Xiaoyan Nie
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Author Swipe
View article: Prevalence and characteristics of off-label use of antidepressants in paediatric patients in China
Prevalence and characteristics of off-label use of antidepressants in paediatric patients in China Open
View article: Efficacy and Safety of Biologics for Systemic Lupus Erythematosus (SLE): A Systematic Review and Network Meta-Analysis
Efficacy and Safety of Biologics for Systemic Lupus Erythematosus (SLE): A Systematic Review and Network Meta-Analysis Open
This study aimed to use Bayesian network meta-analysis to compare the efficacy and safety of biologics for systemic lupus erythematosus (SLE). A comprehensive and systematic search of electronic databases (PubMed, Medline, Cochrane Library…
View article: Research on the Construction methods of the "Engineering Ideology and Politics" Case Library in the Context of Production-Education Integration - Taking the Provincial First-Class Course FPGA as an Example
Research on the Construction methods of the "Engineering Ideology and Politics" Case Library in the Context of Production-Education Integration - Taking the Provincial First-Class Course FPGA as an Example Open
In response to the challenges faced by ideological and political education within the context of production-education integration, this paper proposes the development and reform of a course-based ideological and political education case li…
View article: Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China
Treatment indications for antidepressants prescribed in primary health care facilities in Beijing, China Open
To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of a…
View article: Discordances between molecular profiling and precision oncology drug selection of non-small cell lung cancer in China
Discordances between molecular profiling and precision oncology drug selection of non-small cell lung cancer in China Open
Background: Precision oncology drugs are a class of targeted drugs that are most effective in a molecularly defined subset of cancer patients. Pretreatment molecular profiling is integral to optimal patient selection. However, discordances…
View article: Chinese Physicians’ Preference for Prescribing Brand-Name vs. Generic: A Discrete Choice Experiment
Chinese Physicians’ Preference for Prescribing Brand-Name vs. Generic: A Discrete Choice Experiment Open
Background: Promoting the use of generic drugs is a viable strategy to control drug costs. As physicians have a critical role in deciding on what drugs to prescribe and thus whether certified generic drugs were actually used, this study ai…
View article: Efficacy and Safety of Janus Kinase Inhibitors in Patients with Vitiligo: A Systematic Review and Meta‐Analysis
Efficacy and Safety of Janus Kinase Inhibitors in Patients with Vitiligo: A Systematic Review and Meta‐Analysis Open
Although several case reports and small clinical trials have reported promising outcomes with Janus kinase (JAK) inhibitors for vitiligo, high‐quality evidence and guidelines are lacking. We evaluated the efficacy and safety of JAK inhibit…
View article: Failure mode and effects analysis-based strategies for controlling multidrug-resistant organism infections in cancer patients
Failure mode and effects analysis-based strategies for controlling multidrug-resistant organism infections in cancer patients Open
In the context of advancing medical procedures, postoperative infections in cancer patients, particularly those involving multidrug-resistant organisms, have become a significant clinical concern. This study aims to comprehensively and sys…
View article: Characteristics of rheumatoid arthritis clinical trials over past decade 2013-2023: current landscape and opportunities for improvement
Characteristics of rheumatoid arthritis clinical trials over past decade 2013-2023: current landscape and opportunities for improvement Open
Background There is a disconnection between the continued pressing clinical demand for rheumatoid arthritis (RA) treatments and the saturation of the current therapeutic markets. The design of rheumatoid arthritis trials might represent on…
View article: Microbiome and metabolome analyses reveal significant alterations of gut microbiota and bile acid metabolism in ETEC-challenged weaned piglets by dietary berberine supplementation
Microbiome and metabolome analyses reveal significant alterations of gut microbiota and bile acid metabolism in ETEC-challenged weaned piglets by dietary berberine supplementation Open
This study mainly investigated the effects of berberine (BBR) on the bile acid metabolism in gut-liver axis and the microbial community in large intestine of weaned piglets challenged with enterotoxigenic Escherichia coli (ETEC) by microbi…
View article: Influencing Factors of Generic Prescribing Behavior of Physicians: A Structural Equation Model Based on the Theory of Planned Behavior
Influencing Factors of Generic Prescribing Behavior of Physicians: A Structural Equation Model Based on the Theory of Planned Behavior Open
Physicians' attitudes, subjective norms, and perceived behavioral control were significant positive correlation predictors of behavioral intention. Subjective norms and perceived behavior control had a greater impact than attitude on physi…
View article: Off-Label Use of Antidepressants Among Pediatric Patients in China
Off-Label Use of Antidepressants Among Pediatric Patients in China Open
View article: Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin
Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin Open
Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could …
View article: Infection Control Strategies for MDRO Based on Failure Mode and Effects Analysis: An Empirical Study on Postoperative Infections in Cancer Patients
Infection Control Strategies for MDRO Based on Failure Mode and Effects Analysis: An Empirical Study on Postoperative Infections in Cancer Patients Open
Objective This study aims to comprehensively and systematically evaluate the effectiveness of infection prevention and control for multidrug-resistant organisms (MDROs) in postoperative cancer patients using Failure Mode and Effects Analys…
View article: Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review
Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review Open
Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we …
View article: A new perspective on variation of voriconazole steady-state valley concentration in Chinese population: CYP2C19 DNA methylation
A new perspective on variation of voriconazole steady-state valley concentration in Chinese population: CYP2C19 DNA methylation Open
Background: Voriconazoleis(VRC) often used in complex therapeutic environments for the treatment and prevention of invasive fungal infections. The steady-state valley concentration (Cminss) of VRC not only varies between individuals, but a…
View article: Potent and broad HIV-neutralizing antibodies in memory B cells and plasma
Potent and broad HIV-neutralizing antibodies in memory B cells and plasma Open
Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. Antibody 10E8, reactive with the distal portion of the membrane-proximal external region (MPER) of HIV-1 gp41, is broadly neutralizing. However, t…
View article: Effectiveness and safety of anti-BCMA chimeric antigen receptor T-cell treatment in relapsed/refractory multiple myeloma: a comprehensive review and meta-analysis of prospective clinical trials
Effectiveness and safety of anti-BCMA chimeric antigen receptor T-cell treatment in relapsed/refractory multiple myeloma: a comprehensive review and meta-analysis of prospective clinical trials Open
Background: Chimeric antigen receptor T cells treatment targeting B cell maturation antigen (BCMA) is an emerging treatment option for relapsed/refractory multiple myeloma (RRMM) and has demonstrated outstanding outcomes in clinical studie…
View article: The Impact of Prescribing Monitoring Policy on Drug Use and Expenditures in China: A Multi-center Interrupted Time Series Study
The Impact of Prescribing Monitoring Policy on Drug Use and Expenditures in China: A Multi-center Interrupted Time Series Study Open
Background: A prescribing monitoring policy (PMP) was implemented in November 2015 in Anhui province, China, the first province to pilot this policy to manage the use and costs of select drugs based on their large prescription volumes and/…
View article: Traditional Chinese medicine for frozen shoulder: An evidence‐based guideline
Traditional Chinese medicine for frozen shoulder: An evidence‐based guideline Open
Background Frozen shoulder is a common disorder that can lead to long‐lasting impairment in shoulder‐related daily activities. Traditional Chinese medicine (TCM) has played an important role in the effort to manage frozen shoulder. Purpose…
View article: Pharmacists’ Views on Unmet Needs of Patients with Cancer and Pharmaceutical Care in Specialty Pharmacy: A Qualitative Analysis
Pharmacists’ Views on Unmet Needs of Patients with Cancer and Pharmaceutical Care in Specialty Pharmacy: A Qualitative Analysis Open
Objectives This study aimed to understand the perspective of pharmacists on cancer patients’ needs and the most meaningful pharmaceutical care in specialty pharmacies. Methods Semi-structured interviews were conducted with pharmacists work…
View article: Physicians’ Knowledge, Attitude, and Experience of Pharmacogenomic Testing in China
Physicians’ Knowledge, Attitude, and Experience of Pharmacogenomic Testing in China Open
(1) Background: As prescribers, physicians play a decisive role in applying and promoting pharmacogenomic (PGx) testing in clinical practices. So far, little is known about physicians’ perspectives on PGx testing in China. The aim of this …
View article: Cardiovascular adverse events in chronic myeloid leukemia patients treated with nilotinib or imatinib: A systematic review, meta-analysis and integrative bioinformatics analysis
Cardiovascular adverse events in chronic myeloid leukemia patients treated with nilotinib or imatinib: A systematic review, meta-analysis and integrative bioinformatics analysis Open
Objective The aim of this article is to assess the risk and potential mechanisms of cardiovascular adverse events in patients treated with nilotinib or imatinib by conducting a systematic review, meta-analysis and integrative bioinformatic…
View article: Trends in the utilization of psychotropic medications in China from 2018 to 2021
Trends in the utilization of psychotropic medications in China from 2018 to 2021 Open
Background: Monitoring psychotropic medicine consumption trends can provide information on the extent of pharmacological interventions for mental disorders and availability of psychotropic medicines. Objectives: This study aimed to illustr…
View article: Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect
Link between sterile inflammation and cardiovascular diseases: Focus on cGAS-STING pathway in the pathogenesis and therapeutic prospect Open
Sterile inflammation characterized by unresolved chronic inflammation is well established to promote the progression of multiple autoimmune diseases, metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, collectivel…
View article: Clinical Pharmacists’ Knowledge of and Attitudes toward Pharmacogenomic Testing in China
Clinical Pharmacists’ Knowledge of and Attitudes toward Pharmacogenomic Testing in China Open
(1) Background: Uptake of pharmacogenomic testing in routine clinical practices is currently slow in China. Pharmacists might play an important role in leveraging care through applying pharmacogenomics, therefore, it is important to better…
View article: Influences of Dietary Vitamin E, Selenium-Enriched Yeast, and Soy Isoflavone Supplementation on Growth Performance, Antioxidant Capacity, Carcass Traits, Meat Quality and Gut Microbiota in Finishing Pigs
Influences of Dietary Vitamin E, Selenium-Enriched Yeast, and Soy Isoflavone Supplementation on Growth Performance, Antioxidant Capacity, Carcass Traits, Meat Quality and Gut Microbiota in Finishing Pigs Open
This study investigated the effects of dietary compound antioxidants on growth performance, antioxidant capacity, carcass traits, meat quality, and gut microbiota in finishing pigs. A total of 36 barrows were randomly assigned to 2 treatme…
View article: Clinical Pharmacists’ Involvement in Pharmacogenomics Testing and Related Services in China
Clinical Pharmacists’ Involvement in Pharmacogenomics Testing and Related Services in China Open
Background: Pharmacogenomics (PGx) testing is increasingly used in clinical practice to optimize drug therapies. This study aims to understand the involvement of clinical pharmacists in PGx testing at tertiary hospitals in China and their …
View article: Pharmacogenomics of Leukotriene Modifiers: A Systematic Review and Meta-Analysis
Pharmacogenomics of Leukotriene Modifiers: A Systematic Review and Meta-Analysis Open
Pharmacogenetics research on leukotriene modifiers (LTMs) for asthma has been developing rapidly, although pharmacogenetic testing for LTMs is not yet used in clinical practice. We performed a systematic review and meta-analysis on the imp…
View article: A Randomized Controlled Dose-Escalation Study of LY06006, a Recombinant Humanized Monoclonal Antibody to RANKL, in Chinese Healthy Adults
A Randomized Controlled Dose-Escalation Study of LY06006, a Recombinant Humanized Monoclonal Antibody to RANKL, in Chinese Healthy Adults Open
Background: This study was conducted to explore the safety, tolerance, pharmacokinetics, pharmacodynamics, and immunogenicity of LY06006, a recombinant humanized monoclonal antibody to RANKL, when administrated subcutaneously in Chinese he…