Xiaoyuan Han
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View article: Current AI Applications and Challenges in Oral Pathology
Current AI Applications and Challenges in Oral Pathology Open
Artificial intelligence (AI), particularly through machine learning (ML) and deep learning (DL) techniques such as convolutional neural networks (CNNs) and natural language processing (NLP), has shown remarkable promise in image analysis a…
View article: Pancreatic hepatoid carcinoma: a case report.
Pancreatic hepatoid carcinoma: a case report. Open
We analyzed the previous PHC-related literature to enhance the understanding of PHC and persistently improve PHC treatment strategies for clinicians.
View article: Impact of Fructose‐Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats
Impact of Fructose‐Enhanced Solid and Soft Drink Diets on Metabolism, Physiology, and Gut Microbiome in Pregnant Rats Open
Introduction: High fructose consumption is linked to hypertension and metabolic disorders. We hypothesize fructose (solid and/or liquid) may further influence dietary patterns. To investigate potential effects, we compared eating behaviors…
View article: Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes
Sexual Dimorphism in Impairment of Acetylcholine-Mediated Vasorelaxation in Zucker Diabetic Fatty (ZDF) Rat Aorta: A Monogenic Model of Obesity-Induced Type 2 Diabetes Open
Several reports, including our previous studies, indicate that hyperglycemia and diabetes mellitus exert differential effects on vascular function in males and females. This study examines sex differences in the vascular effects of type 2 …
View article: miRNAs mediate the impact of smoking on dental pulp stem cells via the p53 pathway
miRNAs mediate the impact of smoking on dental pulp stem cells via the p53 pathway Open
Cigarette smoke changes the genomic and epigenomic imprint of cells. In this study, we investigated the biological consequences of extended cigarette smoke exposure on dental pulp stem cells (DPSCs) and the potential roles of miRNAs. DPSCs…
View article: Spatial subsetting enables integrative modeling of oral squamous cell carcinoma multiplex imaging data
Spatial subsetting enables integrative modeling of oral squamous cell carcinoma multiplex imaging data Open
The following folders/files are part of this repository: Zip-Archive "OSCC-IMC-Einhaus2023" contains all the data and code necessary reproduce all analysis steps: Folder "UOPCohort": Contains all data and code regarding the OSCC cohort col…
View article: Cigarette smoking exposure disrupts the regenerativepotential of dental pulp stem cells
Cigarette smoking exposure disrupts the regenerativepotential of dental pulp stem cells Open
These findings suggest that cigarette smoke exposure alters the regenerative abilities of DPSCs in various ways. Future studies are warranted to further characterize the underlying molecular mechanisms of smoking-mediated damage to DPSCs, …
View article: Journal of Dental Education Volume 87 Number S1/June 2023
Journal of Dental Education Volume 87 Number S1/June 2023 Open
Journal of Dental Education is published in 15 issues per year.FTE-based pricing, based on the overall demand and on the size and type of the subscribing institution (academic, government, hospital or corporate), applies for this Journal.
View article: An exam blueprinting case for measuring student application of biomedical sciences to clinical sciences
An exam blueprinting case for measuring student application of biomedical sciences to clinical sciences Open
The Integrated National Board Dental Examination (INBDE), which assesses the ability to apply fundamental knowledge in a problem-solving context, focuses on evaluating the future dental practitioner's ability to integrate basic sciences kn…
View article: Understanding the tumor microenvironment in head and neck squamous cell carcinoma
Understanding the tumor microenvironment in head and neck squamous cell carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors. While significant progress has been made using multimodal treatment, the 5‐year survival remains at 50%. Developing effective therapies, such as immu…
View article: A Peripheral Immune Signature of Labor Induction
A Peripheral Immune Signature of Labor Induction Open
Approximately 1 in 4 pregnant women in the United States undergo labor induction. The onset and establishment of labor, particularly induced labor, is a complex and dynamic process influenced by multiple endocrine, inflammatory, and mechan…
View article: Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum
Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum Open
Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood. We provide a comprehensive single-cell depiction of the neonatal immune system at …
View article: Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset Open
Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology.
View article: Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies
Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies Open
The study aim was to discover bio-signatures predicting the risk of preeclampsia in two independent cohorts (Stanford and Detroit) of pregnant women using a highly-multiplexed and aptamer-based proteomic array (SomaLogic).
View article: Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19 Open
The biological determinants of the wide spectrum of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, basal signaling activity, and si…
View article: Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset Open
Peripheral blood metabolomic, proteomic, and immune cell dynamics in the 100 days preceding spontaneous laborbefore delivery predict labor onset and reveal a transition from pregnancy progression to pre-labor biology
View article: Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset Open
Peripheral blood metabolomic, proteomic, and immune cell dynamics in the 100 days preceding spontaneous laborbefore delivery predict labor onset and reveal a transition from pregnancy progression to pre-labor biology
View article: Multiomics Longitudinal Modeling of Preeclamptic Pregnancies
Multiomics Longitudinal Modeling of Preeclamptic Pregnancies Open
Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear and that poses a threat to both mothers and infants. Specific complex changes in women's physiology precede a diagnosis of preeclampsia. Understanding mul…
View article: Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries
Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries Open
This study analyzed multiomics data of plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in low- and middle-income countries. The comparative analysis of Cell-free transcriptomics,…
View article: How to Develop Role Positioning Strategies in Place Brand Internationalization
How to Develop Role Positioning Strategies in Place Brand Internationalization Open
This research is based on the perspective of Moral legitimacy to develop place role positioning strategies and enrich the place role positioning theory. The place role positioning strategy developed in this research can provide place brand…
View article: Integration of Mechanistic Immunological Knowledge into a Machine Learning Pipeline Increases Predictive Power
Integration of Mechanistic Immunological Knowledge into a Machine Learning Pipeline Increases Predictive Power Open
The dense network of interconnected cellular signaling responses quantifiable in peripheral immune cells provide a wealth of actionable immunological insights. While high-throughput single-cell profiling techniques, including polychromatic…