Xiaoyan Lin
YOU?
Author Swipe
View article: PRSS22 as a novel prognostic and immune regulatory biomarker in PanCancer multiomics analysis
PRSS22 as a novel prognostic and immune regulatory biomarker in PanCancer multiomics analysis Open
Serine proteases are key mediators of tumorigenesis; however, the pan-cancer significance of PRSS22 remains poorly defined. This study comprehensively analyzes the multi-omics landscape and clinical relevance of PRSS22 across 33 cancer typ…
View article: Development and evaluation of a comprehensive Patient for Medication Safety (PFMS) intervention programme to improve participation in medication safety behaviours among older adults with chronic disease during hospital-to-home transition: a pilot randomized controlled trial
Development and evaluation of a comprehensive Patient for Medication Safety (PFMS) intervention programme to improve participation in medication safety behaviours among older adults with chronic disease during hospital-to-home transition: a pilot randomized controlled trial Open
This trial was retrospectively registered on 18 April 2024 in the China Clinical Trial Registry (ChiCTR2400083215).
View article: Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial
Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial Open
Ascentage Pharma Group Corp Ltd. (Hong Kong).
View article: Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe
Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe Open
Dopamine, a catecholamine neurotransmitter found in both neural tissue and body fluids, plays a critical role in brain function. Its distribution in specific brain regions affects the coordination of pituitary endocrine functions and is di…
View article: Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma
Chimeric SF-25 monoclonal antibody as a targeted therapy for SLC3A2 in adult T-cell leukemia/lymphoma Open
The SF-25 antigen (SF-25 Ag), which functions as the amino acid transporter solute carrier family 3 member 2 (SLC3A2), is essential for regulatory T (Treg) cell maintenance and is highly expressed in adult T-cell leukemia/lymphoma (ATL) ce…
View article: Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma
Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma Open
This study highlights that FBXO45 is highly expressed in patients with HCC with TP53 mutations. FBXO45 promotes HCC lung metastasis by activating the TFG-ATF2-NF-κB-epithelial-mesenchymal transition signaling axis. In addition, we found th…
View article: Risk factors and predictive models for secondary hemorrhage in pediatric coblation tonsillectomy
Risk factors and predictive models for secondary hemorrhage in pediatric coblation tonsillectomy Open
Severe tonsillar embedding, junior surgeon, obesity, poor postoperative diet, and age ≥12 years are independent risk factors for Coblation SPTH in children. The Nomogram model can quickly and efficiently calculate the bleeding rate of SPTH…
View article: Comparison of Remimazolam-Flumazenil and Propofol on Psychomotor Function and Emergence Following General Anesthesia in Surgical Abortion: A Randomized Controlled Trial
Comparison of Remimazolam-Flumazenil and Propofol on Psychomotor Function and Emergence Following General Anesthesia in Surgical Abortion: A Randomized Controlled Trial Open
ChiCTR2300075375, date of registration: 03/09/2023.
View article: Network pharmacology‑based analysis and <i>in vitro</i> experimental verification of the inhibitory role of luteoloside on gastric cancer cells via the p53/p21 pathway
Network pharmacology‑based analysis and <i>in vitro</i> experimental verification of the inhibitory role of luteoloside on gastric cancer cells via the p53/p21 pathway Open
The present study aimed to investigate the inhibitory effect of luteoloside on the proliferation, migration and invasion of gastric cancer (GC) cells based on network pharmacology and in vitro experiments. GC-associated targets were obtain…
View article: Camrelizumab plus carboplatin and pemetrexed as first-line therapy for advanced non-squamous non-small-cell lung cancer: 5-year outcomes of the CameL randomized phase 3 study
Camrelizumab plus carboplatin and pemetrexed as first-line therapy for advanced non-squamous non-small-cell lung cancer: 5-year outcomes of the CameL randomized phase 3 study Open
Background CameL phase 3 study demonstrated the superiority of camrelizumab plus chemotherapy over chemotherapy alone for progression-free survival in patients with previously untreated advanced non-squamous non-small-cell lung cancer (NSC…
View article: Participation in medication safety of older-adult patients with chronic disease during the transition from hospital to home: a descriptive qualitative study
Participation in medication safety of older-adult patients with chronic disease during the transition from hospital to home: a descriptive qualitative study Open
Patient participation is important in ensuring medication safety during the hospital to family transition period. This study highlights that older-adult patients' participation in medication safety includes three aspects: participation in …
View article: Developing a Sitting Simple Baduanjin program for advanced cancer patients with the fatigue-sleep disturbance symptom cluster: A feasibility study
Developing a Sitting Simple Baduanjin program for advanced cancer patients with the fatigue-sleep disturbance symptom cluster: A feasibility study Open
Objectives We describe a development and feasibility study of a Sitting Simple Baduanjin program for advanced cancer patients suffering from the fatigue–sleep disturbance symptom cluster. This study was to evaluate the practicality and saf…
View article: Determination of the effective dose of remimazolam combined with sufentanil for inhibiting body movement during surgical abortion: An up-and-down sequential allocation trial
Determination of the effective dose of remimazolam combined with sufentanil for inhibiting body movement during surgical abortion: An up-and-down sequential allocation trial Open
Background: Remimazolam, a recently developed anesthetic characterized by its rapid and ultra-short-acting properties, exhibits pharmacological attributes that make it potentially suitable for painless surgical abortion procedures. The obj…
View article: Enhancing Stoma Care Quality: Implementing a PDSA Cycle-Based Program for Colorectal Cancer Patients
Enhancing Stoma Care Quality: Implementing a PDSA Cycle-Based Program for Colorectal Cancer Patients Open
Background: Effective quality management is of prime importance in reducing the risk of ostomy’s complications. It is necessary to improve the quality of stoma practice specialist and increase patients' awareness of self-care and the need …
View article: Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis
Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis Open
To sum up, LDA significantly improved neonatal outcomes in pregnant women at high risk of PE without elevating the risk of placental abruption. These findings support LDA's clinical application in pregnant women, although further research …
View article: Detection and clinical analysis of human coronavirus infection with acute respiratory tract infection in children in the Xiamen area, China, in 2021-2023
Detection and clinical analysis of human coronavirus infection with acute respiratory tract infection in children in the Xiamen area, China, in 2021-2023 Open
Purpose:To investigate human coronavirus (HCoV) infection with acute respiratory tract infection in children in the Xiamen area, China, and to analyze the clinical features of HCoV infection in children. Methods: A total of 15 283 children…
View article: A novel approach to evaluation of tumor response for advanced pulmonary adenocarcinoma using the intertumoral heterogeneity response score
A novel approach to evaluation of tumor response for advanced pulmonary adenocarcinoma using the intertumoral heterogeneity response score Open
Treatment response and prognosis estimation in advanced pulmonary adenocarcinoma are challenged by the significant heterogeneity of the disease. The current Response Evaluation Criteria in Solid Tumors (RECIST) criteria, despite providing …
View article: 61P First-line camrelizumab (Camre) plus carboplatin (Carbo) and pemetrexed (Pem) for advanced non-squamous NSCLC: 5-yr outcomes of CameL phase III study
61P First-line camrelizumab (Camre) plus carboplatin (Carbo) and pemetrexed (Pem) for advanced non-squamous NSCLC: 5-yr outcomes of CameL phase III study Open
In the CameL phase III study (NCT03134872), Camre + Carbo-Pem was superior to Carbo-Pem for PFS in patients (pts) with previously untreated, advanced non-squamous NSCLC without EGFR/ALK alterations. Here, we present the updated outcomes af…
View article: A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer
A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer Open
Purpose This investigation sought to examine the efficacy and safety of low-dose apatinib used alongside chemotherapy in the clinical management of patients with metastatic triple-negative breast cancer (TNBC) within a real-world setting, …
View article: A case of cardiac undifferentiated pleomorphic sarcoma in late pregnancy: A case report
A case of cardiac undifferentiated pleomorphic sarcoma in late pregnancy: A case report Open
Cardiac tumors are uncommon and most of them are benign. Although cases of malignant cardiac tumors are rare, it is still necessary to improve awareness in both clinical and pathological diagnosis. Since cardiac tumors often have a high de…
View article: Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
Toripalimab Plus Chemotherapy for Recurrent or Metastatic Nasopharyngeal Carcinoma Open
Importance There are currently no therapies approved by the US Food and Drug Administration for nasopharyngeal carcinoma (NPC). Gemcitabine-cisplatin is the current standard of care for the first-line treatment of recurrent or metastatic N…
View article: Existential distress and associated factors in advanced cancer patients: a cross-sectional study
Existential distress and associated factors in advanced cancer patients: a cross-sectional study Open
Objective: This study aimed to investigate the current state of existential distress and identify its associated factors in advanced cancer patients. Methods: A cross-sectional study was conducted among 352 advanced cancer patients from th…