Fang Xie
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View article: Efficient butanol bioproduction from renewable lignocellulosic biomass by an integrated strategy of ternary deep eutectic solvent pretreatment and clostridial fermentation: toward complete utilization of reed straw
Efficient butanol bioproduction from renewable lignocellulosic biomass by an integrated strategy of ternary deep eutectic solvent pretreatment and clostridial fermentation: toward complete utilization of reed straw Open
The main route for biobutanol production is anaerobic clostridial fermentation using corn and sugarcane as substrates. The high-price of raw materials in above processes largely limits its application as an advanced biofuel. The renewable …
View article: Determining transgender identity: a discussion from legal, medical, and social perspectives
Determining transgender identity: a discussion from legal, medical, and social perspectives Open
As societal awareness of gender diversity continues to evolve, the legal and social recognition of transgender identities has emerged as a critical global issue. Transgender individuals encounter a range of legal challenges that necessitat…
View article: A humanized anti-Toll like receptor 4 antibody Fab fragment inhibits pro-inflammatory responses induced by lipopolysaccharide through TLR4 in vitro and in vivo
A humanized anti-Toll like receptor 4 antibody Fab fragment inhibits pro-inflammatory responses induced by lipopolysaccharide through TLR4 in vitro and in vivo Open
Introduction: Toll like receptor 4 (TLR4) and its co-receptor MD-2 recognize bacterial lipopolysaccharide (LPS), initiating responses to infections caused by Gram-negative bacteria. TLR4 also plays a role in various pathological processes,…
View article: Effects of Pineapple Peel on the Nutritional and Microbial Profiles of Napier Grass–Sugarcane Top Silage
Effects of Pineapple Peel on the Nutritional and Microbial Profiles of Napier Grass–Sugarcane Top Silage Open
Agricultural byproducts, including pineapple peel (PP), are valuable feed additives which support the livestock industry. However, conflicting evidence exists regarding the optimal amount of PP required to achieve optimal fermentation in s…
View article: MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens
MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens Open
Methylthioadenosine phosphorylase ( MTAP ) gene deletions are frequent in human cancers. Loss of MTAP leads to significantly increased cellular levels of methylthioadenosine (MTA), a cellular metabolite and specific inhibitor of the cell-e…
View article: TCA Cycle Intermediate Mitigates Di(2‐ethylhexyl) Phthalate‐Induced Cholestatic Liver Injury Through Modulation of the Nrf2/NQO1 Signalling Axis
TCA Cycle Intermediate Mitigates Di(2‐ethylhexyl) Phthalate‐Induced Cholestatic Liver Injury Through Modulation of the Nrf2/NQO1 Signalling Axis Open
As a commonly used phthalate compound, di(2‐ethylhexyl) phthalate (DEHP) has been shown to disrupt the tricarboxylic acid (TCA) cycle and aggravate tissue damage. However, whether the TCA cycle is involved in cholestatic liver injury (CLI)…
View article: From DNA-Encoded Library Screening to <b>AM-9747</b>: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy
From DNA-Encoded Library Screening to <b>AM-9747</b>: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy Open
Inhibition of the methyltransferase enzyme PRMT5 by MTA accumulation is a vulnerability of MTAP-deleted cancers. Herein, we report the discovery and optimization of a quinolin-2-amine DEL hit that cooperatively binds PRMT5:MEP50 and MTA to…
View article: Fibrolytic Enzymes and Lactic Acid Bacteria Improve the Ensiling Characteristics of Ramie and Elephant Grass Mixed Silage
Fibrolytic Enzymes and Lactic Acid Bacteria Improve the Ensiling Characteristics of Ramie and Elephant Grass Mixed Silage Open
Understanding the effects of bacteria and enzyme addition on mixed crop silage is imperative for dairy producers to make informed decisions. The current study evaluated the chemical changes in silage prepared from different ramie and eleph…
View article: Efficient production of fermentable sugars from common reed biomass through hydrothermal and citric acid pretreatment processes
Efficient production of fermentable sugars from common reed biomass through hydrothermal and citric acid pretreatment processes Open
Producing fermentable sugars from lignocellulosic biomass could provide renewable substrate for biofuel production by microbial fermentation. However, the structure of lignocellulose hinders enzymatic saccharification efficiency to obtain …
View article: Deciphering the Exact Sequence of Endogenous Soluble B Cell Maturation Antigen and Unbiased Quantitation in Multiple Myeloma Patient Samples by LC-MS
Deciphering the Exact Sequence of Endogenous Soluble B Cell Maturation Antigen and Unbiased Quantitation in Multiple Myeloma Patient Samples by LC-MS Open
Background B-cell maturation antigen is a pivotal therapeutic target for multiple myeloma (MM). Membrane-bound BCMA can be cleaved by γ-secretase and shed as soluble BCMA (sBCMA). sBCMA can act as a neutralizing sink to compete with drug, …
View article: Imidazolone as an Amide Bioisostere in the Development of β-1,3-<i>N</i>-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors
Imidazolone as an Amide Bioisostere in the Development of β-1,3-<i>N</i>-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors Open
B3GNT2 is responsible for elongation of cell surface long-chain polylactosamine, which influences the regulation of the immune response, making it an attractive target for immunomodulation. In the development of amide containing B3GNT2 inh…
View article: RNA-Seq combined with population-level analysis reveals important candidate genes related to seed size in flax (Linum usitatissimum L.)
RNA-Seq combined with population-level analysis reveals important candidate genes related to seed size in flax (Linum usitatissimum L.) Open
Seed size is a key determinant of crop yields. Understanding the regulatory mechanisms of seed size is beneficial for improving flax seed yield. In this study, the development of large flax seeds lagged behind that of small seeds, and 1,75…
View article: Adaptive Response and Transcriptomic Analysis of Flax (Linum usitatissimum L.) Seedlings to Salt Stress
Adaptive Response and Transcriptomic Analysis of Flax (Linum usitatissimum L.) Seedlings to Salt Stress Open
Soil salinity constrains agricultural development in arid regions. Flax is an economically important crop in many countries, and screening or breeding salinity-resistant flax cultivars is necessary. Based on the previous screening of flaxs…
View article: Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum
Adiponectin Influences FGF2 in the Developing Porcine Corpus Luteum Open
Luteal angiogenesis is regulated by pro-angiogenic hormones including fibroblast growth factor 2 (FGF2) and angiopoietin 1 (Ang1), which are regulated by the adipokine leptin during development. Another adipokine, adiponectin, exhibits an …