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View article: The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein
The deubiquitinase USP24 suppresses ferroptosis in triple-negative breast cancer by stabilizing DHODH protein Open
Triple-negative breast cancer (TNBC) is an aggressive subtype of invasive breast cancer characterized by limited treatment options and a poor prognosis. While ferroptosis, an iron-dependent form of regulated cell death, plays a role in tum…
View article: Missense variants in GABA<sub>A</sub>receptor beta2 subunit disrupt receptor biogenesis and cause loss of function
Missense variants in GABA<sub>A</sub>receptor beta2 subunit disrupt receptor biogenesis and cause loss of function Open
Gamma-aminobutyric acid type A receptors (GABA A Rs) are the major inhibitory neurotransmitter-gated channel in the mammalian central nervous system. GABA A Rs function as heteropentamers, typically composed of two α1, two β2, and one γ2 s…
View article: Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9–mediated inhibition of N6-methyladenosine demethylase FTO
Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9–mediated inhibition of N6-methyladenosine demethylase FTO Open
Porcine reproductive and respiratory syndrome virus (PRRSV), a highly infectious virus, causes severe losses in the swine industry by regulating the inflammatory response, inducing tissue damage, suppressing the innate immune response, and…
View article: Nucleocapsid Protein residues 35, 36, and 113 are critical sites in up- regulating the Interleukin-8 Production via C/EBPα pathway by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
Nucleocapsid Protein residues 35, 36, and 113 are critical sites in up- regulating the Interleukin-8 Production via C/EBPα pathway by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Open
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious and pathogenic agent that causes considerable economic damage in the swine industry. It regulates the inflammatory response, triggers inflammation-induced t…
View article: Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83
Porcine Reproductive and Respiratory Syndrome Virus Modulates the Switch of Macrophage Polarization from M1 to M2 by Upregulating MoDC-Released sCD83 Open
Porcine reproductive and respiratory syndrome virus (PRRSV), the most economically important infectious disease of pigs, elicits poor innate and adaptive immune responses. Soluble CD83 (sCD83), a secretion from various immune cell populati…
View article: Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study
Radical surgery for stage IB2/IIA2 cervical cancer: A large retrospective study Open
Background We aimed to evaluate survival, complications, and prognostic factors in patients with IB2/IIA2 (FIGO 2009, bulky early-stage) cervical cancer (CC) who were primarily treated with radical surgery (RS). Methods From January 2011 t…
View article: Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1 Open
Tumor necrosis factor-α (TNF) is described as a main regulator of cell survival and apoptosis in multiple types of cells, including hepatocytes. Dysregulation in TNF-induced apoptosis is associated with many autoimmune diseases and various…
View article: Viral suppressors from members of the family Closteroviridae combating antiviral RNA silencing: a tale of a sophisticated arms race in host-pathogen interactions
Viral suppressors from members of the family Closteroviridae combating antiviral RNA silencing: a tale of a sophisticated arms race in host-pathogen interactions Open
RNA silencing is an evolutionarily homology-based gene inactivation mechanism and plays critical roles in plant immune responses to acute or chronic virus infections, which often pose serious threats to agricultural productions. Plant anti…
View article: SET DOMAIN GROUP 721 protein functions in saline–alkaline stress tolerance in the model rice variety Kitaake
SET DOMAIN GROUP 721 protein functions in saline–alkaline stress tolerance in the model rice variety Kitaake Open
To isolate the genetic locus responsible for saline–alkaline stress tolerance, we developed a high‐throughput activation tagging‐based T‐DNA insertion mutagenesis method using the model rice ( Oryza sativa L.) variety Kitaake. One of the a…
View article: Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum‒organelle interactions
Three-dimensional ATUM-SEM reconstruction and analysis of hepatic endoplasmic reticulum‒organelle interactions Open
The endoplasmic reticulum (ER) is a contiguous and complicated membrane network in eukaryotic cells, and membrane contact sites (MCSs) between the ER and other organelles perform vital cellular functions, including lipid homeostasis, metab…
View article: Discriminating symbiosis and immunity signals by receptor competition in rice
Discriminating symbiosis and immunity signals by receptor competition in rice Open
Significance Plant adaptation in nature relies on the appropriate response to symbiotic and pathogenic microbes. Chitin is an important component of the mycorrhizal fungi cell wall and a major microbe-associated molecular pattern (MAMP), w…
View article: Genome-Wide Identification, Characterization, and Expression Analyses of P-Type ATPase Superfamily Genes in Soybean
Genome-Wide Identification, Characterization, and Expression Analyses of P-Type ATPase Superfamily Genes in Soybean Open
P-type ATPases are transmembrane pumps of cations and phospholipids. They are energized by hydrolysis of ATP and play important roles in a wide range of fundamental cellular and physiological processes during plant growth and development. …
View article: Prophylactic antibiotic treatment with TMP-SMX decreased the incidence of interstitial pneumonia in patients with B-cell lymphoma on chemotherapy
Prophylactic antibiotic treatment with TMP-SMX decreased the incidence of interstitial pneumonia in patients with B-cell lymphoma on chemotherapy Open
Background Several studies have reported the incidence of interstitial pneumonia (IP) among patients with non-Hodgkin lymphoma (NHL) that are undergoing combination chemotherapy plus rituximab; however, the effective prophylactic treatment…
View article: Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy
Stepwise targeting and responsive lipid-coated nanoparticles for enhanced tumor cell sensitivity and hepatocellular carcinoma therapy Open
Rationale: Antitumor drug delivery faces multiple barriers that require consecutively achieving tumor targeting, selective cellular uptake and sufficient intracellular drug dosage. Methods: Herein, we designed smart nanoparticles (GPDC-MSN…
View article: Microbial Community Analyses Associated with Nine Varieties of Wine Grape Carposphere Based on High-Throughput Sequencing
Microbial Community Analyses Associated with Nine Varieties of Wine Grape Carposphere Based on High-Throughput Sequencing Open
Understanding the composition of microbials on the grape carposphere may provide direct guidance for the wine brewing. In this work, 16S rRNA and ITS (Internal Transcribed Spacer) fungal amplicon sequencing were performed to investigate th…
View article: Two New Lignans from Lycopodium japonicum Thunb.
Two New Lignans from Lycopodium japonicum Thunb. Open
Two new lignans, named lycojaponicumoside A (1) and B (2), together with four known compounds (3˗6) were isolated from the n-BuOH extract of Lycopodium japonicum.Their structures were elucidated on the basis of extensive spectroscopic meth…
View article: Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease
Bcl-3 is a novel biomarker of renal fibrosis in chronic kidney disease Open
Progressive renal fibrosis in chronic kidney disease (CKD) greatly contributes to end-stage renal failure and is associated with high mortality. The identification of renal fibrosis biomarkers for the diagnosis and the monitoring of diseas…
View article: RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis
RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis Open
Dysfunction of nuclear factor- κ B (NF- κ B) signaling has been causally associated with numerous human malignancies. Although the NF- κ B family of genes has been implicated in endometrial carcinogenesis, information regarding the involve…
View article: Organic nitrogen uptake is a significant contributor to nitrogen economy of subtropical epiphytic bryophytes
Organic nitrogen uptake is a significant contributor to nitrogen economy of subtropical epiphytic bryophytes Open
Without any root contact with the soil, epiphytic bryophytes must experience and explore poor, patchy, and heterogeneous habitats; while, the nitrogen (N) uptake and use strategies of these organisms remain uncharacterized, which obscures …