
View article: Microwave-assisted synthesis of high-performance TaC nanorods for enhanced electromagnetic wave absorption
Microwave-assisted synthesis of high-performance TaC nanorods for enhanced electromagnetic wave absorption Open
One-dimensional tantalum carbide (TaC) nanorods are considered promising candidates for high-temperature electromagnetic wave (EMW) absorption because of their intrinsically high electrical conductivity and exceptional thermal stability. H…
View article: 419P Real-world treatment pattern and biomarker testing landscape of advanced gastric/gastroesophageal junction cancer (GC/GEJC) in China (SURPASS study)
419P Real-world treatment pattern and biomarker testing landscape of advanced gastric/gastroesophageal junction cancer (GC/GEJC) in China (SURPASS study) Open
View article: The effects of frailty, mental health, and cardiac function on quality of life in patients undergoing transcatheter aortic valve replacement
The effects of frailty, mental health, and cardiac function on quality of life in patients undergoing transcatheter aortic valve replacement Open
View article: The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study
The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study Open
Background With social progress, social stress (SS) has become a key factor affecting health. Unhealthy lifestyles may exacerbate these effects. However, the relationship between SS, lifestyle, and older adults’ mortality rate still needs …
View article: How Three Decades of Forestation Has Impacted Forest Fragmentation in Southern China
How Three Decades of Forestation Has Impacted Forest Fragmentation in Southern China Open
Forest cover dynamics are studied on a routine basis, but how changes in forest cover impact forest fragmentation has rarely been studied over a long time period resolution. This is, however, important because forest fragmentation critical…
View article: Association Between Dietary Betaine Intake and Dyslipidemia in Chinese Children and Adolescents: A Cross-Sectional Study
Association Between Dietary Betaine Intake and Dyslipidemia in Chinese Children and Adolescents: A Cross-Sectional Study Open
Background: Evidence remains limited on the effects of dietary betaine intake and dyslipidemia. We aim to investigate the association between dietary betaine intake and dyslipidemia in Chinese children and adolescents and illustrate the di…
View article: LightCTL: lightweight contrastive TCR-pMHC specificity learning with context-aware prompt
LightCTL: lightweight contrastive TCR-pMHC specificity learning with context-aware prompt Open
Identification of T cell receptor (TCR) specificities for antigens from large-scale single-cell or bulk TCR repertoire data plays a vital role in disease diagnosis and immunotherapy. In silico prediction models have emerged in recent years…
View article: The impact of social stress and healthy lifestyle on the mortality of Chinese older adults: a prospective cohort study (Preprint)
The impact of social stress and healthy lifestyle on the mortality of Chinese older adults: a prospective cohort study (Preprint) Open
UNSTRUCTURED Objectives:This study aimed to investigate the effects of social stress (SS) on older Chinese adults and whether lifestyle factors mediate this association. Methods:Three groups of social stress were defined through latent cl…
View article: Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death
Association of Accelerometer‐Derived Physical Activity Pattern With the Risks of All‐Cause, Cardiovascular Disease, and Cancer Death Open
Background Current guidelines suggest engaging in a minimum of 150 minutes of moderate to vigorous physical activity (MVPA) each week to support overall health. However, the effect of concentrated versus evenly distributed physical activit…
View article: Accelerometer-derived physical activity patterns and incident type 2 diabetes: a prospective cohort study
Accelerometer-derived physical activity patterns and incident type 2 diabetes: a prospective cohort study Open
Background Emerging evidence suggests a significant relationship between the duration of physical activity (PA) and the incidence of type 2 diabetes (T2D). However, the association between the “weekend warrior” (WW) pattern—characterized b…
View article: Healthy sleep patterns and risk of hospitalization for infection: a large community-based cohort study
Healthy sleep patterns and risk of hospitalization for infection: a large community-based cohort study Open
View article: Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population
Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population Open
Long-term cSBP, cDBP and cMAP were associated with subsequent CVD and only found in people younger than 60 years of age, whereas cPP was associated with stroke only across all ages. Cumulative BP may provide a better prediction of cardiova…
View article: [Association between weight-adjusted waist index and pain: A cross-sectional study].
[Association between weight-adjusted waist index and pain: A cross-sectional study]. Open
For American adults, there was no significant correlation between WWI and acute pain or subacute pain. However, as WWI increases, so does the prevalence of chronic pain. Further validation of this conclusion through large-scale prospective…
View article: The effects of dry density and moisture content on the shear characteristics of clay-type muddy interlayer
The effects of dry density and moisture content on the shear characteristics of clay-type muddy interlayer Open
View article: ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle
ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle Open
Background Few researches have investigated the molecular mechanism responsible for the age‐related loss of the pelvic floor muscle (PFM) mass and functionality—a pivotal contributor to pelvic organ prolapse and diminished physical well‐be…
View article: Clinical characteristics and immunotherapy response in paraneoplastic neurologic syndrome patients with increased number of high-risk antibodies
Clinical characteristics and immunotherapy response in paraneoplastic neurologic syndrome patients with increased number of high-risk antibodies Open
Objective To investigate the differences of clinical characteristics and treatment outcomes between paraneoplastic neurologic syndrome (PNS) patients with one high-risk antibody and patients with two high-risk antibodies. Methods We retros…
View article: Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-Mesenchymal Transition in Mice and Stroma Cells
Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-Mesenchymal Transition in Mice and Stroma Cells Open
Objectives: The present study examined the effects of doxazosin on testosterone propionate (TP)-induced prostate growth in vivo and in vitro and its impact on the EMT and TGF-β/Smad signaling pathway. Methods: Mice were treated with TP. Do…
View article: Preoperative Neutrophil-to-Albumin Ratio as a Prognostic Indicator in Advanced Gastric Cancer Undergoing Radical Gastrectomy.
Preoperative Neutrophil-to-Albumin Ratio as a Prognostic Indicator in Advanced Gastric Cancer Undergoing Radical Gastrectomy. Open
The preoperative neutrophil-to-albumin ratio is an independent and reliable prognostic biomarker for overall and recurrence-free survival in patients with advanced gastric cancer undergoing radical gastrectomy. Due to its accessibility, si…
View article: Novel Fluorescent Probes with High Signal-to-Noise Ratios for Lipid Droplets-Specific Bioimaging
Novel Fluorescent Probes with High Signal-to-Noise Ratios for Lipid Droplets-Specific Bioimaging Open
View article: Serum pentraxin-3 as a potential biomarker for diagnosis and prognosis in primary liver cancer: An observational study
Serum pentraxin-3 as a potential biomarker for diagnosis and prognosis in primary liver cancer: An observational study Open
This study aimed to examine serum pentraxin 3 levels in patients with primary liver cancer and to assess its potential as a diagnostic and prognostic biomarker. Serum samples were obtained from 180 patients with primary liver cancer and 18…
View article: Analysis and Design of a Personalized Recommendation System Based on a Dynamic User Interest Model
Analysis and Design of a Personalized Recommendation System Based on a Dynamic User Interest Model Open
With the rapid development of the internet and the explosion of information, providing users with accurate personalized recommendations has become an important research topic. This paper designs and analyzes a personalized recommendation s…