Xichen Wan
YOU?
Author Swipe
View article: Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease
Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease Open
SMS2 promotes DED progression by driving oxidative stress-induced lipid dysregulation and NF-κB activation. SMS2 deficiency attenuates ocular surface damage, restores tear function, and suppresses inflammation, identifying SMS2 as a therap…
View article: Human meibomian gland organoids to study epithelial homeostasis and dysfunction
Human meibomian gland organoids to study epithelial homeostasis and dysfunction Open
Meibomian glands (MGs) are holocrine glands that secrete lipids to maintain the homeostasis of ocular surface, and their dysfunction leads to dry eye disease. Herein, we established long-term 3D organoid culture for murine and human MGs, w…
View article: Identification of Matrix Metalloproteinase 3 as a Potential Biomarker for Dry Eye Disease
Identification of Matrix Metalloproteinase 3 as a Potential Biomarker for Dry Eye Disease Open
Tear MMP-3 levels were closely associated with the CFS score of patients with DED, and the inhibition of MMP-3 alleviated the DED-related phenotype in vitro, thereby suggesting that MMP-3 is a potential biomarker for DED diagnosis and coul…
View article: Clinical characteristics of dry eye patients with thyroid disorders: a cross-sectional study
Clinical characteristics of dry eye patients with thyroid disorders: a cross-sectional study Open
Shorter NIBUT and higher MG dropout ratio correlated with abnormally elevated levels of Anti-TPO and Anti-Tg in DED patients. A combination of NIBUT and MG dropout assessment may have diagnostic potential as a predictive biomarker of possi…
View article: Causal Associations of Brain Imaging-Derived Phenotypes and Intracranial Aneurysm: A Bidirectional Mendelian Randomization Study
Causal Associations of Brain Imaging-Derived Phenotypes and Intracranial Aneurysm: A Bidirectional Mendelian Randomization Study Open
The findings indicate that these IDPs play a crucial role in the etiology of these IAs and highlight the importance of understanding the mechanisms through which they exert their effects.
View article: RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway
RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway Open
RSPO3 promotes the proliferation and self-renewal of LESCs through a WNT/β-catenin-independent signaling pathway which might have translational significance in the treatment of corneal epithelium injury and limbal stem cell deficiency.
View article: Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy Open
Dry eye disease (DED) is a prevalent and intractable ocular disease induced by a variety of causes. Elevated sphingomyelin (SM) levels and pro-inflammatory cytokines were detected on the ocular surface of DED patients, particularly in the …
View article: Establishment of human corneal epithelial organoids for ex vivo modelling dry eye disease
Establishment of human corneal epithelial organoids for ex vivo modelling dry eye disease Open
Dry eye disease (DED) is a growing public health concern affecting millions of people worldwide and causing ocular discomfort and visual disturbance. Developing its therapeutic drugs based on animal models suffer from interspecies differen…
View article: The Effect of Vidian Neurectomy on the Ocular Surface – The Primary Results from a Six-Month Pilot Study
The Effect of Vidian Neurectomy on the Ocular Surface – The Primary Results from a Six-Month Pilot Study Open
In this 6-month prospective pilot study, decreased tearing was observed after VN, but this decrease did not increase the possibility of dry eyes.
View article: Cross-regulation between SOX9 and the canonical Wnt signalling pathway in stem cells
Cross-regulation between SOX9 and the canonical Wnt signalling pathway in stem cells Open
SOX9, a member of the SRY-related HMG-box transcription factors, has been reported to critically regulate fetal development and stem cell homeostasis. Wnt signalling is a highly conserved signalling pathway that controls stem cell fate dec…
View article: Prognostic model for aneurysmal subarachnoid hemorrhage patients requiring mechanical ventilation
Prognostic model for aneurysmal subarachnoid hemorrhage patients requiring mechanical ventilation Open
Objective Aneurysmal subarachnoid hemorrhage (aSAH) is a major cause of death and disability worldwide and imposes serious burdens on society and individuals. However, predicting the long‐term outcomes in aSAH patients requiring mechanical…
View article: <scp>WNT16b</scp> promotes the proliferation and <scp>self‐renewal</scp> of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/<scp>NFATC2</scp> pathway
<span>WNT16b</span> promotes the proliferation and <span>self‐renewal</span> of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/<span>NFATC2</span> pathway Open
Our previous finding revealed that WNT16b promoted the proliferation of human limbal epithelial stem cells (hLESCs) through a β‐catenin independent pathway. Here, we aimed to explore its underlying molecular mechanism and evaluate its pote…
View article: Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial
Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial Open
Purpose: To evaluate the efficacy and safety of eyelid hygiene using topical 0.01% hypochlorous acid (HOCL) through ultrasonic atomization after 2 weeks in patients with blepharitis. Design: Randomized controlled trial. Methods: Patients w…
View article: Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage Open
Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by dysfunctional inflammatory response. However, no effective therapeutic options have been reported so far. Microglia polarization has been proposed to exert an essen…
View article: WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling
WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling Open
Culture of limbal epithelial cells (LECs) provides the principal source of transplanted limbal stem cells (LESCs) for treatment of limbal-stem-cell deficiency. Optimization of the culture conditions for in-vitro-expanded LECs will help to …
View article: Indications and Surgical Techniques for Repeat Corneal Transplantation in Eastern China: A Twelve-Year Study
Indications and Surgical Techniques for Repeat Corneal Transplantation in Eastern China: A Twelve-Year Study Open
Purpose. To analyze the indications and surgical procedures for repeat keratoplasty in eastern China from 2008 to 2019. Methods. This retrospective descriptive study included 418 eyes of 411 patients who underwent no less than 2 keratoplas…
View article: Trends of Corneal Transplantation in Adults from 2010 to 2019 in East China: A 10-Year Experience
Trends of Corneal Transplantation in Adults from 2010 to 2019 in East China: A 10-Year Experience Open
Introduction: The aim of the study was to provide an overview of trends in the indications and surgical techniques for corneal transplantation in adults in East China from 2010 to 2019. Methods: The medical char…