Wei Xie
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View article: Rapid detection of 11 common drugs in domestic sewage by pulsed direct current electrospray ionization mass spectrometry
Rapid detection of 11 common drugs in domestic sewage by pulsed direct current electrospray ionization mass spectrometry Open
Drugs and their metabolites are ubiquitous in various environmental media， including water bodies， soil， sediment， and air. These substances pose significant risks to human and animal safety and have emerged as a new category of pollutants…
View article: Oral Prodrug of a Novel Glutathione Surrogate Reverses Metabolic Dysregulation and Attenuates Neurodegenerative Process in Transgenic Alzheimer’s Mice
Oral Prodrug of a Novel Glutathione Surrogate Reverses Metabolic Dysregulation and Attenuates Neurodegenerative Process in Transgenic Alzheimer’s Mice Open
Glycation-induced oxidative stress underlies the numerous metabolic ravages of Alzheimer's disease (AD). Reduced glutathione levels in AD lead to increased oxidative stress, including glycation-induced pathology. Previously, we showed that…
View article: Worldwide rooftop photovoltaic electricity generation may mitigate global warming
Worldwide rooftop photovoltaic electricity generation may mitigate global warming Open
Rooftop photovoltaic (RPV) is often understood as a niche contribution to climate change mitigation. However, the global potential of RPVs to mitigate global warming is unknown. Here we map the global rooftop area at 1-km resolution, quant…
View article: Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice
Oral prodrug of a novel glutathione surrogate reverses metabolic dysregulation and attenuates neurodegenerative process in APP/PS1 mice Open
Glycation-induced oxidative stress underlies the numerous metabolic ravages of Alzheimer’s disease (AD). Reduced glutathione levels in AD lead to increased oxidative stress, including glycation-induced pathology. Previously, we showed that…
View article: Comparison of inactivation characteristics of Escherichia coli and Staphylococcus aureus in water by rotary plasma jet sterilization
Comparison of inactivation characteristics of Escherichia coli and Staphylococcus aureus in water by rotary plasma jet sterilization Open
This study aims to investigate the differential inactivation responses of Escherichia coli and Staphylococcus aureus under rotary plasma jet conditions. Initially, we examined the antimicrobial effects of the rotary plasma jet on the two m…
View article: Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice
Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice Open
Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is ess…
View article: Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice
Deletion of Glyoxalase 1 exacerbates acetaminophen-induced hepatotoxicity in mice Open
Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC) has a narrow therapeutic window and early treatment is essent…
View article: Hyperspectral analysis of amyloid beta (Aβ) evolutional changes in preclinical to late‐stage Alzheimer’s disease using matched brain and retinal tissue
Hyperspectral analysis of amyloid beta (Aβ) evolutional changes in preclinical to late‐stage Alzheimer’s disease using matched brain and retinal tissue Open
Background Alzheimer’s disease (AD) is a progressive, degenerative brain disorder that leads to cognitive impairment and eventually death. It is marked by buildup of abnormal amyloid aggregates (Aβ) in the brain. This study aimed to elucid…
View article: Sulfanegen, a 3‐mercaptopyruvate sulfurtransferase substrate, as a therapeutic option for Alzheimer’s disease
Sulfanegen, a 3‐mercaptopyruvate sulfurtransferase substrate, as a therapeutic option for Alzheimer’s disease Open
Background The oxidative stress evident in the Alzheimer’s disease (AD) brain leads to compromised 3‐mercaptopyruvate sulfurtransferase (3MST) function, one of the endogenous hydrogen sulfide (H 2 S) producing enzymes. 1,2 Impaired 3MST fu…
View article: Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity
Geometric Isomer of Guanabenz Confers Hepatoprotection to a Murine Model of Acetaminophen Toxicity Open
Overdose of acetaminophen, a widely used antipyretic and analgesic drug, is one of the leading causes of drug-induced acute liver injury in the United States and worldwide. Phase-I metabolism of acetaminophen generates the toxic N-acetyl-p…
View article: Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer’s Disease
Orally Bioavailable Prodrugs of ψ-GSH: A Potential Treatment for Alzheimer’s Disease Open
Addressing glycation-induced oxidative stress in Alzheimer's disease (AD) is an emerging pharmacotherapeutic strategy. Restoration of the brain glyoxalase enzyme system that neutralizes reactive dicarbonyls is one such approach. Toward thi…
View article: Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo
Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo Open
Increased oxidative stress and inflammation are implicated in the pathogenesis of Alzheimer's disease. Treatment with hydrogen sulfide (H2S) and H2S donors such as sodium hydrosulfide (NaSH) can reduce oxidative stress in preclinical studi…
View article: Dipeptide of ψ-GSH Inhibits Oxidative Stress and Neuroinflammation in an Alzheimer’s Disease Mouse Model
Dipeptide of ψ-GSH Inhibits Oxidative Stress and Neuroinflammation in an Alzheimer’s Disease Mouse Model Open
Supplementation of glutathione (GSH) levels through varying formulations or precursors has thus far appeared to be a tenable strategy to ameliorate disease-associated oxidative stress. Metabolic liability of GSH and its precursors, i.e., h…
View article: Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid
Angiotensin-converting enzyme gates brain circuit–specific plasticity via an endogenous opioid Open
Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin I to produce angiotensin II. In the brain, ACE is especially abundant in striatal tissue, but the function of ACE in striatal circuits remains poorly unde…
View article: γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer’s Disease-like Pathology and Neurodegeneration in a Mouse Model
γ-Glutamyl-Transpeptidase-Resistant Glutathione Analog Attenuates Progression of Alzheimer’s Disease-like Pathology and Neurodegeneration in a Mouse Model Open
Oxidative stress in Alzheimer’s disease (AD) is mediated, in part, by the loss of glutathione (GSH). Previous studies show that γ-glutamyl transpeptidase (GGT)-resistant GSH analog, Ψ-GSH, improves brain GSH levels, reduces oxidative stres…
View article: Angiotensin-converting enzyme governs endogenous opioid signaling and synaptic plasticity in nucleus accumbens
Angiotensin-converting enzyme governs endogenous opioid signaling and synaptic plasticity in nucleus accumbens Open
Angiotensin-converting enzyme (ACE) regulates blood pressure by cleaving angiotensin I to produce angiotensin II. In the brain, ACE is expressed at uniquely high levels in the striatonigral pathway, but its central function remains poorly …