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View article: In-situ non-invasive detection of cellular reactive oxygen species by integrating Raman spectrum and bidirectional gated recurrent unit models
In-situ non-invasive detection of cellular reactive oxygen species by integrating Raman spectrum and bidirectional gated recurrent unit models Open
Cellular reactive oxygen species (ROS), a key parameter involved in cell metabolism, signaling, and apoptosis, whose detection is necessary to achieve in a variety of biological processes. However, current ROS detection methods, including …
View article: Transcriptional regulation of nucleotide metabolism in medulloblastoma subtypes and prognostic implications analyzed by RNA-Seq
Transcriptional regulation of nucleotide metabolism in medulloblastoma subtypes and prognostic implications analyzed by RNA-Seq Open
Nucleotide metabolism-transcription coupling endows MB subtypes with heterogeneity and affects prognosis. The signature is a quantitative tool for individualized risk assessment and metabolism targeted therapy.
View article: Predictive Value of <scp> <sup>18</sup> F </scp> ‐ <scp>FDG PET</scp> / <scp>CT</scp> in <scp>LA</scp> ‐ <scp>HNSCC</scp> Patients Undergoing Neoadjuvant Chemoimmunotherapy: A Prospective Study
Predictive Value of <span> <sup>18</sup> F </span> ‐ <span>FDG PET</span> / <span>CT</span> in <span>LA</span> ‐ <span>HNSCC</span> Patients Undergoing Neoadjuvant Chemoimmunotherapy: A Prospective Study Open
Objective The study evaluates the efficacy of 18 F‐2‐fluoro‐2‐deoxy‐d‐glucose FDG PET/CT in predicting outcomes in patients with advanced head and neck squamous cell carcinoma receiving neoadjuvant chemoimmunotherapy. Methods In this prosp…
View article: Artifact-free phase reconstruction for differential interference contrast microscopy based on deep learning
Artifact-free phase reconstruction for differential interference contrast microscopy based on deep learning Open
Differential interference contrast (DIC) microscopy, as a label-free, high-contrast, and strong capacity for optical section imaging method, is widely used in routine examinations of cells or tissues. However, due to the inherent non-linea…
View article: Conservative Management of Spontaneous Coronary Artery Dissection of the Left Main Coronary Artery: A Case Report
Conservative Management of Spontaneous Coronary Artery Dissection of the Left Main Coronary Artery: A Case Report Open
Spontaneous coronary artery dissection is a non-atherosclerotic cause of acute coronary syndrome, particularly among young women. A 46-year-old female without a family history of cardiac disease and traditional atherosclerotic risk factors…
View article: Learning enhanced dual-wavelength digital holography for measuring large-height complex step samples
Learning enhanced dual-wavelength digital holography for measuring large-height complex step samples Open
Nanometer-to-micron multi-step complex structures are widely used in precision manufacturing. Accurate and rapid measurement of these large-height complex step samples is crucial for product quality control and the development of manufactu…
View article: TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells
TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells Open
The risk model constructed based on the inflammation-associated ferroptosis regulators is effective to predict the clinical outcome of HCC patients. TMSB4X, involved in inflammation-associated ferroptosis, is a potential biomarker and ther…
View article: Metabolomic profiling of childhood medulloblastoma: contributions and relevance to diagnosis and molecular subtyping
Metabolomic profiling of childhood medulloblastoma: contributions and relevance to diagnosis and molecular subtyping Open
The incidence of brain tumors among children is second only to acute lymphoblastic leukemia, but the mortality rate of brain tumors has exceeded that of leukemia, making it the most common cause of death among children. Medulloblastoma (MB…
View article: Dynamic multiplexed intensity diffraction tomography using a spatiotemporal regularization-driven disorder-invariant multilayer perceptron
Dynamic multiplexed intensity diffraction tomography using a spatiotemporal regularization-driven disorder-invariant multilayer perceptron Open
Multiplexed intensity diffraction tomography (mIDT) is a technique that reconstructs the three-dimensional refractive index (3DRI) of a sample solely through intensity measurements. Using an array of light sources to generate multi-directi…
View article: DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes
DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes Open
The activation of astrocytes derived from induced pluripotent stem cells (iPSCs) is of great significance in neuroscience research, and it is crucial to obtain both cellular morphology and biomolecular information non-destructively in situ…
View article: SERS-based long-term mitochondrial pH monitoring during differentiation of human induced pluripotent stem cells to neural progenitor cells
SERS-based long-term mitochondrial pH monitoring during differentiation of human induced pluripotent stem cells to neural progenitor cells Open
As one of the important organelles in the process of cell differentiation, mitochondria regulate the whole process of differentiation by participating in energy supply and information transmission. Mitochondrial pH value is a key indicator…
View article: Prognostic significance of alterations in fibrinogen level and fibrinogen-to-lymphocyte ratio after radiotherapy on survival outcomes in glioblastoma
Prognostic significance of alterations in fibrinogen level and fibrinogen-to-lymphocyte ratio after radiotherapy on survival outcomes in glioblastoma Open
FLR was a unique and very accurate predictor for the prognosis of glioblastoma, and FIB rise after radiation was a predictive sign of poor survival. Both PTV volume and dose volume for involved organs could significantly affect the FIB and…
View article: Fresnel incoherent compressive holography toward 3D videography via dual-channel simultaneous phase-shifting interferometry
Fresnel incoherent compressive holography toward 3D videography via dual-channel simultaneous phase-shifting interferometry Open
Fresnel incoherent correlation holography (FINCH) enables high-resolution 3D imaging of objects from several 2D holograms under incoherent light and has many attractive applications in motionless 3D fluorescence imaging. However, FINCH has…
View article: Unsupervised Deep Learning Enables 3D Imaging for Single‐Shot Incoherent Holography
Unsupervised Deep Learning Enables 3D Imaging for Single‐Shot Incoherent Holography Open
Incoherent digital holography no longer requires spatial coherence of the light field, breaking through the imaging resolution of coherent digital holography. However, traditional reconstruction methods cannot avoid the inherent contradict…
View article: Adaptive phase-shifting interferometry based on a phase-shifting digital holography algorithm
Adaptive phase-shifting interferometry based on a phase-shifting digital holography algorithm Open
Phase-shifting interferometry (PSI) requires accurate phase shifts between interferograms for realizing high-accuracy phase retrieval. This paper presents an adaptive PSI through synchronously capturing phase shifts measurement interferogr…
View article: A novel immune cell signature for predicting glioblastoma after radiotherapy prognosis and guiding therapy
A novel immune cell signature for predicting glioblastoma after radiotherapy prognosis and guiding therapy Open
Background: Glioblastoma, a highly aggressive brain tumor, poses a significant clinical challenge, particularly in the context of radiotherapy. In this study, we aimed to explore infiltrating immune cells and identify immune-related genes …
View article: A Systematic Review of Studies on Public Health Status during the COVID-19 Pandemic by Visualizing their Structure using Co-Occurrence and VOSviewer Software
A Systematic Review of Studies on Public Health Status during the COVID-19 Pandemic by Visualizing their Structure using Co-Occurrence and VOSviewer Software Open
Background Since the outbreak of the COVID-19 epidemic, many public health issues have arisen. However, based on bibliometric analyses, little attention has been paid to overall trends in this area. This study sought to describe the status…
View article: Boosting nuclear-targeted photothermal-chemotherapy by NIR-responsive hybrid membrane camouflaged nanotherapeutics
Boosting nuclear-targeted photothermal-chemotherapy by NIR-responsive hybrid membrane camouflaged nanotherapeutics Open
Background Engineering nanotherapeutics have been extensively studied for cancer therapy. However, the therapeutic efficacy is still severely restricted by biophysiological barriers and intracellular accumulation. Although the biomimetic n…
View article: Moment‐Based Shape‐Learning Holography for Fast Classification of Microparticles
Moment‐Based Shape‐Learning Holography for Fast Classification of Microparticles Open
Learning-based computational in-line holography is a compact and appealing method for imaging microparticle shape and recognizing species, but it suffers from the inefficient dataset acquisition. In article number 2300120 by Jie Xu, Jindon…
View article: Moment‐Based Shape‐Learning Holography for Fast Classification of Microparticles
Moment‐Based Shape‐Learning Holography for Fast Classification of Microparticles Open
Compact computational in‐line holography based on deep learning is an attractive single‐shot approach to image microparticles dispersed in 3D volume. The particle shape contains valuable information for species classification, but the data…
View article: Supplementary Fig. S2 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S2 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
ASS1 expression in AML patients and its effect on survival
View article: Supplementary Methods from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
Supplementary Methods
View article: Supplementary Fig. S1 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S1 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
ASS1 expression in pan-cancer
View article: Supplementary Fig. S2 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S2 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
ASS1 expression in AML patients and its effect on survival
View article: Supplementary Fig. S4 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S4 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
Treatment with NEI-01 significantly inhibited cell proliferation by induction of cell cycle arrest and apoptosis in mouse ASS1-deficient C1498 cells
View article: Supplementary Fig. S3 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S3 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
ASS1 expression in AML cell lines and normal fibroblast
View article: Supplementary Fig. S4 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Fig. S4 from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
Treatment with NEI-01 significantly inhibited cell proliferation by induction of cell cycle arrest and apoptosis in mouse ASS1-deficient C1498 cells
View article: Supplementary Methods from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Methods from NEI-01-Induced Arginine Deprivation Has Potent Activity Against Acute Myeloid Leukemia Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
Supplementary Methods