Xiaoyang Hua
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View article: Decoding intertumoral heterogeneity in multifocal ground-glass nodule lung cancers: Clonal evolutionary insight for precision management
Decoding intertumoral heterogeneity in multifocal ground-glass nodule lung cancers: Clonal evolutionary insight for precision management Open
View article: Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia
Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia Open
The nasal mucosa is an important component of mucosal immunity. Immunogenic particles in inspired air are known to activate the local nasal mucosal immune system and can lead to sinonasal inflammation; however, little is known about the ef…
View article: Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents
Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents Open
Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte inj…
View article: Nasal virus infection induces asthma exacerbation through B‐cell‐dependent recruitment of inflammatory monocytes
Nasal virus infection induces asthma exacerbation through B‐cell‐dependent recruitment of inflammatory monocytes Open
Background Upper respiratory viral infections (URVIs) are responsible for 80% of asthma exacerbation episodes. However, the underlying mechanisms remain poorly understood. Methods In this study, we used a mouse model of URVI and examined t…
View article: Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness
Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness Open
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Ou…
View article: 504 Topical adenosine treatment inhibits inflammation and mucus production in viral acute rhinosinusitis
504 Topical adenosine treatment inhibits inflammation and mucus production in viral acute rhinosinusitis Open
OBJECTIVES/GOALS: Viral acute rhinosinusitis (ARS), a.k.a, the common cold, affects millions every year. The symptoms caused by viral ARS dramatically affect the general well-being and functional levels of patients, causing work and school…
View article: Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis
Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis Open
Objective Viral acute rhinosinusitis (ARS) is the leading cause of work and school absence and antibiotic over‐prescription. There are limited treatment options available to ameliorate the symptoms caused by viral ARS. We have previously d…
View article: A Steadier Hand: The First Human Clinical Trial of a Single-Use Robotic-Assisted Surgical Device for Cochlear Implant Electrode Array Insertion
A Steadier Hand: The First Human Clinical Trial of a Single-Use Robotic-Assisted Surgical Device for Cochlear Implant Electrode Array Insertion Open
Objective To evaluate the safety and utility of an investigational robotic-assisted cochlear implant insertion system. Study Design Prospective, single-arm, open-label study under abbreviated Investigational Device Exemption requirements. …
View article: Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness
Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness Open
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Ou…
View article: Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells
Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells Open
Lung cancer is one of the most common forms of cancer and accounts for a significant proportion of all cancer‑related deaths. Lung adenocarcinoma (LUAD) accounts for approximately 40% of all cases of lung cancer. In recent years, new devel…
View article: Enhanced mast cell activation in mice deficient in the A2b adenosine receptor
Enhanced mast cell activation in mice deficient in the A2b adenosine receptor Open
Antigen-mediated cross-linking of IgE bound to mast cells via the high affinity receptor for IgE triggers a signaling cascade that results in the release of intracellular calcium stores, followed by an influx of extracellular calcium. The …
View article: Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells
Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells Open
The mechanisms responsible for the development of airway hyperresponsiveness in asthma are poorly understood. Adenosine levels are high in the lungs of patients with asthma, but a role for adenosine in the development of this cardinal feat…
View article: Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice
Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice Open
The contribution of NLRP3, a member of the nucleotide-binding domain leucine-rich repeat containing (NLR) family, in the development of allergic airway disease is currently controversial. Here, we used multiple allergic asthma models to ex…
View article: IL-4 Amplifies the Pro-Inflammatory Effect of Adenosine in Human Mast Cells by Changing Expression Levels of Adenosine Receptors
IL-4 Amplifies the Pro-Inflammatory Effect of Adenosine in Human Mast Cells by Changing Expression Levels of Adenosine Receptors Open
Adenosine inhalation produces immediate bronchoconstriction in asthmatics but not in normal subjects. The bronchospastic effect of adenosine is largely mediated through adenosine-induced mast cell activation, the mechanism of which is poor…
View article: Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice
Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice Open
Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental trigger. Calcitonin gene-related peptide (CGRP) is a neuropeptide that may have a pa…
View article: High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma
High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma Open
SH3 domain‑containing kinase‑binding protein 1 (CIN85), an 85 kDa protein known to be a member of the signal adaptor family, is abnormally expressed in several human malignancies and has been found to be involved in the growth, migration a…
View article: MyD88 provides a protective role in long-term radiation-induced lung injury
MyD88 provides a protective role in long-term radiation-induced lung injury Open
The role of innate immune regulators is investigated in injury sustained from irradiation as in the clinic for cancer treatment or from a nuclear incident. The protective benefits of flagellin signaling through Toll-like receptors (TLR) in…
View article: The Chemokine, CCL3, and Its Receptor, CCR1, Mediate Thoracic Radiation–Induced Pulmonary Fibrosis
The Chemokine, CCL3, and Its Receptor, CCR1, Mediate Thoracic Radiation–Induced Pulmonary Fibrosis Open
Patients receiving thoracic radiation often develop pulmonary injury and fibrosis. Currently, there are no effective measures to prevent or treat these conditions. We tested whether blockade of the chemokine, CC chemokine ligand (CCL) 3, a…
View article: Pulmonary Immune Responses to Propionibacterium acnes in C57BL/6 and BALB/c Mice
Pulmonary Immune Responses to Propionibacterium acnes in C57BL/6 and BALB/c Mice Open
Propionibacterium acnes (PA) is a gram-positive anaerobic bacterium implicated as a putative etiologic agent of sarcoidosis. To characterize the pulmonary immune response to PA, C57BL/6 and BALB/c mice were intraperitoneally sensitized and…
View article: Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection
Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection Open
Background Viral infections and exposure to oxidant air pollutants are two of the most important inducers of asthma exacerbation. Our previous studies have demonstrated that exposure to diesel exhaust increases the susceptibility to influe…
View article: Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia
Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia Open
The nasal mucosa is an important component of mucosal immunity. Immunogenic particles in inspired air are known to activate the local nasal mucosal immune system and can lead to sinonasal inflammation; however, little is known about the ef…
View article: Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome–CoV infection Open
Oxidative stress and chronic low-grade inflammation in the lungs are associated with aging and may contribute to age-related immune dysfunction. To maintain lung homeostasis, chronic inflammation is countered by enhanced expression of pror…