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Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage Open

Andrew Murley, Ann Catherine Popovici, Xiaozhou Hu, Amanda W. Lund, Kevin Wickham , et al. · 2025

To maintain tissue homeostasis, many cells reside in a quiescent state until prompted to divide. The reactivation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfolded protein…

Genetic and Epigenetic Aberrations of SOX7 in Newly Diagnosed and Relapsed Multiple Myeloma as Well as Related Neoplasms Open

Can Küçük, Burcu Akman, Xiaozhou Hu, Tevfik Hatipoğlu, Ahmet Şeyhanlı , et al. · 2025

Multiple myeloma (MM) is one of the most frequent hematological malignancies. Most MM cases relapse, which is associated with poor prognosis. MM-related tumor suppressor genes are not totally known yet. SOX7 is one of the tumor suppressor …

Correction: Potential diagnostic and prognostic biomarkers of pediatric Burkitt lymphoma identified through miRNA expression profiling Open

Can Küçük, Esra Esmeray Sönmez, Tevfik Hatipoğlu, Hongling Yuan, Xiaozhou Hu , et al. · 2024

Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage Open

Andrew Murley, Ann Catherine Popovici, Xiaozhou Hu, Amanda W. Lund, Kevin Wickham , et al. · 2024

Summary To maintain tissue homeostasis, many cells are kept in a quiescent state until prompted to divide. The re-activation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfol…

Multi-Year QTL Mapping and RNA-seq Reveal Candidate Genes for Early Floret-Opening Time in Japonica Rice Open

Xiaozhou Hu, Guoliang Chen, Rui Zhang, Mengxuan Xu, Ling Zhao , et al. · 2023

Floret-opening time (FOT) refers to the time between florets opening and closing within a day, and is a crucial agricultural trait for reproductive development, thermal tolerance and hybrid breeding in rice. However, little is known about …

Table S3 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S3. This table(Supplementary Table 3)shows the genes with the best evidence for being silenced by promoter methylation.

Supplemental Methods and Results from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Supplemental Methods and Results. Supplemental file including methods for GEP, RRBS, pyrosequencing, q-RT-PCR, western blot, functional assays, additional statistical methods and results describing the enrichment of tumor suppressor genes …

Table S2 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S2. Basic sequencing statistics of NK samples

Supplemental Methods and Results from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Supplemental Methods and Results. Supplemental file including methods for GEP, RRBS, pyrosequencing, q-RT-PCR, western blot, functional assays, additional statistical methods and results describing the enrichment of tumor suppressor genes …

Table S1 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S1. Pathological characteristics and available data of NK-cell lymphoma cases (A) and NK cell lines (B).

Table S3 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S3. This table(Supplementary Table 3)shows the genes with the best evidence for being silenced by promoter methylation.

Table S4 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S4. Significantly enriched functional groups for 174 hypermethylated genes in Ingeniuty Pathway Analysis

Table S4 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S4. Significantly enriched functional groups for 174 hypermethylated genes in Ingeniuty Pathway Analysis

Table S2 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S2. Basic sequencing statistics of NK samples

Table S1 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Table S1. Pathological characteristics and available data of NK-cell lymphoma cases (A) and NK cell lines (B).

Data from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Purpose: To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL).Experimental Design: Promoter methylation was analyzed with global and locus-s…

Data from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Purpose: To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL).Experimental Design: Promoter methylation was analyzed with global and locus-s…

Supplemental Figures 1-12 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Supplemental Figures 1-12. Fig.1: The distribution of mappable HpaII sites(MSCC cut sites) and the distribution of MSCC reads in normal NK cells; Fig.2: Mean log2 cut counts per site for promoters and bodies of genes with differing normal …

Supplemental Figures 1-12 from Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2023

Supplemental Figures 1-12. Fig.1: The distribution of mappable HpaII sites(MSCC cut sites) and the distribution of MSCC reads in normal NK cells; Fig.2: Mean log2 cut counts per site for promoters and bodies of genes with differing normal …

Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tumor-Infiltrating Immunocytes in Mantle Cell Lymphoma Open

Esra Esmeray Sönmez, Tevfik Hatipoğlu, Deniz Kurşun, Xiaozhou Hu, Burcu Akman , et al. · 2022

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) subtype characterized by overexpression of CCND1 and SOX11 genes. It is generally associated with clinically poor outcomes despite recent improvements in therape…

THERAPEUTIC IMPLICATIONS OF TARGETED SEQUENCING AND miRNA-SEQ OF B CELL LYMPHOMAS Open

Esra Esmeray Sönmez, Tevfik Hatipoğlu, Xiaozhou Hu, Hongling Yuan, Ayça Erşen Danyeli , et al. · 2022

Objective: Next-generation sequencing (NGS)-based approaches facilitated the identification of genomic and transcriptomic alterations associated withthe development of B-cell lymphomas. Identification of these aberrancies during diagnosis …

Plasma Concentrations and Cancer-Associated Mutations in Cell-Free Circulating DNA of Treatment-Naive Follicular Lymphoma for Improved Non-Invasive Diagnosis and Prognosis Open

Tevfik Hatipoğlu, Esra Esmeray Sönmez, Xiaozhou Hu, Hongling Yuan, Ayça Erşen Danyeli , et al. · 2022

Follicular lymphoma (FL) is the second most frequent non-Hodgkin lymphoma accounting for 10-20% of all lymphomas in western countries. As a clinically heterogeneous cancer, FL occasionally undergoes histological transformation to more aggr…

PRDM1 decreases sensitivity of human NK cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA) Open

Burcu Akman, Xiaozhou Hu, Xuxiang Liu, Tevfik Hatipoğlu, Hua You , et al. · 2020

IL2 receptor signaling is crucial for human NK cell activation and gain of effector functions. The molecular mechanisms involved in termination of IL2 activation are largely unknown in human NK cells. PR/SET domain 1 was previously reporte…

378 Enhanced AQP3 induced by short-term of UVA irradiation prevents skin photoaging through activating autophagy by interacting with DEDD and Beclin1 Open

F. Liu, Xiaozhou Hu, Lin Zhou, Jennifer Long, Siyu Yan , et al. · 2019

Table of Contents Open

Charles A. Parkos, Corneliu Sima, Guy M. Aboodi, Flavia Lakschevitz, Chunxiang Sun , et al. · 2016

Diagnostic and Biological Significance of KIR Expression Profile Determined by RNA-Seq in Natural Killer/T-Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Qiang Gong, Bei Jiang, Adam Cornish , et al. · 2016

Lack of Evidence that HACE1 Is Not a Tumor Suppressor Gene in NKTCL Open

Can Küçük, Xiaozhou Hu, Timothy W. McKeithan, Wing C. Chan · 2015

Global Promoter Methylation Analysis Reveals Novel Candidate Tumor Suppressor Genes in Natural Killer Cell Lymphoma Open

Can Küçük, Xiaozhou Hu, Bei Jiang, David Klinkebiel, Huimin Geng , et al. · 2015

Purpose: To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL). Experimental Design: Promoter methylation was analyzed with global and locus-specific methy…

Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells Open

Can Küçük, Bei Jiang, Xiaozhou Hu, Wenyan Zhang, John Chan , et al. · 2015

Generation of a genetically engineered aggressive Nk-Cell leukemia cell line with stable IL2 expression Open

Can Küçük, Xiaozhou Hu, WingC Chan · 2015

Introduction: Aggressive NK-cell leukemia (ANKL) is a highly aggressive disease with extremely poor prognosis. A few malignant NK cell lines reflecting ANKL biology have been generated; however, these NK cell lines require the inclusion of…

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