Jian Ding
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View article: 1342 First-in-human dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and initial efficacy of mRNA-LNP MT-302 <i>in vivo</i> CAR therapy in solid tumors
1342 First-in-human dose escalation study to investigate the safety, pharmacokinetics, pharmacodynamics and initial efficacy of mRNA-LNP MT-302 <i>in vivo</i> CAR therapy in solid tumors Open
View article: Multicenter epidemiological investigation and analysis of factors associated with transient synovitis of the hip in 5065 children treated across 32 tertiary children’s hospitals in China
Multicenter epidemiological investigation and analysis of factors associated with transient synovitis of the hip in 5065 children treated across 32 tertiary children’s hospitals in China Open
View article: Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy
Cancer‐Associated Fibroblasts: Origin, Classification, Tumorigenicity, and Targeting for Cancer Therapy Open
Cancer‐associated fibroblasts (CAFs) are pivotal stromal components that shape the tumor microenvironment through their remarkable heterogeneity and dynamic functions. This review comprehensively examines the biology of CAFs, starting with…
View article: Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation
Fe-MOF loaded with capmatinib to reverse immunosuppressive microenvironment and inhibit tumor metastasis after radiofrequency ablation Open
Incomplete radiofrequency ablation (iRFA) of hepatocellular carcinoma (HCC) has the risk to exacerbate the tumor immunosuppressive microenvironment and promote lung metastasis. There is an urgent need to reverse the immunosuppressive micro…
View article: Thrombolytic therapy efficacy in cardiopulmonary resuscitation: Investigating the effect of recombinant tissue plasminogen activator (Review)
Thrombolytic therapy efficacy in cardiopulmonary resuscitation: Investigating the effect of recombinant tissue plasminogen activator (Review) Open
Cardiopulmonary resuscitation (CPR) involves a series of urgent life‑saving actions performed to manually revive a person in cardiac arrest. In >70% of CPR cases, the primary health deterioration is due to acute myocardial infarction or a …
View article: Crosstalk between dysregulated amino acid sensing and glucose and lipid metabolism in colorectal cancer
Crosstalk between dysregulated amino acid sensing and glucose and lipid metabolism in colorectal cancer Open
Cancer cells reprogram the metabolism of glucose, lipids, and proteins (amino acids) to meet their energy needs during tumor initiation and progression. Amino acid sensing pathways play rucial roles in the progression and spread of colorec…
View article: Phosphatase and tensin homolog accelerate the inflammatory injury and glycolysis of chondrocytes through TP53 protein-mediated p38MAPK pathway activation in a high-glucose environment
Phosphatase and tensin homolog accelerate the inflammatory injury and glycolysis of chondrocytes through TP53 protein-mediated p38MAPK pathway activation in a high-glucose environment Open
Objective: Chronic metabolic diseases represent a high-risk factor for osteoarthritis. In particular, diabetes has been proven to be closely related to the occurrence of osteoarthritis in cases called diabetic osteoarthritis (DAO). A large…
View article: NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathways
NINJ1 promotes lung adenocarcinoma progression via activation of the PI3K-AKT signaling axis and suppression of cell death pathways Open
Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality, and current therapeutic options often fail to yield sustained responses. Ninjurin1 (NINJ1), a transmembrane protein implicated in plasma membrane rupture durin…
View article: Recent advances in EZH2 inhibitor research
Recent advances in EZH2 inhibitor research Open
View article: Prognostic value of Naples prognostic score for locally advanced gastric cancer after neoadjuvant chemoimmunotherapy
Prognostic value of Naples prognostic score for locally advanced gastric cancer after neoadjuvant chemoimmunotherapy Open
NPS is a significant prognostic indicator and can be a reliable predictor of survival in LAGC patients underwent radical resection after NCIT.
View article: Bio‐Inspired Structural Color Irises as Physical Unclonable Functions for Anti‐Counterfeiting
Bio‐Inspired Structural Color Irises as Physical Unclonable Functions for Anti‐Counterfeiting Open
The global proliferation of high‐value commodities has the intensified demand for advanced anti‐counterfeiting solutions. Physical Unclonable Functions (PUFs) present a viable authentication mechanism, yet existing implementations exhibit …
View article: Bile acid metabolism and hcepatocellular carcinoma: mechanisms of drug resistance and intervention strategies
Bile acid metabolism and hcepatocellular carcinoma: mechanisms of drug resistance and intervention strategies Open
Hepatocellular carcinoma (HCC) is the predominant malignant liver tumor, characterized by high morbidity, mortality, and rapid progression, and it ranks among the leading causes of cancer-related fatalities worldwide. Its treatment is faci…
View article: PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors
PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors Open
The hyperactivation of the PI3K pathway in head and neck squamous cell carcinoma (HNSCC) suggests that targeting PI3K is a potential therapeutic strategy. CYH33 is a novel PI3Kα-selective inhibitor discovered by our group, which is current…
View article: Manipulating alternative end-joining alters carbon-ion beam-induced genome mutation profiles in <i>Arabidopsis thaliana</i>
Manipulating alternative end-joining alters carbon-ion beam-induced genome mutation profiles in <i>Arabidopsis thaliana</i> Open
DNA double-strand breaks (DSBs) repair via POLQ-mediated alternative end-joining (Alt-EJ) is error-prone and mutagenic. However, Alt-EJ is often inhibited by classical nonhomologous end-joining (C-NHEJ) or homologous recombination, the pre…
View article: Bioinspired cilia-based electronic skin for multimodal mechanical sensing via additive manufacturing
Bioinspired cilia-based electronic skin for multimodal mechanical sensing via additive manufacturing Open
Electronic skin (e-skin) has been widely used in various fields such as health monitoring, robotic tactile perception, and bioinspired prosthetics due to its ability to detect a wide range of signals. However, traditional flexible e-skin i…
View article: Advancing radiation-induced mutant screening through high-throughput technology: a preliminary evaluation of mutant screening in Arabidopsis thaliana
Advancing radiation-induced mutant screening through high-throughput technology: a preliminary evaluation of mutant screening in Arabidopsis thaliana Open
View article: Particle-size dependent of bacterial diversity associated with suspended particulate matter continuum in Lake Taihu
Particle-size dependent of bacterial diversity associated with suspended particulate matter continuum in Lake Taihu Open
Suspended particulate matter (SPM) of varying particle sizes is widespread in aquatic ecosystems, providing crucial habitats for bacteria and serving as hotspots for mineralization and nutrient cycling. However, prior studies have typicall…
View article: Mechanism of astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique
Mechanism of astragaloside A against lung adenocarcinoma based on network pharmacology combined with molecular dynamics simulation technique Open
View article: Deciphering the molecular transcriptomic mechanisms of carbon ion beams and X-ray on rice seedlings
Deciphering the molecular transcriptomic mechanisms of carbon ion beams and X-ray on rice seedlings Open
View article: USP7 V517F mutation as a mechanism of inhibitor resistance
USP7 V517F mutation as a mechanism of inhibitor resistance Open
View article: Multifocal cancer is associated with better survival than solitary cancer in non-Hispanic White patients with thyroid carcinoma
Multifocal cancer is associated with better survival than solitary cancer in non-Hispanic White patients with thyroid carcinoma Open
Multifocal thyroid carcinoma is associated with better CSS and OS than solitary cancer in NHW patients.
View article: Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors
Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors Open
Branched-chain amino acid aminotransferases (BCATs), existing as the two isoforms BCAT1 and BCAT2, are responsible for the catabolism of branched-chain amino acids (BCAAs) and are highly upregulated and implicated in a diverse range of can…
View article: Distilling implicit multimodal knowledge into large language models for zero-resource dialogue generation
Distilling implicit multimodal knowledge into large language models for zero-resource dialogue generation Open
View article: Predictive value of the Chinese Visceral Adiposity Index for disease activity and vedolizumab response in ulcerative colitis
Predictive value of the Chinese Visceral Adiposity Index for disease activity and vedolizumab response in ulcerative colitis Open
Objective: ulcerative colitis (UC) is characterized by chronic nonspecific inflammation of the intestinal tract. The identification of non-invasive biomarkers that can reflect intestinal inflammation and predict therapeutic response is vit…
View article: Frontier and Hot Topics In Magnetoencephalography(Meg) in Neurological Diseases: A Bibliometric Analysis (2000-2024)
Frontier and Hot Topics In Magnetoencephalography(Meg) in Neurological Diseases: A Bibliometric Analysis (2000-2024) Open
View article: The Roles of CBX4 in Gastrointestinal Cancer
The Roles of CBX4 in Gastrointestinal Cancer Open
Chromobox 4 (CBX4) is a polycomb group protein involved in epigenetic regulation via the polycomb repressive complex 1 (PRC1) and its small ubiquitin-like modifier (SUMO) ligase activity. It has been reported that CBX4 plays several oncoge…
View article: Efficient Tuning of Large Language Models for Knowledge-Grounded Dialogue Generation
Efficient Tuning of Large Language Models for Knowledge-Grounded Dialogue Generation Open
Large language models (LLMs) demonstrate remarkable text comprehension and generation capabilities but often lack the ability to utilize up-to-date or domain-specific knowledge not included in their training data. To address this gap, we i…
View article: Additively Manufactured Flexible EGaIn Sensor for Dynamic Detection and Sensing on Ultra-Curved Surfaces
Additively Manufactured Flexible EGaIn Sensor for Dynamic Detection and Sensing on Ultra-Curved Surfaces Open
Electronic skin is widely employed in multiple applications such as health monitoring, robot tactile perception, and bionic prosthetics. In this study, we fabricated millimeter-scale electronic skin featuring compact sensing units using th…
View article: Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect
Discovery of a non‐nucleotide stimulator of interferon genes (STING) agonist with systemic antitumor effect Open
Agonists of the stimulator of interferon genes (STING) pathway are increasingly being recognized as a promising new approach in the treatment of cancer. Although progress in clinical trials for STING agonists in antitumor applications has …
View article: Multicenter epidemiological analysis of related factors in 10,808 hospitalized children with lower limb and pelvic fractures in China
Multicenter epidemiological analysis of related factors in 10,808 hospitalized children with lower limb and pelvic fractures in China Open