Huikang Xie
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View article: Primary lung cancer with duodenal metastasis complicated by obstructive jaundice and pancreatitis: a case report
Primary lung cancer with duodenal metastasis complicated by obstructive jaundice and pancreatitis: a case report Open
Background Primary lung adenocarcinoma with duodenal metastasis is relatively rare, and its early clinical symptoms are often insidious, making diagnosis challenging. CT, MR, PET-CT, and gastroscopy can effectively identify gastrointestina…
View article: Correlation analysis between clinical characteristics of adult patients with Mycoplasma pneumoniae pneumonia and 23S rRNA A2063 gene in alveolar lavage fluid
Correlation analysis between clinical characteristics of adult patients with Mycoplasma pneumoniae pneumonia and 23S rRNA A2063 gene in alveolar lavage fluid Open
View article: The Application of Transbronchial Cryo-biopsy in the Diagnosis of Pulmonary Alveolar Proteinosis
The Application of Transbronchial Cryo-biopsy in the Diagnosis of Pulmonary Alveolar Proteinosis Open
Background: Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by abnormal alveolar surfactant accumulation. In recent years, transbronchial cryo-biopsy (TBCB) has gradually been applied as it can obtain larger and better…
View article: Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury
Targeting mitochondrial complex I of CD177+ neutrophils alleviates lung ischemia-reperfusion injury Open
Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality following lung transplantation, with neutrophils playing a central role in its inflammatory pathology. Here, we employ single-cell RNA sequencing and spa…
View article: Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules
Proteogenomic characterization reveals tumorigenesis and progression of lung cancer manifested as subsolid nodules Open
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. Nevertheless, the precise clinical management of SSNs necessitates a profound understanding of their tumorigenesis and progression. Here, we analy…
View article: Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report
Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report Open
View article: Limited resection is comparable to lobectomy for tumor size ≤ 2 cm pulmonary invasive mucinous adenocarcinoma
Limited resection is comparable to lobectomy for tumor size ≤ 2 cm pulmonary invasive mucinous adenocarcinoma Open
View article: An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure Open
The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher the immune dynamics during human LUAD devel…
View article: The Application of Transbronchial Cryo-biopsy in the Diagnosis of Pulmonary Alveolar Proteinosis
The Application of Transbronchial Cryo-biopsy in the Diagnosis of Pulmonary Alveolar Proteinosis Open
Background Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by abnormal alveolar surfactant accumulation. The small tissue specimens obtained by transbronchial lung biopsy (TBLB) could not adequately meet the need for s…
View article: Hypoxia-Derived Exosomes Promote Lung Adenocarcinoma by Regulating HS3ST1-GPC4-Mediated Glycolysis
Hypoxia-Derived Exosomes Promote Lung Adenocarcinoma by Regulating HS3ST1-GPC4-Mediated Glycolysis Open
Objective: The diagnosis of lung adenocarcinoma (LUAD) is often delayed due to the typically asymptomatic nature of the early-stage disease, causing advanced-stage LUAD diagnosis in most patients. Hypoxia is widely recognized as a driving …
View article: Case report: Fibrotic interstitial lung disease as the initial manifestation of hereditary pulmonary alveolar proteinosis caused by CSF2RB mutation
Case report: Fibrotic interstitial lung disease as the initial manifestation of hereditary pulmonary alveolar proteinosis caused by CSF2RB mutation Open
A 50-year-old male was admitted to the hospital with a 3-year history of dyspnea and cough. Chest high-resolution computed tomography (HRCT) did not show typical features of pulmonary alveolar proteinosis (PAP), but rather atypical feature…
View article: Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation
Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation Open
Lung ischemia–reperfusion injury (IRI) stands as the primary culprit behind primary graft dysfunction (PGD) after lung transplantation, yet viable therapeutic options are lacking. In the present study, we used a murine hilar clamp (1 h) an…
View article: Erratum to “Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation”
Erratum to “Inhibition of ALOX12–12-HETE Alleviates Lung Ischemia–Reperfusion Injury by Reducing Endothelial Ferroptosis-Mediated Neutrophil Extracellular Trap Formation” Open
[This corrects the article DOI: 10.34133/2022/9873203.].
View article: MA20.03 The Value of Lepidic and Invasion Pattern NEW Diagnostic Criteria for the Differential Diagnosis of in AIS, MIA from Invasive Adenocarcinoma
MA20.03 The Value of Lepidic and Invasion Pattern NEW Diagnostic Criteria for the Differential Diagnosis of in AIS, MIA from Invasive Adenocarcinoma Open
View article: Development of the semi-dry dot-blot method for intraoperative detecting micropapillary component in lung adenocarcinoma based on proteomics analysis
Development of the semi-dry dot-blot method for intraoperative detecting micropapillary component in lung adenocarcinoma based on proteomics analysis Open
View article: Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity
Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity Open
Enhancing chemosensitivity is one of the largest unmet medical needs in cancer therapy. Cyclic GMP-AMP synthase (cGAS) connects genome instability caused by platinum-based chemotherapeutics to type I interferon (IFN) response. Here, by usi…
View article: Small airway dysfunction in idiopathic pulmonary fibrosis
Small airway dysfunction in idiopathic pulmonary fibrosis Open
It is generally accepted that the pathophysiology of idiopathic pulmonary fibrosis (IPF) can be attributed to impaired lung interstitium and alveoli, while airway involvement has rarely been reported. In the present study, we aimed to inve…
View article: Small airway dysfunction in idiopathic pulmonary fibrosis
Small airway dysfunction in idiopathic pulmonary fibrosis Open
The pathophysiology of IPF is generally considered to be impaired lung interstitium and alveoli but rare airway involvement. The objective of this study is to investigate the actual occurrence of IPF comorbid small airway dysfunction (SAD)…
View article: Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing
Deconstructing the intra-tumor subclonal heterogeneity of lung synchronous ground-glass nodules using whole-genome sequencing Open
View article: Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study
Immune checkpoint inhibitors plus chemotherapy in patients with locally advanced or metastatic pulmonary sarcomatoid carcinoma: a multicentric real-world study Open
Introduction: Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy as monotherapy in patients with pulmonary sarcomatoid carcinoma (PSC). We performed the current multi-institutional, real-world study to assess the effi…
View article: [Retracted] HS3ST1 Promotes Non‐Small‐Cell Lung Cancer Progression by Targeting the SPOP/FADD/NF‐κB Pathway
[Retracted] HS3ST1 Promotes Non‐Small‐Cell Lung Cancer Progression by Targeting the SPOP/FADD/NF‐κB Pathway Open
Heparan sulfate proteoglycan is a key component of cell microenvironment and plays an important role in cell‐cell interaction, adhesion, migration, and signal transduction. Heparan sulfate 3‐O‐sulfotransferase 1 (HS3ST1) is a metabolic‐rel…
View article: Low baseline plasma <scp>PCSK9</scp> level is associated with good clinical outcomes of immune checkpoint inhibitors in advanced non‐small cell lung cancer
Low baseline plasma <span>PCSK9</span> level is associated with good clinical outcomes of immune checkpoint inhibitors in advanced non‐small cell lung cancer Open
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial protein involved in the metabolism of low‐density lipoprotein cholesterol. However, the role of plasma PCSK9 in predicting the efficacy of ICIs in advanced non‐s…
View article: [The Earliest Stage of Lung Adenocarcinoma:
the Pathological Diagnosis and Clinical Significance of Adenocarcinoma In Situ].
[The Earliest Stage of Lung Adenocarcinoma:
the Pathological Diagnosis and Clinical Significance of Adenocarcinoma In Situ]. Open
The International Agency for Research on Cancer (IARC) published the World Health Organization (WHO) classification of thoracic tumors (5th edition) in May 2021, only six years after the 4th edition of WHO Classification. With the applicat…
View article: Morphological Subtypes of Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: Prognostic Heterogeneity and Its Underlying Mechanism
Morphological Subtypes of Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: Prognostic Heterogeneity and Its Underlying Mechanism Open
Background Tumor spread through air spaces (STAS) has three morphologic subtypes: single cells, micropapillary clusters, and solid nests. However, whether their respective clinical significance is similar remains unclear. Methods We retros…
View article: Comprehensive study of neoadjuvant targeted therapy for resectable non-small cell lung cancer
Comprehensive study of neoadjuvant targeted therapy for resectable non-small cell lung cancer Open
Neoadjuvant EGFR-TKIs had good effects on EGFR-mutant NSCLC patients at different stages, especially those with MPR. Patients with high-risk subtypes (solid or micropapillary) should be closely followed up after surgery because of t…
View article: Different clinical features between patients with <i>ROS1</i>-positive and <i>ALK</i>-positive advanced non-small cell lung cancer
Different clinical features between patients with <i>ROS1</i>-positive and <i>ALK</i>-positive advanced non-small cell lung cancer Open
Objective To compare the baseline clinical characteristics between patients with ROS1-positive and ALK-positive advanced non-small cell lung cancer (NSCLC), and the correlations of these subtypes with the distribution of metastases. Method…
View article: Predictors of upstage and treatment strategies for stage IA lung cancers after sublobar resection for adenocarcinoma in situ and minimally invasive adenocarcinoma
Predictors of upstage and treatment strategies for stage IA lung cancers after sublobar resection for adenocarcinoma in situ and minimally invasive adenocarcinoma Open
Timely complementary treatment is encouraged in AIS/MIA upstaged to invasive adenocarcinoma based on the FP after sublobar resection to avoid local recurrence. Pathologists should be more cautious about AIS and MIA with tumor size ≥1 cm to…
View article: Druggable driver gene alterations in redefined large cell carcinoma in Chinese patients: an observational study
Druggable driver gene alterations in redefined large cell carcinoma in Chinese patients: an observational study Open
Under the 2015 WHO criteria, LCC was more frequently detected in elderly male patients with inferior prognoses. The frequency of EGFR and KRAS mutations was found to be the highest. Mutations in EGFR occurred more freq…
View article: Recognition of filigree pattern expands the concept of micropapillary subtype in patients with surgically resected lung adenocarcinoma
Recognition of filigree pattern expands the concept of micropapillary subtype in patients with surgically resected lung adenocarcinoma Open
View article: Eliminating Radiation Resistance of Non-Small Cell Lung Cancer by Dihydroartemisinin Through Abrogating Immunity Escaping and Promoting Radiation Sensitivity by Inhibiting PD-L1 Expression
Eliminating Radiation Resistance of Non-Small Cell Lung Cancer by Dihydroartemisinin Through Abrogating Immunity Escaping and Promoting Radiation Sensitivity by Inhibiting PD-L1 Expression Open
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, and dihydroartemisinin (DHA) could synergi…