Xiaoli Ge
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View article: Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of cluster of differentiation 38 as an early biomarker
Clinical manifestations of anxiety and depression in sepsis-associated encephalopathy and multi-omics identification of cluster of differentiation 38 as an early biomarker Open
BACKGROUND Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, characterized by cognitive impairment, altered consciousness, and psychiatric symptoms, including anxiety and depression. These psychiatric symptoms ofte…
View article: A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults
A phase I, randomized, placebo‐controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults Open
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. Nirsevimab, an extended half‐life monoclonal antibody against RSV, is approved in China for the prevention of RSV lowe…
View article: Causal role of immune cells in diabetic nephropathy: a bidirectional Mendelian randomization study
Causal role of immune cells in diabetic nephropathy: a bidirectional Mendelian randomization study Open
Background Diabetic nephropathy (DN) stands as a pervasive chronic renal disease worldwide, emerging as the leading cause of renal failure in end-stage renal disease. Our objective is to pinpoint potential immune biomarkers and evaluate th…
View article: Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway
Quercetin-loaded mesoporous nano-delivery system remodels osteoimmune microenvironment to regenerate alveolar bone in periodontitis via the miR-21a-5p/PDCD4/NF-κB pathway Open
Background Impaired osteo-/angiogenesis, excessive inflammation, and imbalance of the osteoimmune homeostasis are involved in the pathogenesis of the alveolar bone defect caused by periodontitis. Unfortunately, there is still a lack of ide…
View article: Metabolomic analysis of hydroxycinnamic acid inhibition on Saccharomyces cerevisiae
Metabolomic analysis of hydroxycinnamic acid inhibition on Saccharomyces cerevisiae Open
View article: P922 Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridium difficile infection
P922 Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridium difficile infection Open
Background Clostridium difficile infection (CDI) is common in patients with inflammatory bowel disease (IBD) and has been reported as a risk factor for poor outcome. However, gut microbiome and mycobiome of IBD patients with CDI have been …
View article: Volatile Fatty Acids Bio-Production Using Extracellular Polymeric Substances Disengaged from Sludge for Carbon Source Recycling in Wwtp: A Novel Cost-Effective Strategy
Volatile Fatty Acids Bio-Production Using Extracellular Polymeric Substances Disengaged from Sludge for Carbon Source Recycling in Wwtp: A Novel Cost-Effective Strategy Open
View article: Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice
Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice Open
P. aeruginosa strains are most capable of inducing ALI/ARDS in mice among major clinical pathogenic bacteria tested, and this ability is specifically attributed to their LasB production.
View article: Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway
Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway Open
View article: Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis
Inhibition of miR-19a protects neurons against ischemic stroke through modulating glucose metabolism and neuronal apoptosis Open
View article: Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia
Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia Open
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood. Autophagy plays an important role in neuronal apoptosis induced by ischemia. However, whether autophagy i…