Explanipedia

Predictive Models for Single-Droplet Ignition in Static High-Temperature Air in Different Gravity Environments Open

Xiaoyang Lan, Huilong Zheng, Yu Fang, Xianzhang Peng, Xiaofang Yang , et al. · 2025

To address the design and optimization of the ignition system for the microgravity single-droplet combustion experiment module within the Combustion Science Experimental System (CSES) aboard the Chinese Space Station (CSS), it is essential…

Numerical Simulation Study on the Feasibility of Cyclone PIV Tracer Particle Seeder in Microgravity Open

Xianzhang Peng, Huilong Zheng, Yu Fang, Xiaoyang Lan, Xiaofang Yang , et al. · 2025

The Particle Image Velocimetry (PIV) Unit in the Combustion Science Experimental System (CSES) aboard the China Space Station (CSS) is designed for flow field measurements in microgravity combustion experiments. However, the lack of a reli…

Clinical characteristics, etiology, and treatment of young adult‐onset epilepsy: A 24‐year retrospective study Open

Xu Zhang, Feng Xiang, Ziyu Wang, Yang Li, Chenjing Shao , et al. · 2024

Objective To analyze the clinical characteristics, etiology, drug treatment, and related factors of patients with young adult‐onset epilepsy. Methods The study included patients with epilepsy aged between 18 and 44 years and aimed to analy…

Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis Open

Jingshuang Yan, Huixin Chen, Yan Zhang, Lihua Peng, Zi-Kai Wang , et al. · 2024

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to respiratory failure, and eventually death. However, there is a lack of effective treatments for ALS. Here we report the results of fecal microbiot…

Burnout and fatigue amongst internal medicine residents: A cross-sectional study on the impact of alternative scheduling models on resident wellness Open

J Yuan, Huang Yiming, Brianna K. Rosgen, Sarah Donnelly, Xiaoyang Lan , et al. · 2023

Background Fatigue and burnout are prevalent among resident physicians across Canada. Shifts exceeding 24 hours are commonly purported as detrimental to resident health and performance. Residency training programs have employed strategies …

Clarifying the role of adjuvant therapy after multi-agent neoadjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma Open

Xiaoyang Lan, Omar Abdel‐Rahman · 2023

Systemic Lupus Erythematosus: Initial Manifestation as Cardiac Tamponade? Open

Zechen Ma, Xiaoyang Lan, Kevin R. Bainey · 2023

A 49-year-old man presented with 1 hour of retrosternal chest pain and ST-segment elevation. In the ambulance, he was diagnosed with an ST-segment elevation myocardial infarction and received prompt fibrinolysis. On arrival to the percutan…

Challenges in Diagnosis and Treatment of Pancreatic Exocrine Insufficiency among Patients with Pancreatic Ductal Adenocarcinoma Open

Xiaoyang Lan, Gabrielle Robin, Jessica Kasnik, Grace Lai‐Hung Wong, Omar Abdel‐Rahman · 2023

Pancreatic ductal adenocarcinoma (PDAC) is the most common malignancy of the pancreas and is associated with an extremely poor prognosis. Many PDAC patients suffer from profound nutritional complications such as nutrient deficiencies, weig…

Exploring the Relationship between Obesity, Metabolic Syndrome and Neuroendocrine Neoplasms Open

Xiaoyang Lan, Nicola Fazio, Omar Abdel‐Rahman · 2022

Obesity is a major burden for modern medicine, with many links to negative health outcomes, including the increased incidence of certain cancer types. Interestingly, some studies have supported the concept of an “Obesity Paradox”, where so…

Protective role of lidocaine against cerebral ischemia‑reperfusion injury: An <i>in vitro</i> study Open

Xiaoyang Lan, Yumin Xu · 2021

Lidocaine, a local anesthetic, is a valuable agent for the treatment of neuronal ischemia/reperfusion (I/R) injury. The aim of the present study was to investigate the role of lidocaine in oxygen-glucose deprivation/reperfusion (OGD/R)-ind…

Accuracy of the Short-Form Montreal Cognitive Assessment Chinese Versions Open

Jiping Tan, Xiaoxiao Wang, Shimin Zhang, Yiming Zhao, Xiaoyang Lan , et al. · 2021

Background: There is a strong need for short and effective methods to screen for cognitive impairment. Recent studies have created short forms of the Montreal Cognitive Assessment (s-MoCA) in English-speaking populations. It is also import…

PRMT5 inhibition disrupts splicing and stemness in glioblastoma Open

Patty Sachamitr, Jolene Caifeng Ho, Felipe E. Ciamponi, Wail Ba-Alawi, Fiona J. Coutinho , et al. · 2021

Central nervous system aspergillosis in immunocompetent patients Open

Yubao Ma, Wanjun Li, Ran Ao, Xiaoyang Lan, Yang Li , et al. · 2020

The aim of this study was to investigate the clinical characteristics of central nervous system (CNS) aspergillosis in immunocompetent patients. This study enrolled six immunocompetent patients diagnosed with CNS aspergillosis. Additionall…

Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2+ Granule Neuron Precursor Open

Hayden Selvadurai, Erika Luis, Kinjal Desai, Xiaoyang Lan, Maria Vladoiu , et al. · 2020

Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development. Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows hierarchically, with Sox2⁺ cells at the apex of tumor progression and rel…

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma Open

Cyril Neftel, Julie Laffy, Mariella G. Filbin, Toshiro Hara, Marni E. Shore , et al. · 2019

Isolation and functional characterization of human glioblastoma stem cells Open

Xiaoyang Lan, Xiaoyang Lan, Lilian Lee, Michelle Kushida, Clare Che , et al. · 2017

glioblastoma stem cells.

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells Open

Nicole I. Park, Paul Guilhamon, Kinjal Desai, Rochelle F. McAdam, Ellen Langille , et al. · 2017

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy Open

Xiaoyang Lan, David J. Jörg, Florence M.G. Cavalli, Laura M. Richards, Long Nguyen , et al. · 2017

Functional Divergence of Glioblastoma Stem Cells Open

Xiaoyang Lan · 2017

Genetic heterogeneity in cancer is well-established using genomic sequencing, while functional assays of prospectively isolated cancer subsets have demonstrated the existence of developmental programs in many hematological and solid malign…

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells Open

Sonam Dolma, Hayden Selvadurai, Xiaoyang Lan, Lilian Lee, Michelle Kushida , et al. · 2016

MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin Open

Marco Gallo, Fiona J. Coutinho, Robert J. Vanner, Tenzin Gayden, Stephen C. Mack , et al. · 2015

Awareness Status of Chronic Disabling Neurological Diseases among Elderly Veterans Open

Jiping Tan, Lin-Qi Zhu, Jun Zhang, Shimin Zhang, Xiaoyang Lan , et al. · 2015

The awareness of CDND among elderly veterans was significantly lower than that of CCD. More information about CDND should be disseminated by health care professionals. Appropriate guidance will promote the rapid and extensive dissemination…

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity Open

Mona Meyer, Jüri Reimand, Xiaoyang Lan, Renee Head, Xueming Zhu , et al. · 2015

Significance Glioblastoma is an incurable brain tumor. It is characterized by intratumoral phenotypic and genetic heterogeneity, but the functional significance of this heterogeneity is unclear. We devised an integrated functional and geno…

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