Xichen Zhang
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View article: β-Giardin as an Immunomagnetic Enrichment Target for Multi-Host Detection of Giardia duodenalis Cysts
β-Giardin as an Immunomagnetic Enrichment Target for Multi-Host Detection of Giardia duodenalis Cysts Open
Giardiasis is a globally prevalent waterborne zoonosis. Rapid enrichment and detection technologies for this disease are essential. Cyst outer wall proteins are ideal targets for the enrichment and detection of cysts in the environment, bu…
View article: JRN-Geo: A Joint Perception Network based on RGB and Normal images for Cross-view Geo-localization
JRN-Geo: A Joint Perception Network based on RGB and Normal images for Cross-view Geo-localization Open
Cross-view geo-localization plays a critical role in Unmanned Aerial Vehicle (UAV) localization and navigation. However, significant challenges arise from the drastic viewpoint differences and appearance variations between images. Existing…
View article: Pentatrichomonas hominis induces extracellular traps formation of macrophages via the TLR2/NADPH/PAD4 pathway
Pentatrichomonas hominis induces extracellular traps formation of macrophages via the TLR2/NADPH/PAD4 pathway Open
Background Pentatrichomonas hominis ( P. hominis ) is a newly identified pathogenic zoonotic protozoan belonging to the Trichomonadidae family. P. hominis mainly parasitizes the cecum and colon of humans and other mammals, and it can cause…
View article: MedAgentBoard: Benchmarking Multi-Agent Collaboration with Conventional Methods for Diverse Medical Tasks
MedAgentBoard: Benchmarking Multi-Agent Collaboration with Conventional Methods for Diverse Medical Tasks Open
The rapid advancement of Large Language Models (LLMs) has stimulated interest in multi-agent collaboration for addressing complex medical tasks. However, the practical advantages of multi-agent collaboration approaches remain insufficientl…
View article: Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1
Molecular interactions of Toxoplasma gondii dense granule 23 (GRA23) with host proteins PEX3 and TRAP1 Open
Background Toxoplasma gondii , an obligate intracellular protozoan, utilizes dense granule proteins to modulate host cell processes. Dense granule protein 23 (GRA23) facilitates molecular trafficking between the parasitophorous vacuole and…
View article: HDAC7 is a potential therapeutic target in acute erythroid leukemia
HDAC7 is a potential therapeutic target in acute erythroid leukemia Open
Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia with a poor prognosis. In this study, we established a novel murine AEL model with Trp53 depletion and ERG overexpression. ERG overexpression in Trp53 -deficient mouse…
View article: Research on the Current Situation and Calculation Method of Carbon Emissions Assessment for Building Curtain Walls
Research on the Current Situation and Calculation Method of Carbon Emissions Assessment for Building Curtain Walls Open
Curtain wall systems stand out as a pivotal domain within the construction sector’s endeavors towards energy efficiency and carbon mitigation. To refine the evaluation framework for carbon emissions within this industry, this paper explore…
View article: HDAC7 is a specific therapeutic target in Acute Erythroid Leukemia
HDAC7 is a specific therapeutic target in Acute Erythroid Leukemia Open
Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia with a poor prognosis. In this study, we established a novel murine AEL model with Trp53 depletion and ERG overexpression. ERG overexpression in Trp53-deficient mouse …
View article: Determination of cAMP and protein content in dormant chlamydospore and non-dormant chlamydospore of Duddingtonia flagrans
Determination of cAMP and protein content in dormant chlamydospore and non-dormant chlamydospore of Duddingtonia flagrans Open
Duddingtonia flagrans, a nematode-eating fungus, is an effective component of animal parasitic nematode biocontrol agents. In the dried formulation, the majority of spores are in an endogenous dormant state. This study focuses on dormant c…
View article: Development of an LFD-RPA Assay for Rapid Detection of Pentatrichomonas hominis Infection in Dogs
Development of an LFD-RPA Assay for Rapid Detection of Pentatrichomonas hominis Infection in Dogs Open
Pentatrichomonas hominis is a trichomonad protozoan that infects the cecum and colon of humans and other mammals. It is a zoonotic pathogen that causes diarrhea in both animals and humans. As companion animals, dogs infected with P. homini…
View article: Application of Research-Based Quality Control Circle in Setting a New Management Model and Complete Standardized Care for Continuous Bladder Irrigation After TURP
Application of Research-Based Quality Control Circle in Setting a New Management Model and Complete Standardized Care for Continuous Bladder Irrigation After TURP Open
Objective: To explore the application of research-based quality control circle in setting a new standardized nursing management model for continuous bladder irrigation after transurethral resection of prostate (TURP) surgery, and to provid…
View article: Development of Nested Polymerase Chain Reaction with Novel Specific Primers for Detection of Tritrichomonas muris Infection in Laboratory Mice
Development of Nested Polymerase Chain Reaction with Novel Specific Primers for Detection of Tritrichomonas muris Infection in Laboratory Mice Open
A variety of rodent ceca are parasitized by Tritrichomonas muris (T. muris), a flagellated protozoan. To date, there are no ideal methods for the detection of T. muris infections in laboratory mice; thus, new molecular methodologies for it…
View article: PET imaging with [68Ga]-labeled TGFβ-targeting peptide in a mouse PANC-1 tumor model
PET imaging with [68Ga]-labeled TGFβ-targeting peptide in a mouse PANC-1 tumor model Open
Purpose Transforming growth factor β (TGFβ) is upregulated in many types of tumors and plays important roles in tumor microenvironment construction, immune escape, invasion, and metastasis. The therapeutic effect of antibodies and nuclide-…
View article: Microstructure characterization of different types of chlamydospores in <i>Arthrobotrys flagrans</i>
Microstructure characterization of different types of chlamydospores in <i>Arthrobotrys flagrans</i> Open
The morphological and structural differences of different types of chlamydospore of Arthrobotrys flagrans , a nematophagous fungus, were studied under light microscope and electron microscope to provide a reference for the biological contr…
View article: Rapid, sensitive, and visual detection of Clonorchis sinensis with an RPA-CRISPR/Cas12a-based dual readout portable platform
Rapid, sensitive, and visual detection of Clonorchis sinensis with an RPA-CRISPR/Cas12a-based dual readout portable platform Open
Clonorchis sinensis is a food-borne parasite that parasitizes the liver and bile ducts of humans and many animals. This parasite exerts a high burden due to diverse hepatobiliary morbidities (e.g., cholangitis, cholecystitis, cholelithiasi…
View article: A potential role for Giardia chaperone protein GdDnaJ in regulating Giardia proliferation and Giardiavirus replication
A potential role for Giardia chaperone protein GdDnaJ in regulating Giardia proliferation and Giardiavirus replication Open
Background Giardia duodenalis (referred to as Giardia ) is a flagellated binucleate protozoan parasite, which causes one of the most common diarrheal diseases, giardiasis, worldwide. Giardia can be infected by Giardiavirus (GLV), a small e…
View article: TLR3 activation by Clonorchis sinensis infection alleviates the fluke-induced liver fibrosis
TLR3 activation by Clonorchis sinensis infection alleviates the fluke-induced liver fibrosis Open
Clonorchis sinensis is a zoonotic parasite associated with liver fibrosis and cholangiocarcinoma development. The role of toll-like receptors (TLRs) in C . sinensis infection has not yet been fully elucidated. Here, the TLR3 signaling path…
View article: Immunogenicity and efficacy of serogroup A and D bacterins against Pasteurella multocida in mice
Immunogenicity and efficacy of serogroup A and D bacterins against Pasteurella multocida in mice Open
Introduction Pasteurella multocida is a widespread respiratory pathogen in pigs, causing swine pneumonia and atrophic rhinitis, and the capsular serogroups A and D are the main epidemic serogroups in infected animals. This study investigat…
View article: Clonorchis sinensis aggravates biliary fibrosis through promoting IL-6 production via toll-like receptor 2-mediated AKT and p38 signal pathways
Clonorchis sinensis aggravates biliary fibrosis through promoting IL-6 production via toll-like receptor 2-mediated AKT and p38 signal pathways Open
Clonorchis sinensis is an important food-borne zoonotic parasite which has been linked to biliary fibrosis and cholangiocarcinoma. However, the details of the pathogenesis of C . sinensis were unclear. To explore the role and regulatory me…
View article: Multiple Regulations of Parasitic Protozoan Viruses: A Double-Edged Sword for Protozoa
Multiple Regulations of Parasitic Protozoan Viruses: A Double-Edged Sword for Protozoa Open
PPVs-based regulation of parasitic protozoa can provide a theoretical basis and direction for PPD prevention and control, although PPVs and PPV regulatory mechanisms remain unclear. In this review, we investigated the differences between P…
View article: Cryptosporidium parvum regulates HCT-8 cell autophagy to facilitate survival via inhibiting miR-26a and promoting miR-30a expression
Cryptosporidium parvum regulates HCT-8 cell autophagy to facilitate survival via inhibiting miR-26a and promoting miR-30a expression Open
Background Cryptosporidium parvum is an important zoonotic parasite, which not only causes economic losses in animal husbandry but also harms human health. Due to the lack of effective measures for prevention and treatment, it is important…
View article: Evaluation of Protective Immune Responses Induced in BALB/c Mice and Goats by the Neospora caninum Surface SRS Proteins and Interleukin-18
Evaluation of Protective Immune Responses Induced in BALB/c Mice and Goats by the Neospora caninum Surface SRS Proteins and Interleukin-18 Open
Neosporosis is caused by Neospora caninum (N. caninum), which mainly infects cattle and goats and severely threatens the animal industry. In this study, the inhibitory effects of polyclonal antiserum anti-NcSRS17, NcSRS2 and NcSRS52 were e…
View article: Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection
Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection Open
Pentatrichomonas hominis is a parasitic trichomonads protozoa that parasitizes in the colon and cecum of humans and other animals. Our previous studies have demonstrated that infection with P. hominis is associated with the incidence of co…