Xiaoyan Meng
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View article: Acquisition of Vimentin by trogocytosis inhibits the NK cell-mediated immune response against CTCs
Acquisition of Vimentin by trogocytosis inhibits the NK cell-mediated immune response against CTCs Open
Natural killer (NK) cells frequently exhibit an exhausted state, which facilitates immune escape of circulating tumour cells (CTCs). However, the underlying mechanisms of NK cell dysfunction remain elusive. In this study, we identify a nov…
View article: Design, synthesis, and biological evaluation of substituted oxopyridine derivatives as selective FXIa inhibitors
Design, synthesis, and biological evaluation of substituted oxopyridine derivatives as selective FXIa inhibitors Open
To explore selective FXIa inhibitors, a series of oxopyridine derivatives was rationally designed through CADD. With excellent in vitro potency and pharmacokinetic properties, compound 4c demonstrated higher selectivity than asundexian .
View article: Progress of Multiparameter Magnetic Resonance Imaging in Bladder Cancer: A Comprehensive Literature Review
Progress of Multiparameter Magnetic Resonance Imaging in Bladder Cancer: A Comprehensive Literature Review Open
Magnetic resonance imaging (MRI) has been proven to be an indispensable imaging method in bladder cancer, and it can accurately identify muscular invasion of bladder cancer. Multiparameter MRI is a promising tool widely used for preoperati…
View article: Evaluation of Whole-Tumor Texture Analysis Based on MRI Diffusion Kurtosis and Biparametric VI-RADS Model for Staging and Grading Bladder Cancer
Evaluation of Whole-Tumor Texture Analysis Based on MRI Diffusion Kurtosis and Biparametric VI-RADS Model for Staging and Grading Bladder Cancer Open
Background: to evaluate the feasibility of texture analysis (TA) based on diffusion kurtosis imaging (DKI) in staging and grading bladder cancer (BC) and to compare it with apparent diffusion coefficient (ADC) and biparametric vesical imag…
View article: Identification of predictive factors for outcomes after robot-assisted partial nephrectomy based on three-dimensional reconstruction of preoperative enhanced computerized tomography
Identification of predictive factors for outcomes after robot-assisted partial nephrectomy based on three-dimensional reconstruction of preoperative enhanced computerized tomography Open
Background Information from the RENAL score is limited. This study aimed to identify new parameters based on three-dimensional (3D) reconstruction of preoperative enhanced computerized tomography (CT) for predicting outcomes after robot-as…
View article: Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy
Incremental prognostic value of ADC histogram analysis in patients with high-risk prostate cancer receiving adjuvant hormonal therapy after radical prostatectomy Open
Purpose To investigate the incremental prognostic value of preoperative apparent diffusion coefficient (ADC) histogram analysis in patients with high-risk prostate cancer (PCa) who received adjuvant hormonal therapy (AHT) after radical pro…
View article: Whole-Lesion CT Texture Analysis as a Quantitative Biomarker for the Identification of Homogeneous Renal Tumors
Whole-Lesion CT Texture Analysis as a Quantitative Biomarker for the Identification of Homogeneous Renal Tumors Open
Renal tumors are very common in the urinary system, and the preoperative differential diagnosis of homogeneous renal tumors remains a challenge. This study aimed to evaluate the feasibility of the whole-lesion CT texture analysis for the i…
View article: Radiomics Nomogram Based on High-b-Value Diffusion-Weighted Imaging for Distinguishing the Grade of Bladder Cancer
Radiomics Nomogram Based on High-b-Value Diffusion-Weighted Imaging for Distinguishing the Grade of Bladder Cancer Open
Background: The aim was to evaluate the feasibility of radiomics features based on diffusion-weighted imaging (DWI) at high b-values for grading bladder cancer and to compare the possible advantages of high-b-value DWI over the standard b-…
View article: Intratumoral Tertiary Lymphoid Structures Promote Survival and Immunotherapy Response in Head Neck Squamous Cell Carcinoma
Intratumoral Tertiary Lymphoid Structures Promote Survival and Immunotherapy Response in Head Neck Squamous Cell Carcinoma Open
Tertiary lymphoid structures (TLSs) hold the potential role in the prediction of immunotherapy response in several clinical trials. TLSs in head neck squamous cell carcinoma (HNSCC) have been investigated through IHC analysis. Whereas ther…
View article: The feasibility investigation of AI -assisted compressed sensing in kidney MR imaging: an ultra-fast T2WI imaging technology
The feasibility investigation of AI -assisted compressed sensing in kidney MR imaging: an ultra-fast T2WI imaging technology Open
View article: Facile synthesis of magnetic ZnFe2O4/AC composite to activate peroxydisulfate for dye degradation under visible light irradiation
Facile synthesis of magnetic ZnFe2O4/AC composite to activate peroxydisulfate for dye degradation under visible light irradiation Open
Heterogeneous photocatalysis/persulfate oxidation process has been considered as a promising technology for dye contaminants removal. The magnetic ZnFe2O4/active carbon (AC) composites were hydrothermally synthesized …
View article: Facile Synthesis of Magnetic Znfe2o4/AC Composite to Activate Peroxydisulfate for Dye Degradation Under Visible Light Irradiation
Facile Synthesis of Magnetic Znfe2o4/AC Composite to Activate Peroxydisulfate for Dye Degradation Under Visible Light Irradiation Open
A facile hydrothermal method was employed to synthesize magnetic ZnFe 2 O 4 /active carbon (AC) composite, which was firstly used to activate peroxydisulfate (PDS) for rhodamine B (RhB) degradation under visible LED light irradiation. The …
View article: The Value of Whole-tumor CT Texture Analysis as a Quantitative Biomarker in the Identification of Solid Renal Tumors
The Value of Whole-tumor CT Texture Analysis as a Quantitative Biomarker in the Identification of Solid Renal Tumors Open
Background: Renal tumors are very common in the urinary system. Preoperative diagnosis for the renal tumor is very important for postoperative prognosis evaluation, surgical method selection, and follow-up observation. This study was to ev…
View article: Clinical and Radiological Features of Urachal Carcinoma and Infection
Clinical and Radiological Features of Urachal Carcinoma and Infection Open
Purpose To explore the clinical and radiological differences between urachal carcinoma and urachal infection. Methods Clinical and imaging information for 13 cases of urachal carcinoma and 14 cases of urachal infection confirmed by patholo…
View article: Comparison and development of preoperative systemic inflammation markers-based models for the prediction of unfavorable pathology in newly diagnosed clinical T1 renal cell carcinoma
Comparison and development of preoperative systemic inflammation markers-based models for the prediction of unfavorable pathology in newly diagnosed clinical T1 renal cell carcinoma Open
In this analytical model study, our findings verified that systemic inflammation response markers showed high potential for identifying UP. Our biomarker-based models well predicted occult aggressive histopathological characteristics among…
View article: Online Public attention and interest in COVID-19 Vaccination in mainland China (Preprint)
Online Public attention and interest in COVID-19 Vaccination in mainland China (Preprint) Open
BACKGROUND In December 2019, few cases of pneumonia were reported outbursting in the city Wuhan, Mainland China and soon became a global pandemic. With the vaccination approval in Mainland China, concerns over its safety and efficacy emer…
View article: Hemodynamic study of unenhanced magnetic resonance angiography using spatial labeling with multiple inversion pulses sequence: a phantom study
Hemodynamic study of unenhanced magnetic resonance angiography using spatial labeling with multiple inversion pulses sequence: a phantom study Open
Vascular displayed length has a linear relationship to BSP TI for flow ranges from 0.0 to 2.0 mL/s. Vascular displayed length has a linear relationship to flow rate for BSP TI values of 50 to 1,100 ms. Flow rate can be assessed in relation…
View article: Histological grades of rectal cancer: whole-volume histogram analysis of apparent diffusion coefficient based on reduced field-of-view diffusion-weighted imaging
Histological grades of rectal cancer: whole-volume histogram analysis of apparent diffusion coefficient based on reduced field-of-view diffusion-weighted imaging Open
Quantitative whole-lesion ADC histogram analysis based on the rFOV DWI technique could help differentiate histological grades of rectal cancer. The combination of ADCmean, 75th percentile, and kurtosis may be the best choice.
View article: Living Donor Liver Transplantation in Biliary Atresia Children with Pulmonary Hypertension
Living Donor Liver Transplantation in Biliary Atresia Children with Pulmonary Hypertension Open
LDLT is a safe procedure in a selected group of BA patients with PH, however, further long-term clinical investigations and mechanical researches are needed.
View article: High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen-activated protein kinase signaling pathway
High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen-activated protein kinase signaling pathway Open
The present study aimed to determine the effects of high mobility group box 1 protein (HMGB1) on myocardial ischemia reperfusion (I/R) injury in rats following acute myocardial ischemia and investigate the underlying molecular mechanisms o…
View article: Differentiating malignant from benign gastric mucosal lesions with quantitative analysis in dual energy spectral computed tomography
Differentiating malignant from benign gastric mucosal lesions with quantitative analysis in dual energy spectral computed tomography Open
To investigate the value of quantitative analysis in dual energy spectral computed tomography (DESCT) for differentiating malignant gastric mucosal lesions from benign gastric mucosal lesions (including gastric inflammation [GI] and normal…
View article: Assessing the Early Response of Advanced Cervical Cancer to Neoadjuvant Chemotherapy Using Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging
Assessing the Early Response of Advanced Cervical Cancer to Neoadjuvant Chemotherapy Using Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging Open
D and ADC values may be useful for predicting and monitoring the efficacy of NACT in cervical cancer. An IVIM model may be equal to monoexponential model in predicting and monitoring the efficacy of NACT in cervical cancer.
View article: Nonmuscle-invasive and Muscle-invasive Urinary Bladder Cancer
Nonmuscle-invasive and Muscle-invasive Urinary Bladder Cancer Open
This study compared the imaging quality, diagnostic accuracy, and apparent diffusion coefficient (ADC) values of reduced field-of-view (rFOV) diffusion-weighted imaging (DWI) and full field-of-view (fFOV) single-shot echo-planar imaging wi…
View article: Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study ⁎
Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study ⁎ Open
Objective The aim of this study was to investigate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) to diagnose cervical cancer and to evaluate the response of uterine cervical cancer t…
View article: Preliminary clinical application of an adaptive iterative statistical reconstruction algorithm inhead and neck computed tomography angiography with low tube voltage and a low concentration of contrast medium
Preliminary clinical application of an adaptive iterative statistical reconstruction algorithm inhead and neck computed tomography angiography with low tube voltage and a low concentration of contrast medium Open
Objective To evaluate the feasibility of using a low concentration of contrast medium (Visipaque 270 mgI/mL), low tube voltage, and an advanced image reconstruction algorithm in head and neck computed tomography angiography (CTA). Methods …
View article: Endoscopic mucosal resection of duodenal bulb adenocarcinoma with neuroendocrine features: An extremely rare case report
Endoscopic mucosal resection of duodenal bulb adenocarcinoma with neuroendocrine features: An extremely rare case report Open
Duodenal adenocarcinoma, especially duodenal bulb with neuroendocrine features (NEF), is extremely rare. Here, we report one such case of duodenal bulb adenocarcinoma with neuroendocrine features. A 63-year-old Han Chinese woman was admitt…