Xiaoya Zhang
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View article: Study of the Micropore Structure and Tribological Properties of PTFE-Modified Porous Polyimide
Study of the Micropore Structure and Tribological Properties of PTFE-Modified Porous Polyimide Open
To address the challenges of regulating micropore properties and improving the tribological performance of porous polyimide (PPI), PPI/PTFE composites were fabricated via cold pressing–sintering. The effects of PTFE content on porosity, oi…
View article: Large Language Models (LLMs) for Evidence Synthesis: An Exploratory Evaluation and A New Approach for Automated Data Extraction
Large Language Models (LLMs) for Evidence Synthesis: An Exploratory Evaluation and A New Approach for Automated Data Extraction Open
Large language models (LLMs) are increasingly used in scientific research for their strong general problem-solving capabilities. Data extraction remains one of the most time- and labor-consuming steps in evidence synthesis (ES), making LLM…
View article: Omics-based large language models: A new engine for drug discovery innovation
Omics-based large language models: A new engine for drug discovery innovation Open
View article: Evaluating the Role of Entrepreneurship Education in Shaping Female College Students’ Career Choices in China: A Multidimensional Analysis
Evaluating the Role of Entrepreneurship Education in Shaping Female College Students’ Career Choices in China: A Multidimensional Analysis Open
This study examines the influence of entrepreneurship education on the career choices of female college students in China, focusing on four dimensions: courses, competitions, practices, and policy initiatives. Drawing on human capital and …
View article: Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase
Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase Open
Introduction Diabetes is a significant modifiable risk factor for cognitive dysfunction. There are currently no effective treatments that delay or reverse the progression of cognitive dysfunction. Accumulating evidence demonstrates that sp…
View article: Effect of intravitreal injection on optic nerve in infants with retinopathy of prematurity: a long-term follow-up study
Effect of intravitreal injection on optic nerve in infants with retinopathy of prematurity: a long-term follow-up study Open
Aims To investigate the effect of intravitreal injection (IVI) on the optic nerve in infants with retinopathy of prematurity (ROP) during long-term follow-up. Methods The preterm infants included were divided into control, untreated and tr…
View article: A prognostic model for highly aggressive prostate cancer using interpretable machine learning techniques
A prognostic model for highly aggressive prostate cancer using interpretable machine learning techniques Open
Background Extremely aggressive prostate cancer, including subtypes like small cell carcinoma and neuroendocrine carcinoma, is associated with poor prognosis and limited treatment options. This study sought to create a robust, interpretabl…
View article: Optimizing blood-brain barrier permeability in KRAS inhibitors: A structure-constrained molecular generation approach
Optimizing blood-brain barrier permeability in KRAS inhibitors: A structure-constrained molecular generation approach Open
Kirsten rat sarcoma viral oncogene homolog (KRAS) protein inhibitors are a promising class of therapeutics, but research on molecules that effectively penetrate the blood-brain barrier (BBB) remains limited, which is crucial for treating c…
View article: Enhanced Language Models for Predicting and Understanding HIV Care Disengagement: A Case Study in Tanzania
Enhanced Language Models for Predicting and Understanding HIV Care Disengagement: A Case Study in Tanzania Open
Summary Sustained engagement in HIV care and adherence to antiretroviral therapy (ART) are essential for achieving the UNAIDS "95-95-95" targets. Despite increased ART access, disengagement from care remains a significant issue, particular…
View article: Fitting item response theory models using deep learning computational frameworks
Fitting item response theory models using deep learning computational frameworks Open
PyTorch and TensorFlow are two widely adopted, modern deep learning frameworksthat offer comprehensive computation libraries for deep learning models. We illustratehow to utilize these deep learning computational platforms and infrastructu…
View article: The consequences of community exposure to firearm homicide for adolescent substance use
The consequences of community exposure to firearm homicide for adolescent substance use Open
In areas with high levels of violence, not just the individuals involved but entire communities experience harm. Acts of violence in the community that a young person did not witness or experience directly can still have consequences for t…
View article: Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment
Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment Open
There were noticeable alterations in the aqueous humor of patients with wAMD involving many metabolites that are associated with ABC transporters, glycerophospholipid metabolism, and the mammalian target of rapamycin signaling pathway. It …
View article: Foot Muscle Morphological Changes and Balance Dysfunction in Stroke: Evidence of Structural-Functional Dissociation
Foot Muscle Morphological Changes and Balance Dysfunction in Stroke: Evidence of Structural-Functional Dissociation Open
View article: Increased hip fracture risk in the patients with type 2 diabetes mellitus is correlated with urine albumin-to-creatinine ratio (ACR) and diabetes duration in men
Increased hip fracture risk in the patients with type 2 diabetes mellitus is correlated with urine albumin-to-creatinine ratio (ACR) and diabetes duration in men Open
Patients with type 2 diabetes mellitus (T2DM) have increased hip fracture risk. And the association between urine albumin to creatinine ratio (ACR) and an increased risk of hip fracture in patients with T2DM remains controversial. This stu…
View article: Investigating College Student Mental Health Needs and Barriers Using Natural Language Processing
Investigating College Student Mental Health Needs and Barriers Using Natural Language Processing Open
College students’s mental health has been declining, despite efforts by universities to improve outreach and programming. Though a variety of resources are available, students, especially those who experience marginalization, often do not …
View article: Physical exercise‐induced <scp>circAnks1b</scp> upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via <scp>miR</scp>‐130b‐5p/Pak2 signaling in an ischemic stroke model
Physical exercise‐induced <span>circAnks1b</span> upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via <span>miR</span>‐130b‐5p/Pak2 signaling in an ischemic stroke model Open
Aims Physical exercise (PE) can accelerate post‐stroke recovery. This study investigated contributions of circRNAs to PE‐induced improvements in post‐stroke neurological function. Methods Rats subjected to transient middle cerebral artery …
View article: Citrullination in health and disease: From physiological function to gene regulation
Citrullination in health and disease: From physiological function to gene regulation Open
View article: A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation
A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation Open
Histone citrullination, an important post-translational modification mediated by peptidyl arginine deiminases, is essential for many physiological processes and epigenetic regulation. However, the causal relationship between histone citrul…
View article: Physical Exercise Promotes the Protective Endoplasmic Reticulum Stress Through CircAnks1b/ miR-130-5p/ Pak2 Axis after Ischemic Stroke
Physical Exercise Promotes the Protective Endoplasmic Reticulum Stress Through CircAnks1b/ miR-130-5p/ Pak2 Axis after Ischemic Stroke Open
View article: Genome-Wide Prediction and Selection in Plant and Animal Breeding: A Systematic Review of Current Techniques
Genome-Wide Prediction and Selection in Plant and Animal Breeding: A Systematic Review of Current Techniques Open
View article: Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and G<sub>q</sub>-Biased 5-HT<sub>2C</sub> Receptor Partial Agonists
Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and G<sub>q</sub>-Biased 5-HT<sub>2C</sub> Receptor Partial Agonists Open
A series of spiropiperidines was designed and synthesized by structural modifications based on our previous lead compound 1 and evaluated with cellular signaling assays for the discovery of 5-HT2C receptor (5-HT2C
View article: Development of polymorphic microsatellite markers for <i>Fagus pashanica</i> (Fagaceae) using next-generation sequencing
Development of polymorphic microsatellite markers for <i>Fagus pashanica</i> (Fagaceae) using next-generation sequencing Open
Fagus pashanica is an endangered and endemic tree species in China. To understand its genetic diversity and structure for effective conservation, we used next-generation sequencing data to develop a set of microsatellite markers. Twenty-th…
View article: Neighborhood collective efficacy and environmental exposure to firearm homicide among a national sample of adolescents
Neighborhood collective efficacy and environmental exposure to firearm homicide among a national sample of adolescents Open
View article: Aporphines: A privileged scaffold in CNS drug discovery
Aporphines: A privileged scaffold in CNS drug discovery Open
View article: PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1
PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 Open
Protein arginine methyltransferase 5 (PRMT5) is a major type II enzyme responsible for symmetric dimethylation of arginine (SDMA), and plays predominantly roles in human cancers, including in ovarian cancer. However, the exactly roles and …
View article: Human rights, state crimes and social networking
Human rights, state crimes and social networking Open
In January 2011, the rising number of protests and revolutions in North Africa and Middle East represented a significant issue of human rights protection to the whole world. Typical revolutionary countries, such as Egypt, Libya, Tunisia, h…
View article: The mechanism of governments’ and individuals’ influence on protective behaviours during the second wave of COVID-19: a multiple mediation model
The mechanism of governments’ and individuals’ influence on protective behaviours during the second wave of COVID-19: a multiple mediation model Open
Background: The SARS-CoV-2 virus continues to spread and resurge globally with signs of a second wave, despite actions by governments to curb the COVID-19 pandemic. However, evidence-based strategies to combat COVID-19 recurrence ar…
View article: Separation and Purification of Two Saponins from Paris polyphylla var. yunnanensis by a Macroporous Resin
Separation and Purification of Two Saponins from Paris polyphylla var. yunnanensis by a Macroporous Resin Open
An effective method for separating and purifying critical saponins (polyphyllin II and polyphyllin VII) from a Paris polyphylla var. yunnanensis extract was developed in this study which was environmentally friendly and economical. Static …
View article: Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency
Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency Open
Pluripotent embryonic stem cells (ESCs) have a transcriptionally permissive chromatin environment enriched for gene activation-associated histone modifications as compared to somatic cells. A striking exception is DOT1L-mediated H3K79 meth…
View article: Heterogeneous effects of spatially proximate firearm homicide exposure on anxiety and depression symptoms among U.S. youth
Heterogeneous effects of spatially proximate firearm homicide exposure on anxiety and depression symptoms among U.S. youth Open