Xiaoxi Zhang
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View article: HNF1α-Q125ter-mediated mitochondrial dysfunction and impaired mitophagy in β-cells
HNF1α-Q125ter-mediated mitochondrial dysfunction and impaired mitophagy in β-cells Open
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes caused by single-gene mutations. MODY3, the most common subtype, results from mutations in the hepatocyte nuclear factor 1-alpha ( HNF1α ) gene. HNF1α is a transcr…
View article: Effects of litter layer alterations caused by increasing stand age on the seed germination and seedling establishment of Robinia pseudoacacia plantations
Effects of litter layer alterations caused by increasing stand age on the seed germination and seedling establishment of Robinia pseudoacacia plantations Open
View article: Optimization of Polysaccharide Extraction from <i>Astragalus</i> and Five-Ginseng Decoction Using Orthogonal Test
Optimization of Polysaccharide Extraction from <i>Astragalus</i> and Five-Ginseng Decoction Using Orthogonal Test Open
Background Astragalus and Five-Ginseng Decoction is a traditional Chinese medicine formulation designed to address symptoms of chest obstruction, heart failure, and palpitations associated with Qi and Yin deficiency and blood stasis. This …
View article: Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study
Assessing the prognosis mortality in patients with cutaneous verrucous carcinoma using Lasso-cox regression model: a retrospective study Open
View article: Neutrophil Extracellular Trap Formation Model Induced by Monosodium Urate and Phorbol Myristate Acetate: Involvement in MAPK Signaling Pathways
Neutrophil Extracellular Trap Formation Model Induced by Monosodium Urate and Phorbol Myristate Acetate: Involvement in MAPK Signaling Pathways Open
Neutrophil extracellular traps (NETs) formation is a key process in inflammatory diseases like gout, but the underlying molecular mechanisms remain incompletely understood. This study aimed to establish a model to examine the formation of …
View article: Corrigendum to “Dietary Kaempferol exerts anti-obesity effects by inducing the browning of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway” [Curr. Res. Food Sci. 8 (2024) 100728]
Corrigendum to “Dietary Kaempferol exerts anti-obesity effects by inducing the browning of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway” [Curr. Res. Food Sci. 8 (2024) 100728] Open
View article: Multiple-Wave Admixture and Adaptive Evolution of the Pamirian Wakhi People
Multiple-Wave Admixture and Adaptive Evolution of the Pamirian Wakhi People Open
While whole-genome sequencing has been applied extensively to investigate the genetic diversity of global populations, ethnic minority groups in Pakistan are generally underrepresented. In particular, little is known about the genetic orig…
View article: Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation
Kaempferol attenuates hyperuricemia combined with gouty arthritis via urate transporters and NLRP3/NF-κB pathway modulation Open
Hyperuricemia (HUA), caused by purine disorders, can lead to gouty arthritis (GA). Kaempferol (KPF), a natural flavonoid, has anti-inflammatory properties, though its mechanism in treating HUA combined with GA remains unclear. This study u…
View article: Differential effect of China’s Zero Markup Drug Policy on provider-induced demand in secondary and tertiary hospitals
Differential effect of China’s Zero Markup Drug Policy on provider-induced demand in secondary and tertiary hospitals Open
Following the marketization of China’s health system in the 1980’s, the government allowed public hospitals to markup the price of certain medications by 15% to compensate for reduced revenue from government subsidies. This incentivized cl…
View article: Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation
Optimal decision-making in relieving global high temperature-related disease burden by data-driven simulation Open
The rapid acceleration of global warming has led to an increased burden of high temperature-related diseases (HTDs), highlighting the need for advanced evidence-based management strategies. We have developed a conceptual framework aimed at…
View article: Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential
Targeting Neutrophil Extracellular Traps in Gouty Arthritis: Insights into Pathogenesis and Therapeutic Potential Open
Gouty arthritis (GA) is an immune-mediated disorder characterized by severe inflammation due to the deposition of monosodium urate (MSU) crystals in the joints. The pathophysiological mechanisms of GA are not yet fully understood, and ther…
View article: Emerging Concerns for air pollutants from chemical laboratories: Emission Characteristics, Diffusion Effects, and Ozone Formation Potential
Emerging Concerns for air pollutants from chemical laboratories: Emission Characteristics, Diffusion Effects, and Ozone Formation Potential Open
Although laboratories play a key role in scientific research at academic institutions, they pose an environmental threat because they discharge pollutants to the atmosphere. Typically, when laboratory experiments are conducted, harmful gas…
View article: Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway
Dietary kaempferol exerts anti-obesity effects by inducing the browing of white adipocytes via the AMPK/SIRT1/PGC-1α signaling pathway Open
Browning of white adipose tissue is a novel approach for the management of obesity and obesity-related metabolic disorders. Kaempferol (KPF) is a common dietary nutrient found abundantly in many fruits and vegetables and has been shown to …
View article: Unraveling the Impact of Micro- and Nano-Sized Polymethyl Methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies
Unraveling the Impact of Micro- and Nano-Sized Polymethyl Methacrylate on Gut Microbiota and Liver Lipid Metabolism: Insights from Oral Exposure Studies Open
View article: Structure–activity relationships, product species distribution and the mechanism of effect of multi-component flue gas on Hg<sup>0</sup> adsorption and oxidation over CuO/ACs
Structure–activity relationships, product species distribution and the mechanism of effect of multi-component flue gas on Hg<sup>0</sup> adsorption and oxidation over CuO/ACs Open
Distribution laws toward mercury product species and the proposed removal mechanism for Hg 0 under simulated flue gas over CuO/AC.
View article: Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression
Cognitive Phenotype Shifts in Risk-Taking: Interplay of Non-Suicidal Self-Injury Behaviors and Intensified Depression Open
Background Non-suicidal self-injury (NSSI) behavior is significantly prevalent in both adolescents and psychiatric populations, particularly in individuals with major depressive disorder (MDD). NSSI can be considered a result of risky deci…
View article: Analysis and prediction of 5-year survival in patients with cutaneous melanoma: a model-based period analysis
Analysis and prediction of 5-year survival in patients with cutaneous melanoma: a model-based period analysis Open
Background The survival and prognosis of patients are significantly threatened by cutaneous melanoma (CM), which is a highly aggressive disease. It is therefore crucial to determine the most recent survival rate of CM. This study used popu…
View article: Identification of shared biological features in four different lung cell lines infected with SARS-CoV-2 virus through RNA-seq analysis
Identification of shared biological features in four different lung cell lines infected with SARS-CoV-2 virus through RNA-seq analysis Open
The COVID-19 pandemic caused by SARS-CoV-2 has resulted in millions of confirmed cases and deaths worldwide. Understanding the biological mechanisms of SARS-CoV-2 infection is crucial for the development of effective therapies. This study …
View article: Correction: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats
Correction: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats Open
View article: Kaempferol suppresses inflammation in mice suffering from both hyperuricemia and gouty arthritis through inhibiting NLRP3 inflammasome and NF-κB pathway
Kaempferol suppresses inflammation in mice suffering from both hyperuricemia and gouty arthritis through inhibiting NLRP3 inflammasome and NF-κB pathway Open
The co-occurrence of hyperuricemia and gouty arthritis is common in patients, yet a suitable animal model for this condition is lacking. In present study, a mice model combined hyperuricemia and gouty arthritis was established. Kaempferol,…
View article: Polydatin alleviates hyperuricemia combined with gouty arthritis in mice via regulating urate transporters, NLRP3 inflammasome and NF-κB pathway
Polydatin alleviates hyperuricemia combined with gouty arthritis in mice via regulating urate transporters, NLRP3 inflammasome and NF-κB pathway Open
Gout is a metabolic disease that seriously affects people's health. Polydatin, a stilbene compound isolated from Polygonum cuspidatum, has attracted much attention because of its rich biological activity and high safety. This study aimed t…
View article: Genetic and clinical features of patients with intrahepatic cholestasis caused by citrin deficiency
Genetic and clinical features of patients with intrahepatic cholestasis caused by citrin deficiency Open
Objectives Citrin deficiency (CD) is an autosomal recessive disease caused by mutations of the SLC25A13 gene, plasma bile acid profiles detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS) could be an efficient approach fo…
View article: Allergic bronchopulmonary aspergillosis with marked peripheral blood eosinophilia and pulmonary eosinophilia: A case report
Allergic bronchopulmonary aspergillosis with marked peripheral blood eosinophilia and pulmonary eosinophilia: A case report Open
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an immune-related pulmonary disease caused by sensitization of airway by Aspergillus fumigatus. The disease manifests as bronchial asthma and recurring pulmonary shadows, which …
View article: Crafting a prognostic nomogram for the overall survival rate of cutaneous verrucous carcinoma using the surveillance, epidemiology, and end results database
Crafting a prognostic nomogram for the overall survival rate of cutaneous verrucous carcinoma using the surveillance, epidemiology, and end results database Open
Background The aim of this study was to establish and verify a predictive nomogram for patients with cutaneous verrucous carcinoma (CVC) who will eventually survive and to determine the accuracy of the nomogram relative to the conventional…
View article: Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: Prospective observational cohort study
Association of volatile anesthesia exposure and depth with emergence agitation and delirium in children: Prospective observational cohort study Open
Background Sevoflurane anesthesia is widely used in pediatric ambulatory surgery. However, emergency agitation (EA) and emergency delirium (ED), as major complications following sevoflurane anesthesia in children, pose risks to surgery and…
View article: Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats
Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats Open
Aims/introduction As a common complication in elderly patients after surgery/anesthesia, postoperative cognitive dysfunction (POCD) is mainly characterized by memory, attention, motor, and intellectual retardation. Neuroinflammation is one…
View article: Uptake of Levilactobacillus brevis JCM 1059 by THP-1 Cells via Interaction between SlpB and CAP-1 Promotes Cytokine Production
Uptake of Levilactobacillus brevis JCM 1059 by THP-1 Cells via Interaction between SlpB and CAP-1 Promotes Cytokine Production Open
Several probiotic lactic acid bacteria (LAB) exert immunomodulatory effects on the host. However, the reasons for the different effects of LAB have not been fully elucidated. To understand the different immunomodulatory effects of LAB, we …
View article: Neoisoastilbin Ameliorates Acute Gouty Arthritis via Suppression of the NF‐<i>κ</i>B/NLRP3 Pathway
Neoisoastilbin Ameliorates Acute Gouty Arthritis via Suppression of the NF‐<i>κ</i>B/NLRP3 Pathway Open
Acute gouty arthritis (AGA) is an acute inflammatory disease, whose occurrence and development mechanism are associated with inflammatory reaction of joint tissue. This study investigated the role of neoisoastilbin (NIA) in the treatment o…
View article: Development of a Rapid Zebrafish Model for Lead Poisoning Research and Drugs Screening
Development of a Rapid Zebrafish Model for Lead Poisoning Research and Drugs Screening Open
View article: Resting-State Connectivity and Response to Psychotherapy Treatment in Adolescents and Adults With OCD: A Randomized Clinical Trial
Resting-State Connectivity and Response to Psychotherapy Treatment in Adolescents and Adults With OCD: A Randomized Clinical Trial Open
The results suggest that less vmPFC-subcortical connectivity related to affect-influenced behavior may be important for ERP engagement, whereas greater cognitive-control and motor circuit connectivity may generally facilitate response to p…