Xi‐Bei Chen
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View article: DGAT2 reduction and lipid dysregulation drive psoriasis development in keratinocyte-specific SPRY1-deficient mice
DGAT2 reduction and lipid dysregulation drive psoriasis development in keratinocyte-specific SPRY1-deficient mice Open
Psoriasis is a chronic autoimmune skin disease characterized by abnormal keratinocyte proliferation and immune dysregulation. Altered lipid metabolism has been implicated in its pathogenesis, but the underlying mechanisms remain unclear. I…
View article: CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling Open
Psoriatic arthritis (PsA) is a multifaceted, chronic inflammatory disease affecting the skin, joints, and entheses, and it is a major comorbidity of psoriasis. Most patients with PsA present with psoriasis before articular involvement; how…
View article: Cell atlas of human psoriasis and epidermal specific Ube2l3 deficiency mouse highlighting CXCL16/CXCR6 orchestrating the development of psoriasis
Cell atlas of human psoriasis and epidermal specific Ube2l3 deficiency mouse highlighting CXCL16/CXCR6 orchestrating the development of psoriasis Open
Psoriasis is a chronic, complex immune-mediated inflammatory disorder with cutaneous and systemic manifestations in which keratinocytes, dendritic cells and T cells have central roles. UBE2L3 may be a protective biomarker that regulates th…
View article: Gradually increasing the dosing interval of Secukinumab for moderate to severe plaque psoriasis: A single‐center, uncontrolled, prospective study in 36 weeks
Gradually increasing the dosing interval of Secukinumab for moderate to severe plaque psoriasis: A single‐center, uncontrolled, prospective study in 36 weeks Open
Secukinumab is a recombinant, fully human monoclonal anti-IL-17A antibody approved to treat moderate-to-severe psoriasis and psoriatic arthritis. Its effectiveness and safety have been confirmed, but a gradual increase in the secukinumab d…
View article: The role of Sprouty1 in the proliferation, differentiation and apoptosis of epidermal keratinocytes
The role of Sprouty1 in the proliferation, differentiation and apoptosis of epidermal keratinocytes Open
Objectives Sprouty ( SPRY ) 1 is one of the SPRY proteins that inhibits signalling from various growth factors pathways and has also been known as a tumour suppressor in various malignancies. However, no study elucidates the role of SPRY 1…
View article: K24 overexpression in NHEK induces autophagy.
K24 overexpression in NHEK induces autophagy. Open
(A, B) NHEK overexpressing K24 were fixed for TEM analysis comparing with vector control group. The right views (Scale bar = 0.2μm) were the magnification of the region with a black box in the left views (Scale bar = 0.5μm). k: cytokeratin…
View article: Role of keratin 24 in human epidermal keratinocytes
Role of keratin 24 in human epidermal keratinocytes Open
Keratin 24 (K24) is a new kind of keratin genes, which encodes a novel keratin protein, K24 that bears high similarity to the type I keratins and displays a unique expression profile. However, the role of K24 is incompletely understood. In…
View article: Analysis of epithelial–mesenchymal transition markers in psoriatic epidermal keratinocytes
Analysis of epithelial–mesenchymal transition markers in psoriatic epidermal keratinocytes Open
Psoriasis is similar to endpoints of epithelial–mesenchymal transition (EMT), a process of epithelial cells transformed into fibroblast-like cells. The molecular epithelial and mesenchymal markers were analysed in psoriatic keratinocytes. …
View article: Docetaxel‐induced scleroderma: a case report and its role in the production of extracellular matrix
Docetaxel‐induced scleroderma: a case report and its role in the production of extracellular matrix Open
Dear Editor, A 52-year-old woman was admitted to our department because of a progressive thickening and tightening of the skin for 2 months. Seven months ago, she was diagnosed as having infiltrating ductal carcinoma on the left breast. Ei…