Xiaowen Wang
YOU?
Author Swipe
View article: Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation
Trigonelline Improves Metabolism and Cardiac Function of HFpEF Mice Via Gut Microbiome Alterations‐Mediated AMPK Activation Open
Heart failure with preserved ejection fraction (HFpEF) is a prevalent end‐manifestation of cardiovascular diseases currently lacking effective treatment. Using a high‐fat diet and L‐NAME‐induced mouse model, untargeted metabolomic profilin…
View article: Does Local Government Green Attention Promote Green Total Factor Productivity?
Does Local Government Green Attention Promote Green Total Factor Productivity? Open
Improving green total factor productivity (GTFP) is critical for balancing economic benefits and ecological constraints. While most existing studies emphasize the pivotal role of governments in GTFP enhancement, they predominantly treat go…
View article: A hierarchical three-level meta-analysis of the effects of supplemental histidine on lactational performance in dairy cows and the associated influencing factors
A hierarchical three-level meta-analysis of the effects of supplemental histidine on lactational performance in dairy cows and the associated influencing factors Open
View article: Analysis of survival differences in advanced triple-negative breast cancer: a real-world study
Analysis of survival differences in advanced triple-negative breast cancer: a real-world study Open
Background Advanced triple-negative breast cancer (aTNBC) has a poor prognosis, and there is a dearth of relevant real-world research data. This study is aimed at analyzing the survival outcomes and subgroup characteristics of aTNBC in the…
View article: Clinical practice guidelines for rituximab treatment in children with steroid-sensitive nephrotic syndrome
Clinical practice guidelines for rituximab treatment in children with steroid-sensitive nephrotic syndrome Open
Background Steroid-sensitive nephrotic syndrome is a prevalent glomerular disease in children. The 2021 guidelines for glomerular disease management by Kidney Disease: Improving Global Outcomes and the 2023 recommendations for steroid-sens…
View article: The cochlear cell atlas of Gjb2−/− mice exhibits alterations accompanied by autophagy-related metabolic imbalances
The cochlear cell atlas of Gjb2−/− mice exhibits alterations accompanied by autophagy-related metabolic imbalances Open
View article: The Effect of Different Processing Methods on Metabolite Profiles by Comparative Metabolomics in Kernels and Sprouted Seeds of Foxtail Millet
The Effect of Different Processing Methods on Metabolite Profiles by Comparative Metabolomics in Kernels and Sprouted Seeds of Foxtail Millet Open
Foxtail millet attracts much attention for its rich nutrients and health benefits. However, ultra-polishing has greatly reduced its nutrition. Germination can enhance nutrition value. Nevertheless, knowledge of nutrient changes in kernels …
View article: Green spaces, blue spaces and human health: an updated umbrella review of epidemiological meta-analyses
Green spaces, blue spaces and human health: an updated umbrella review of epidemiological meta-analyses Open
Introduction Green spaces have been recognized for their ecological services, including air purification and biodiversity protection, which contribute to the enhancement of life quality and well-being. However, despite the surge in researc…
View article: A Study of the Social Psychology and Spatial Construction of Workplace Observation Reality Shows Take A Heartwarming Offer as an Example
A Study of the Social Psychology and Spatial Construction of Workplace Observation Reality Shows Take A Heartwarming Offer as an Example Open
In the current era of involution, the employment situation is complex and severe; the workplace reality shows have a large audience space. In recent years, the emergence of workplace observation reality shows, which address the pain points…
View article: An updated meta-analysis of influences of animal, dietary, and operational factors on the effects of supplemental methionine on lactational performances in dairy cows
An updated meta-analysis of influences of animal, dietary, and operational factors on the effects of supplemental methionine on lactational performances in dairy cows Open
Previous studies regarding the effects of supplemental Met on lactational performance in dairy cows are inconsistent, and the potential interfering factors need to be systematically investigated. The standardized mean difference (SMD) of c…
View article: VCL/ICAM-1 pathway is associated with lung inflammatory damage in SARS-CoV-2 Omicron infection
VCL/ICAM-1 pathway is associated with lung inflammatory damage in SARS-CoV-2 Omicron infection Open
SARS-CoV-2 variants present diverse clinical manifestations, necessitating deeper insights into their pathogenic effects. This study employs multi-omics approaches to investigate the molecular mechanisms underlying SARS-CoV-2 infection, fo…
View article: Global, regional and national burden of Parkinson’s disease in people over 55 years of age: a systematic analysis of the global burden of disease study, 1991–2021
Global, regional and national burden of Parkinson’s disease in people over 55 years of age: a systematic analysis of the global burden of disease study, 1991–2021 Open
This study indicates that the burden of PD in individuals aged 55 and above has significantly increased over the past three decades. This trend reflects the profound impact of global aging and socioeconomic development levels on the burden…
View article: Shared diagnostic biomarkers and underlying mechanisms between endometriosis and recurrent implantation failure
Shared diagnostic biomarkers and underlying mechanisms between endometriosis and recurrent implantation failure Open
Background Endometriosis (EMs) is a common condition that causes dysmenorrhea, chronic pelvic pain, and infertility, affecting millions of women worldwide. Despite the use of assisted reproductive technology, EMs patients often experience …
View article: Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis
Integrative analysis of genes provides insights into the molecular and immune characteristics of mitochondria-related genes in atherosclerosis Open
Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation in arterial walls. The role of the interplay between mitochondrial dysfunction and immune inflammation in atherosclerosis is still unclear. This study ai…
View article: Effect of low-frequency ultrasound pretreatment on taste substances in chicken liver by fermentation
Effect of low-frequency ultrasound pretreatment on taste substances in chicken liver by fermentation Open
View article: Food-Grade Pickering Emulsions Stabilized by Ultrasound-Treated Foxtail Millet Prolamin: Characterization and In Vitro Release Behavior of Curcumin
Food-Grade Pickering Emulsions Stabilized by Ultrasound-Treated Foxtail Millet Prolamin: Characterization and In Vitro Release Behavior of Curcumin Open
To date, extensive studies have focused on developing proteins as stabilizers to fabricate food-grade emulsions for encapsulating bioactive compounds aimed at targeted delivery. This paper aimed to develop a novel stabilizer using foxtail …
View article: Ultra-Processed Foods and the Impact on Cardiometabolic Health: The Role of Diet Quality
Ultra-Processed Foods and the Impact on Cardiometabolic Health: The Role of Diet Quality Open
The consumption of ultra-processed foods (UPFs) has surged globally, raising significant public health concerns due to their associations with a range of adverse health outcomes. This review aims to elucidate potential health impacts of UP…
View article: Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction Open
Importance Sex is associated with the clinical presentation, outcomes, and response to treatment in patients with heart failure (HF). However, little is known about the safety and efficacy of treatment with finerenone according to sex. Obj…
View article: CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein Open
The CACHE challenges are a series of prospective benchmarking exercises to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE challenge in which 23 computational teams each select…
View article: phytoremediation of water with different eutrophic characteristics by macrophytes in two life forms
phytoremediation of water with different eutrophic characteristics by macrophytes in two life forms Open
View article: Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling
Prediction of Pharmacokinetic Drug–Drug Interactions Involving Anlotinib as a Victim by Using Physiologically Based Pharmacokinetic Modeling Open
Based on the PBPK modeling, there is a low risk of DDI between anlotinib and potent CYP3A/1A2 inhibitors, but caution and enhanced monitoring for adverse reactions are advised. To mitigate the risk of anti-tumor treatment failure, it is re…
View article: Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy Open
View article: Self-Rated Health Status and the Risk of Incident Type 2 Diabetes: A Prospective Cohort Study of Middle-Aged and Older Chinese
Self-Rated Health Status and the Risk of Incident Type 2 Diabetes: A Prospective Cohort Study of Middle-Aged and Older Chinese Open
Objectives Evidence on the relationship between self-rated health status and incident type 2 diabetes (T2DM) in China is scarce. This study aims to examine the prospective association of self-rated health status with the subsequent risk of…
View article: The Role of Plasma Trough Concentration of Voriconazole and Voriconazole N-Oxide in Its Hepatotoxicity in Adult Patients
The Role of Plasma Trough Concentration of Voriconazole and Voriconazole N-Oxide in Its Hepatotoxicity in Adult Patients Open
VCZ C0 and CN were associated with liver function-related adverse events. Measurement of VCZ CN should be considered for VCZ therapeutic drug monitoring.
View article: Causal association between triglycerides and cholesterol-lowering medication with non-rheumatic valve disease: A 2-sample Mendelian randomization study
Causal association between triglycerides and cholesterol-lowering medication with non-rheumatic valve disease: A 2-sample Mendelian randomization study Open
Previous studies have found a possible causal relationship between triglycerides and lipid-lowering drugs and valvular disease. The aim of this study was to explore the potential causal relationship between triglycerides and lipid-lowering…
View article: CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson’s Disease associated protein
CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson’s Disease associated protein Open
The CACHE challenges are a series of prospective benchmarking exercises meant to evaluate progress in the field of computational hit-finding. Here we report the results of the inaugural CACHE #1 challenge in which 23 computational teams ea…
View article: Refractory Giant Perianal Pyoderma Gangrenosum Successfully Treated with Tofacitinib
Refractory Giant Perianal Pyoderma Gangrenosum Successfully Treated with Tofacitinib Open
View article: Greenness, Blue Spaces and Human Health: An Updated Umbrella Review of Epidemiological Meta-analyses
Greenness, Blue Spaces and Human Health: An Updated Umbrella Review of Epidemiological Meta-analyses Open
We systematically summarizes and evaluates the relationship between green and blue spaces and human health through an umbrella review of epidemiological meta- analyses up to the year 2024. Green spaces have been recognized for their ecolog…
View article: Constructing and validating a predictive nomogram for osteoporosis risk among Chinese single-center male population using the systemic immune-inflammation index
Constructing and validating a predictive nomogram for osteoporosis risk among Chinese single-center male population using the systemic immune-inflammation index Open
View article: Diagnostic performance of PIVKA-II in identifying recurrent hepatocellular carcinoma following curative resection: a retrospective cohort study
Diagnostic performance of PIVKA-II in identifying recurrent hepatocellular carcinoma following curative resection: a retrospective cohort study Open