Xichen Wang
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View article: Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics
Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics Open
Purpose This study aims to utilize genetic instrumental variables - protein quantitative trait loci (pQTL), and through analysis methods such as Mendelian randomization (MR), systematically screen and validate druggable proteins that have …
View article: Traditional Chinese medicine for diabetic peripheral neuropathy: a network meta-analysis
Traditional Chinese medicine for diabetic peripheral neuropathy: a network meta-analysis Open
Background Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus, characterized by high morbidity and significant disability. Traditional Chinese medicine (TCM) has shown potential in relieving symptoms and imp…
View article: How do health shocks affect preventive behaviours? An empirical examination of the mediating role of perceived risk from a longitudinal study in China
How do health shocks affect preventive behaviours? An empirical examination of the mediating role of perceived risk from a longitudinal study in China Open
Objectives Against the heavy burden of non-communicable diseases and the lack of preventive behaviours (PB) in China, health shocks (HSs), as a trigger, provide the teachable moment for promoting PB with a role of perceived risk (PR) in th…
View article: HPGDS as a biomarker for prognosis and immunotherapy in pancreatic cancer
HPGDS as a biomarker for prognosis and immunotherapy in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC), a highly aggressive malignancy with a poor prognosis, is partly attributed to its immunosuppressive microenvironment. Hematopoietic prostaglandin D synthase (HPGDS), a key enzyme in prostaglandin D2…
View article: Modular network analysis of abnormal functional connectivity and disrupted brain topology caused by sleep deprivation and its association with cognitive function
Modular network analysis of abnormal functional connectivity and disrupted brain topology caused by sleep deprivation and its association with cognitive function Open
Our research indicates that SD triggers extensive disturbances in brain networks, along with marked degradation in the topological properties of particular brain regions. Collectively, these alterations significantly diminish cognitive con…
View article: Breeding Strategies of <i>Ginkgo biloba</i> for Medicinal and Ornamental Uses: Progress, Challenges, and Future Perspectives
Breeding Strategies of <i>Ginkgo biloba</i> for Medicinal and Ornamental Uses: Progress, Challenges, and Future Perspectives Open
View article: Current Situation and Analysis of Educational Inequality in China
Current Situation and Analysis of Educational Inequality in China Open
China's educational inequality has long been a concern. The purpose of this paper is to explore the current situation of educational inequality in China and analyze its main manifestations. First of all, the education gap between urban and…
View article: Effect of preoperative inspiratory muscle training combined with preoperative education on postoperative pulmonary complications in high-risk patients with lung cancer: protocol for a randomised controlled trial
Effect of preoperative inspiratory muscle training combined with preoperative education on postoperative pulmonary complications in high-risk patients with lung cancer: protocol for a randomised controlled trial Open
Introduction Preoperative inspiratory muscle training (IMT) is recognised as an important component of the preoperative management of lung cancer, although there is limited evidence for the delivery of a home-based IMT programme combined w…
View article: Visual analysis of research hotspots and trends of external therapies in traditional Chinese medicine for depression
Visual analysis of research hotspots and trends of external therapies in traditional Chinese medicine for depression Open
View article: Effect of Transcranial Alternating Current Stimulation on Ataxia Symptoms of Spinocerebellar Ataxia Type 3: A Randomized Clinical Trial
Effect of Transcranial Alternating Current Stimulation on Ataxia Symptoms of Spinocerebellar Ataxia Type 3: A Randomized Clinical Trial Open
Currently, there are no treatments to alter the natural course of spinocerebellar ataxia type 3 (SCA3). Transcranial alternating current stimulation (tACS) have the sustainable potential to alleviate SCA3. Therefore, we conducted a randomi…
View article: Chewing Gum Is Associated with Better Diet Quality but Not Oral Health Measures in U.S. Adults
Chewing Gum Is Associated with Better Diet Quality but Not Oral Health Measures in U.S. Adults Open
Future observational studies that more accurately capture chewing gum usage are needed, as these analyses have several limitations.
View article: Tea-Infused Foods: Health Benefits and Consumer Appeal
Tea-Infused Foods: Health Benefits and Consumer Appeal Open
View article: Chamomile Tea: An In-Depth Analysis of Its Bioactive Compounds, Therapeutic Applications, and Historical Usage
Chamomile Tea: An In-Depth Analysis of Its Bioactive Compounds, Therapeutic Applications, and Historical Usage Open
View article: Genetic Regulation of Key Aroma Compounds in Different Tea Varieties
Genetic Regulation of Key Aroma Compounds in Different Tea Varieties Open
View article: Structural Variations in Tea Genome and Their Role in Trait Diversity
Structural Variations in Tea Genome and Their Role in Trait Diversity Open
View article: Comprehensive Genomic Analysis of <i>Atractylodes macrocephala</i>: Unveiling Its Medicinal Functions and Genetic Secrets
Comprehensive Genomic Analysis of <i>Atractylodes macrocephala</i>: Unveiling Its Medicinal Functions and Genetic Secrets Open
View article: Transcranial Alternating Current Stimulation for patient in ataxia-ocular apraxia 2: a case report
Transcranial Alternating Current Stimulation for patient in ataxia-ocular apraxia 2: a case report Open
Ataxia-ocular apraxia 2 (AOA2) is a rare neurodegenerative autosomal recessive disorder with no effective treatment. In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated…
View article: Acupuncture and related therapies for tension-type headache: a systematic review and network meta-analysis
Acupuncture and related therapies for tension-type headache: a systematic review and network meta-analysis Open
Background Tension-type headache (TTH) is one of the most common primary headaches. Several studies have confirmed the efficacy of acupuncture therapies for TTH, but it is uncertain which treatment is most effective. Objective This study a…
View article: Maresin1 can be a potential therapeutic target for nerve injury
Maresin1 can be a potential therapeutic target for nerve injury Open
Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic integrity is destroyed, causing inflammation a…
View article: Effectiveness and safety of acupuncture for children with cerebral palsy: An overview of systematic reviews
Effectiveness and safety of acupuncture for children with cerebral palsy: An overview of systematic reviews Open
Evidence on the effectiveness and safety of acupuncture for cerebral palsy (CP) is inconsistent, and methodological quality has not been comprehensively assessed in systematic reviews (SRs) or meta-analyses (MAs). This overview aims to int…
View article: Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway
Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway Open
The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress cause…
View article: Adipose-Derived Mesenchymal Stem Cells Combined With Extracellular Vesicles May Improve Amyotrophic Lateral Sclerosis
Adipose-Derived Mesenchymal Stem Cells Combined With Extracellular Vesicles May Improve Amyotrophic Lateral Sclerosis Open
The complexity of central nervous system diseases together with their intricate pathogenesis complicate the establishment of effective treatment strategies. Presently, the superiority of adipose-derived mesenchymal stem cells (ADSCs) on ne…
View article: Soliloquy of Colored Contact Lenses
Soliloquy of Colored Contact Lenses Open
View article: Efficacy and safety of acupuncture for senile insomnia
Efficacy and safety of acupuncture for senile insomnia Open
Background: Senile insomnia seriously affects the quality of life of the elderly. With the increase of the proportion of insomnia in the elderly, compared with the elderly with normal sleep quality, the elderly with long-term insomnia are …
View article: Efficacy and safety of acupuncture for senile insomnia: a protocol of systematic review and meta-analysis
Efficacy and safety of acupuncture for senile insomnia: a protocol of systematic review and meta-analysis Open
Review question / Objective: Is acupuncture efficacy and safety for senile insomnia?Condition being studied: Senile insomnia.Eligibility criteria: ①Patients(≥60 years) with senile insomnia regardless of any age and gender; ②Rndomized contr…
View article: Primary neuroendocrine carcinoma of the breast with markedly elevated alpha-fetoprotein: a case report
Primary neuroendocrine carcinoma of the breast with markedly elevated alpha-fetoprotein: a case report Open
Primary neuroendocrine carcinoma of the breast (PNECB) is a relatively rare subtype of breast cancer that has seldom been studied since its initial description. At present, the pathogenesis of the disease remains unknown, and there exit no…
View article: Effects of Disability Type on the Association between Age and Non-Communicable Disease Risk Factors among Elderly Persons with Disabilities in Shanghai, China
Effects of Disability Type on the Association between Age and Non-Communicable Disease Risk Factors among Elderly Persons with Disabilities in Shanghai, China Open
Little is known about differences in the association between age and risk factors of non-communicable diseases (NCDs), according to the disability type in Chinese elderly persons with disabilities. Thus, we examined the effects of these di…
View article: Association of STMN1 with survival in solid tumors: A systematic review and meta-analysis
Association of STMN1 with survival in solid tumors: A systematic review and meta-analysis Open
Background: The prognostic value of Stathmin 1 (STMN1) in malignant solid tumors remains controversial. Thus, we conducted this meta-analysis to summarize the potential value of STMN1 as a biomarker for predicting overall survival in patie…
View article: Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis
Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis Open
A consensus about the prognostic role of NIMA-related kinase 2 (NEK2) expression in various solid tumors has not been made yet. Thus, this meta-analysis aimed to systematically assess the prognostic role of NEK2 expression in patients with…
View article: ESMPE: A combined strategy for school tuberculosis prevention and control proposed by Dalian, China
ESMPE: A combined strategy for school tuberculosis prevention and control proposed by Dalian, China Open
The ESMPE strategy has shown a favorable effect on TB prevention and control in Dalian schools. More systematic evidence is needed on the effect of this strategy in reducing the incidence of TB in schools from other settings prior to its f…