Xiawei Li
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View article: Association study between intestinal microbiota dysbiosis in inflammatory bowel disease and the global disease burden growth trend
Association study between intestinal microbiota dysbiosis in inflammatory bowel disease and the global disease burden growth trend Open
Background Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a group of chronic intestinal inflammatory diseases. Its incidence and prevalence have been on the rise globally, imposing a heavy burden on …
View article: Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis
Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis Open
Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for e…
View article: Surgical Resection Enhances Survival in Patients With Liver Metastases From Gastric Cancer: A Population‐Based, Case‐Control Study
Surgical Resection Enhances Survival in Patients With Liver Metastases From Gastric Cancer: A Population‐Based, Case‐Control Study Open
Background and Aims Gastric cancer with liver metastases (GCLM) is a challenging condition that significantly reduces long‐term survival rates, but recent advancements in surgical techniques have shown promise. This study aims to comprehen…
View article: Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5
Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5 Open
A rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-o…
View article: Predicting Pancreatic Cancer in New‐Onset Diabetes Cohort Using a Novel Model With Integrated Clinical and Genetic Indicators: A Large‐Scale Prospective Cohort Study
Predicting Pancreatic Cancer in New‐Onset Diabetes Cohort Using a Novel Model With Integrated Clinical and Genetic Indicators: A Large‐Scale Prospective Cohort Study Open
Introduction Individuals who develop new‐onset diabetes have been identified as a high‐risk cohort for pancreatic cancer (PC), exhibiting an incidence rate nearly 8 times higher than the general population. Hence, the targeted screening of…
View article: Multi-Modality Affinity Inference for Weakly Supervised 3D Semantic Segmentation
Multi-Modality Affinity Inference for Weakly Supervised 3D Semantic Segmentation Open
3D point cloud semantic segmentation has a wide range of applications. Recently, weakly supervised point cloud segmentation methods have been proposed, aiming to alleviate the expensive and laborious manual annotation process by leveraging…
View article: Diffusion Model is Secretly a Training-free Open Vocabulary Semantic Segmenter
Diffusion Model is Secretly a Training-free Open Vocabulary Semantic Segmenter Open
The pre-trained text-image discriminative models, such as CLIP, has been explored for open-vocabulary semantic segmentation with unsatisfactory results due to the loss of crucial localization information and awareness of object shapes. Rec…
View article: Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes
Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes Open
A rise in blood glucose is the early warning signs of underlying pancreatic cancer (PC), which could be the externalization of genetic events in PC progression. But there is still a vacancy in the field of mechanism research on pancreatic …
View article: Does Surgical Resection Improve the Survival of Patients with Gastric Cancer Liver Metastases? A Population-Based, Propensity Score–Adjusted Analysis
Does Surgical Resection Improve the Survival of Patients with Gastric Cancer Liver Metastases? A Population-Based, Propensity Score–Adjusted Analysis Open
Purpose The use of surgery in the management of patients with gastric cancer liver metastases (GCLM) has been debatable. We aimed to assess whether surgical resection is associated with improved patient survival. Methods Patients with GCLM…
View article: Impact of radiation therapy and alpha-fetoprotein level on survival outcomes for patients with hepatocellular carcinoma: a population-based study
Impact of radiation therapy and alpha-fetoprotein level on survival outcomes for patients with hepatocellular carcinoma: a population-based study Open
Background The use of radiation therapy (RT) in hepatocellular carcinoma (HCC) remains a matter for debate. Recently published research indicate that advanced RT techniques may improve survival in patients with HCC. This study aimed to eva…
View article: Prediction of risk and overall survival of pancreatic cancer from blood soluble immune checkpoint-related proteins
Prediction of risk and overall survival of pancreatic cancer from blood soluble immune checkpoint-related proteins Open
Background Immune checkpoint inhibition holds promise as a novel treatment for pancreatic ductal adenocarcinoma (PDAC). The clinical significance of soluble immune checkpoint (ICK) related proteins have not yet fully explored in PDAC. Meth…
View article: Pathologic complete response of hepatoid adenocarcinoma of the stomach after chemo-immunotherapy: A rare case report and literature review
Pathologic complete response of hepatoid adenocarcinoma of the stomach after chemo-immunotherapy: A rare case report and literature review Open
Background Hepatoid adenocarcinoma of the stomach (HAS) is a highly malignant subtype of gastric carcinoma with specific clinicopathological features and extremely poor prognosis. We present an exceedingly rare case of complete response af…
View article: Efficacy and safety of FOLFIRINOX as second-line chemotherapy for advanced pancreatic cancer after gemcitabine-based therapy: A systematic review and meta-analysis
Efficacy and safety of FOLFIRINOX as second-line chemotherapy for advanced pancreatic cancer after gemcitabine-based therapy: A systematic review and meta-analysis Open
Objective To undertake a meta-analysis of the treatment effects of different second-line chemotherapy regimens compared with FOLFIRINOX (FOL [folinic acid], F [fluorouracil], IRIN [irinotecan], OX [oxaliplatin]) after failure of gemcitabin…
View article: The Effect of Indoor Daylight Levels on Hospital Costs and Length of Stay of Patients Admitted to General Surgery
The Effect of Indoor Daylight Levels on Hospital Costs and Length of Stay of Patients Admitted to General Surgery Open
Background Indoor daylight levels can directly affect the physical and psychological state of people. However, the effect of indoor daylight levels on the clinical recovery process of the patient remains controversial. This study was to ev…
View article: Multi-institutional development and external validation of machine learning-based models to predict relapse risk of pancreatic ductal adenocarcinoma after radical resection
Multi-institutional development and external validation of machine learning-based models to predict relapse risk of pancreatic ductal adenocarcinoma after radical resection Open
Background Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC) and the survival of patients after radical resection is closely related to relapse. We aimed to develop models to predict …
View article: Whether early stage pancreatic ductal adenocarcinoma patients could benefit from the post-operation chemotherapy regimens: a SEER-based propensity score matching study
Whether early stage pancreatic ductal adenocarcinoma patients could benefit from the post-operation chemotherapy regimens: a SEER-based propensity score matching study Open
To investigate whether chemotherapy could prolong the postoperative survival time in patients with early stages pancreatic ductal adenocarcinoma (PDAC). A total of 5280 stage ⅠA -ⅡB PDAC patients diagnosed from 2010 to 2015 were selected f…
View article: Identification of Serum Circulating MicroRNAs as Novel Diagnostic Biomarkers of Gastric Cancer
Identification of Serum Circulating MicroRNAs as Novel Diagnostic Biomarkers of Gastric Cancer Open
Gastric cancer (GC) is one of the leading causes of cancer-associated deaths worldwide. Due to the lack of typical symptoms and effective biomarkers for non-invasive screening, most patients develop advanced-stage GC by the time of diagnos…
View article: Does Indoor Daylight Level Affect Hospital Costs and Length of Stay of Patients? A Retrospective Cohort Study
Does Indoor Daylight Level Affect Hospital Costs and Length of Stay of Patients? A Retrospective Cohort Study Open
BackgroundIndoor daylight levels can directly affect people’s physical and psychological state. However, the effect of indoor daylight levels on patient’s clinical recovery process remains controversial. To evaluate the effect of indoor da…
View article: The Effect of Indoor Daylight Levels on Patients Admitted to General Surgery
The Effect of Indoor Daylight Levels on Patients Admitted to General Surgery Open
BackgroundIndoor daylight levels can directly affect people’s physical and psychological state. However, the effect of indoor daylight levels on patient’s clinical recovery process remains controversial.AimTo evaluate the effect of indoor …
View article: Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers
Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers Open
Mining cancer-omics databases deepens our understanding of cancer biology and can lead to potential breakthroughs in cancer treatment. Here, we propose an integrative analytical approach to reveal across-cancer expression patterns and iden…
View article: Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice
Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice Open
Thymocyte-expressed, positive selection-associated 1 (Tespa1) plays an important role in both T cell receptor (TCR)-driven thymocyte development and in the FcεRI-mediated activation of mast cells. Herein, we show that lack of Tespa1 does n…
View article: SNX10 promotes phagosome maturation in macrophages and protects mice against<i>Listeria monocytogenes</i>infection
SNX10 promotes phagosome maturation in macrophages and protects mice against<i>Listeria monocytogenes</i>infection Open
Listeria monocytogenes (L. monocytogenes), which is a facultative intracellular bacterial pathogen that causes listeriosis, is widely used to study the mammalian immune response to infection. After phagocytosis by professional phagocytes, …
View article: Maternal dyslipidemia during pregnancy may increase the risk of preterm birth: A meta-analysis
Maternal dyslipidemia during pregnancy may increase the risk of preterm birth: A meta-analysis Open
Epidemiological studies have reported an inconsistent relationship between maternal lipid levels and preterm birth (PTB). We performed this meta-analysis to evaluate the association between maternal dyslipidemia and PTB. Overall, three nes…