Xiaoxiao Tang
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View article: Investigating biomarkers of mitochondrial and aging-related genes in major depressive disorder through bioinformatics analysis
Investigating biomarkers of mitochondrial and aging-related genes in major depressive disorder through bioinformatics analysis Open
Background Major depressive disorder (MDD) is a prevalent mental health condition in which mitochondrial dysfunction and cellular senescence contribute to its pathogenesis. This study aims to identify biomarkers related to mitochondria-ass…
View article: UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions
UBE2O-mediated ubiquitylation directs cytoplasmic CTNNA1 to promote cell-to-ECM adhesions Open
CTNNA1, a multifunctional protein that localizes at both the plasma membrane and the cytosol, plays crucial roles in actin dynamics regulation, cell-to-cell and cell-to-the extracellular matrix (ECM) adhesions and tumor suppression. Despit…
View article: Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O
Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O Open
UBE2O, an E3-independent E2 ubiquitin-conjugation enzyme, directly engages substrates to mediate Ubiquitin conjugation and ligation. Despite its critical role in ubiquitination of multiple substrates, the catalytic and regulatory mechanism…
View article: Observed Anti-parallel Correlation Between Spiral Galaxy and Cosmic Filament Spins
Observed Anti-parallel Correlation Between Spiral Galaxy and Cosmic Filament Spins Open
Understanding the origin of galactic angular momentum and its connection to the cosmic web remains a pivotal issue in galaxy formation. Using kinematic data from the MaNGA survey, we investigate the alignment between the spin directions of…
View article: Advances in functional magnetic resonance imaging research on bipolar disorder and self-stigma
Advances in functional magnetic resonance imaging research on bipolar disorder and self-stigma Open
Bipolar disorder (BD) is a chronic, recurrent, and severe mental illness. Individuals with BD often internalize prejudices and stereotypes directed toward them, leading to the development of self-stigma (SS). SS can further exacerbate impa…
View article: Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach
Mechanism of arsenic-induced liver injury in rats revealed by metabolomics and ionomics based approach Open
Arsenic (As) is an environmental toxicant and human carcinogen, long-term exposure to As can lead to varying degrees of liver injury. In this study, the liver injury model of As poisoned Sprague-Dawley (SD) rats was established, and the po…
View article: Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy
Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy Open
Background Adolescent bipolar depression (ABD) refers to depressive episodes that arise in adolescent patients with bipolar disorder. Its identification and diagnosis are challenging, and it is characterized by a high rate of misdiagnosis …
View article: Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters
Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters Open
Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for the management of the disease. This study compared and analyzed the proteins of total plasma ex…
View article: Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters
Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters Open
Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for the management of the disease. This study compared and analyzed the proteins of total plasma ex…
View article: Roxadustat for Patients with Posttransplant Anemia: A Narrative Review
Roxadustat for Patients with Posttransplant Anemia: A Narrative Review Open
Background: Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are novel oral agents used for renal anemia treatment. Roxadustat, a first-in-class HIF-PHI used for treating anemia in chronic kidney disease patients, has been…
View article: An enhanced decision-making framework for predicting future trends of sharing economy
An enhanced decision-making framework for predicting future trends of sharing economy Open
This work aims to provide a reliable and intelligent prediction model for future trends in sharing economy. Moreover, it presents valuable insights for decision-making and policy development by relevant governmental bodies. Furthermore, th…
View article: A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity
A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity Open
Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted a plasma proteomic and metabolomic study of children with ASD with and without risk genes ( de novo…
View article: SWATH proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy
SWATH proteomics analysis of placental tissue with intrahepatic cholestasis of pregnancy Open
This preliminary study helps us to understand the changes in the placental proteome of ICP patients, and provides new insights into the pathophysiology of ICP.
View article: Effects of arsenic exposure on trace element levels in the hippocampus and cortex of rats and their gender differences
Effects of arsenic exposure on trace element levels in the hippocampus and cortex of rats and their gender differences Open
Arsenic (As) exposure is a major public health challenge worldwide. Much evidence suggests that As exposure can cause disturbances in trace element balance in the body. However, there are few reports on the effect of As on trace element le…
View article: Roxadustat: Do we know all the answers?
Roxadustat: Do we know all the answers? Open
Anemia is a common complication of chronic kidney disease (CKD), and its prevalence rises as the disease progresses. Intravenous or subcutaneous erythropoiesis-stimulating agents (ESAs) are advised to treat CKD-associated anemia, since sho…
View article: Overexpression of TaSNAC4-3D in Common Wheat (Triticum aestivum L.) Negatively Regulates Drought Tolerance
Overexpression of TaSNAC4-3D in Common Wheat (Triticum aestivum L.) Negatively Regulates Drought Tolerance Open
The development and production of bread wheat ( Triticum aestivum L.) are widely affected by drought stress worldwide. Many NAC transcription factors (TFs) of stress-associated group (SNAC) are functionally proven to regulate drought toler…
View article: Two-Stage Chance-Constrained Coordinated Operation of an Integrated Gas–Electric System
Two-Stage Chance-Constrained Coordinated Operation of an Integrated Gas–Electric System Open
Under the background that the high penetration of renewable energy generation, which mainly consists of wind power, will have a significant impact on electric power systems due to the volatility and uncertainty of renewable energy, energy …
View article: Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers
Oxidative Stress in Autism Spectrum Disorder—Current Progress of Mechanisms and Biomarkers Open
Autism spectrum disorder (ASD) is a type of neurodevelopmental disorder that has been diagnosed in an increasing number of children around the world. Existing data suggest that early diagnosis and intervention can improve ASD outcomes. How…
View article: Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics
Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics Open
Arsenic (As) is one of the most important toxic elements in the natural environment. Currently, although the assessment of the potential health risks of chronic arsenic poisoning has received great attention, the research on the effects of…
View article: Genome-Wide Association Study on Root System Architecture and Identification of Candidate Genes in Wheat (Triticum aestivum L.)
Genome-Wide Association Study on Root System Architecture and Identification of Candidate Genes in Wheat (Triticum aestivum L.) Open
The root tissues play important roles in water and nutrient acquisition, environmental adaptation, and plant development. In this study, a diversity panel of 388 wheat accessions was collected to investigate nine root system architecture (…
View article: A Combined Proteomics and Metabolomics Profiling to Investigate the Genetic Heterogeneity of Autistic Children
A Combined Proteomics and Metabolomics Profiling to Investigate the Genetic Heterogeneity of Autistic Children Open
Background: Autism spectrum disorder (ASD) has become one of the most common neurological developmental disorders in children. However, the study of ASD diagnostic markers faces significant challenges due to the existence of heterogeneity.…
View article: The important roles and molecular mechanisms of annexin A2 autoantibody in children with nephrotic syndrome
The important roles and molecular mechanisms of annexin A2 autoantibody in children with nephrotic syndrome Open
Annexin A2 autoantibody may be responsible for some cases of PNS with MCD/FSGS in children.
View article: Neurometabolic alterations in bipolar disorder with anxiety symptoms: A proton magnetic resonance spectroscopy study of the prefrontal whiter matter
Neurometabolic alterations in bipolar disorder with anxiety symptoms: A proton magnetic resonance spectroscopy study of the prefrontal whiter matter Open
To identify the pathophysiological mechanism of bipolar disorder (BD) patients with anxiety symptoms, we analyzed the differences of brain biochemical metabolism in BD patients with and without anxiety symptoms. We collected 39 BD patients…
View article: The effect of multi-supportive nursing on the postoperative rehabilitation of breast cancer patients.
The effect of multi-supportive nursing on the postoperative rehabilitation of breast cancer patients. Open
Multi-supportive nursing plays a positive role in promoting patients' postoperative rehabilitation.
View article: The Impact of PM2.5 on the Host Defense of Respiratory System
The Impact of PM2.5 on the Host Defense of Respiratory System Open
The harm of fine particulate matter (PM2.5) to public health is the focus of attention around the world. The Global Burden of Disease (GBD) Study 2015 (GBD 2015 Risk Factors Collaborators, 2016) ranked PM2.5 as the fifth leading risk facto…
View article: Circulating follicular T helper cells are possibly associated with low levels of serum immunoglobulin G due to impaired immunoglobulin class-switch recombination of B cells in children with primary nephrotic syndrome
Circulating follicular T helper cells are possibly associated with low levels of serum immunoglobulin G due to impaired immunoglobulin class-switch recombination of B cells in children with primary nephrotic syndrome Open
Clinically, most patients with primary nephrotic syndrome (PNS) have low serum IgG levels, which is an important factor in infection and in PNS relapse.To some extent, the mechanisms involved remain largely unknown. Here, we aimed to inves…
View article: Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals
Peripheral invariant natural killer T cell deficiency in metabolically unhealthy but normal weight versus metabolically healthy but obese individuals Open
Objective To investigate the proportion of circulating invariant natural killer T (iNKT) cells in four body health types. Methods In this cross-sectional study, participants were classified into four body health types according to the body…