Xiaoyi Liu
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View article: Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion
Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion Open
Objective To identify common functional brain networks underlying heterogeneous gray matter (GM) correlates of extraversion and to characterize the neurotransmitter receptor and transporter architecture associated with these networks. Meth…
View article: Dual-Head Pix2Pix Network for Material Decomposition of Conventional CT Projections with Photon-Counting Guidance
Dual-Head Pix2Pix Network for Material Decomposition of Conventional CT Projections with Photon-Counting Guidance Open
Material decomposition in X-ray imaging is essential for enhancing tissue differentiation and reducing the radiation dose, but the clinical adoption of photon-counting detectors (PCDs) is limited by their high cost and technical complexity…
View article: Green manure intercropping reshapes beneficial microbial consortia to enhance soil multifunctionality and agroecosystem resilience
Green manure intercropping reshapes beneficial microbial consortia to enhance soil multifunctionality and agroecosystem resilience Open
Intercropping crops with green manure offers a sustainable strategy to reduce nitrogen fertilizer dependency, enhance yields, and improve land use efficiency. While beneficial soil microorganisms are known to be key drivers of improved soi…
View article: Multi‐omics identifies microbiota‐derived deoxycholic acid as a key mediator of blood‐brain barrier dysfunction in Parkinson's disease
Multi‐omics identifies microbiota‐derived deoxycholic acid as a key mediator of blood‐brain barrier dysfunction in Parkinson's disease Open
The gut microbiota derived from Parkinson's disease patients, enriched in Bacteroides fragilis (B. fragilis) and Phocaeicola vulgatus (P. vulgatus), may promote the elevations of deoxycholic acid, iso-deoxycholi…
View article: Global burden of skin cancer and its subtypes: a comprehensive analysis from 1990 to 2021 with projections to 2040
Global burden of skin cancer and its subtypes: a comprehensive analysis from 1990 to 2021 with projections to 2040 Open
Background Skin cancer represents a significant global public health concern. Comprehensive analysis of its global burden provides critical insights for evidence-based interventions. This study systematically evaluates the global disease b…
View article: Cu2+/Cu+ redox-cycling-driven dual-mode sensor for simultaneous monitoring of acetylcholinesterase activity and pesticide exposure
Cu2+/Cu+ redox-cycling-driven dual-mode sensor for simultaneous monitoring of acetylcholinesterase activity and pesticide exposure Open
Introduction The procedural complexity and time-consuming of conventional pesticide residue detection methods in traditional Chinese medicines (TCMs) significantly impeded their application in modern systems. To address this, this study pr…
View article: Cepharanthine Enhances MHC-I Antigen Presentation and Anti-Tumor Immunity in Melanoma via Autophagy Inhibition
Cepharanthine Enhances MHC-I Antigen Presentation and Anti-Tumor Immunity in Melanoma via Autophagy Inhibition Open
Major histocompatibility complex class I (MHC-I)-mediated antigen presentation plays a pivotal role in anti-tumor immunity by enabling CD8+ T cells to recognize and eliminate malignant cells. In melanoma, modulation of this pathway is crit…
View article: Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis
Cell-free DNA fragmentomic characteristics in transposon elements inform molecular regulators and enhance cancer diagnosis Open
Fragmentomics of plasma cell-free DNA (cfDNA) are emerging diagnostic biomarkers in cancer liquid biopsy, while the molecular regulations of cfDNA fragmentation remain elusive. In this study, we investigated the cfDNA fragmentomics in tran…
View article: A case report and literature review on new-onset systemic lupus erythematosus leading to thrombocytopenia in a hemodialysis patient
A case report and literature review on new-onset systemic lupus erythematosus leading to thrombocytopenia in a hemodialysis patient Open
Rationale: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects various organs. Disease activity in SLE may diminish following the initiation of dialysis in patients with end-stage renal disease. Patient concern:…
View article: <scp>PDGF</scp>‐D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the <scp>NF</scp>‐<scp>κB</scp>/<scp>NOTCH1</scp> Pathway
<span>PDGF</span>‐D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the <span>NF</span>‐<span>κB</span>/<span>NOTCH1</span> Pathway Open
Background Platelet‐derived growth factor‐D (PDGF‐D) is expressed at high levels in various tumors and is involved in epithelial–mesenchymal transition (EMT) and the malignant behavior of cancer cells. However, its role in glioma progressi…
View article: hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer
hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer Open
Ovarian cancer has the highest mortality rate among gynecologic tumors worldwide, with unclear underlying mechanisms of pathogenesis. RNA-binding proteins (RBPs) primarily direct post-transcriptional regulation through modulating RNA metab…
View article: Peripheral Blood Plasminogen Activator Inhibitor 1 and Tissue-Type Plasminogen Activator-Inhibitor Complex Levels for the Diagnosis and Prediction Value of Venous Thromboembolism in Malignant Tumors
Peripheral Blood Plasminogen Activator Inhibitor 1 and Tissue-Type Plasminogen Activator-Inhibitor Complex Levels for the Diagnosis and Prediction Value of Venous Thromboembolism in Malignant Tumors Open
Context.— Patients with malignant tumors complicated by venous thromboembolism (VTE) face high mortality rates because of a lack of effective diagnostic and predictive markers. Plasminogen activator inhibitor 1 (PAI-1) and tissue-type plas…
View article: Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship
Pharmacological mechanisms of probenecid for SARS-CoV-2 and RSV co-infection: findings of system pharmacology, molecular docking, molecular dynamics simulation, and structure–activity relationship Open
Background The clinical consequences of the co-infection with novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and respiratory syncytial virus (RSV) are not optimistic. Nevertheless, there is currently no approved therape…
View article: Protocol for the analysis of cell-free DNA end characteristics for accurate cancer diagnosis
Protocol for the analysis of cell-free DNA end characteristics for accurate cancer diagnosis Open
View article: Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China
Serum IL-6 and IL-10 levels are associated with fatal outcomes in patients with SFTS in China Open
Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with a high mortality rate and is a public health concern. This study aimed to investigate the associations of serum interleukin 6 (IL-6) an…
View article: Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation
Tetrandrine augments melanoma cell immunogenicity via dual inhibition of autophagic flux and proteasomal activity enhancing MHC-I presentation Open
MHC-I-mediated antigen presentation is pivotal in antitumor immunity, enabling the recognition and destruction of tumor cells by CD8 + T cells. Both the proteasome and autophagy serve as essential cellular degradation mechanisms that regul…
View article: <i>Muribaculum intestinale</i> restricts <i>Salmonella</i> Typhimurium colonization by converting succinate to propionate
<i>Muribaculum intestinale</i> restricts <i>Salmonella</i> Typhimurium colonization by converting succinate to propionate Open
Insufficient dietary fiber intake is associated with dysbiosis and compromised colonization resistance (CR) to enteric infections. However, a detailed understanding of the relationship between dietary fiber insufficiency and CR remains elu…
View article: ATPase Inhibitory Factor 1 Drives Mitochondrial Energy Metabolic Reprogramming to Promote HCC Vasculogenic Mimicry via the ESR1/miR-20a-3p/GNAZ Pathway
ATPase Inhibitory Factor 1 Drives Mitochondrial Energy Metabolic Reprogramming to Promote HCC Vasculogenic Mimicry via the ESR1/miR-20a-3p/GNAZ Pathway Open
Vasculogenic mimicry (VM) is a microcirculation pattern that has a crucial effect on hepatocellular carcinoma (HCC) metastasis. In this study, leveraging the GeneCard and The Cancer Genome Atlas databases, we identified ATPase inhibitory f…
View article: Knowledge Spillover of Green Innovation: Carbon Emission Responses to Exploitation and Exploration
Knowledge Spillover of Green Innovation: Carbon Emission Responses to Exploitation and Exploration Open
View article: Clinical and molecular genetic analysis of Silver Russell syndrome caused by PLAG1 gene deletion: a five-year follow-up and literature review
Clinical and molecular genetic analysis of Silver Russell syndrome caused by PLAG1 gene deletion: a five-year follow-up and literature review Open
View article: Expression pattern of glutaminase informs the dynamics of glutamine metabolism
Expression pattern of glutaminase informs the dynamics of glutamine metabolism Open
Glutamine is an essential nutrient that plays critical roles in both normal physiological processes and disease pathogenesis. In this study, we introduce a quantitative approach to trace the dynamics of glutamine metabolism by monitoring t…
View article: InterFormer: Effective Heterogeneous Interaction Learning for Click-Through Rate Prediction
InterFormer: Effective Heterogeneous Interaction Learning for Click-Through Rate Prediction Open
Click-through rate (CTR) prediction, which predicts the probability of a user clicking an ad, is a fundamental task in recommender systems. The emergence of heterogeneous information, such as user profile and behavior sequences, depicts us…
View article: Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis Open
View article: Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosis
Cell-free DNA end characteristics enable accurate and sensitive cancer diagnosis Open
View article: In vivo evaluation of guide-free Cas9-induced safety risks in a pig model
In vivo evaluation of guide-free Cas9-induced safety risks in a pig model Open
View article: Fibrinogen-to-prealbumin and C-reactive protein-to-prealbumin ratios as prognostic indicators in severe fever with thrombocytopenia syndrome
Fibrinogen-to-prealbumin and C-reactive protein-to-prealbumin ratios as prognostic indicators in severe fever with thrombocytopenia syndrome Open
Background The primary aim of this study is to investigate the correlation between serum levels of fibrinogen-to-prealbumin ratio (FPR) and C-reactive protein-to-prealbumin ratio (CPR) and prognostic outcomes among patients with severe fev…
View article: Systematic biases in reference-based plasma cell-free DNA fragmentomic profiling
Systematic biases in reference-based plasma cell-free DNA fragmentomic profiling Open
Plasma cell-free DNA (cfDNA) fragmentation patterns are emerging directions in cancer liquid biopsy with high translational significance. Conventionally, the cfDNA sequencing reads are aligned to a reference genome to extract their fragmen…
View article: Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology
Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology Open
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor trans…
View article: Exonuclease editor promotes precision of gene editing in mammalian cells
Exonuclease editor promotes precision of gene editing in mammalian cells Open
Background Many efforts have been made to improve the precision of Cas9-mediated gene editing through increasing knock-in efficiency and decreasing byproducts, which proved to be challenging. Results Here, we have developed a human exonucl…
View article: Enhancing prime editor flexibility with coiled-coil heterodimers
Enhancing prime editor flexibility with coiled-coil heterodimers Open
Background Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of prime editors (PEs) h…