Zhiqin Xie
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View article: A dual fluorescence channel RAA-based CRISPR-Cas12a/Cas13a system for highly sensitive detection of <i>Gyrovirus galga1</i> and <i>Gyrovirus homsa1</i>
A dual fluorescence channel RAA-based CRISPR-Cas12a/Cas13a system for highly sensitive detection of <i>Gyrovirus galga1</i> and <i>Gyrovirus homsa1</i> Open
Gyrovirus galga1 (GyG1) and Gyrovirus homsa1 (GyH1) are the second and third most common gyroviruses identified, respectively, after chicken anaemia virus. They were first reported in 2011 and are currently prevalent worldwid…
View article: Identifying central symptom clusters and correlates among post-COVID-19 pulmonary fibrosis patients: a network analysis
Identifying central symptom clusters and correlates among post-COVID-19 pulmonary fibrosis patients: a network analysis Open
Background Previous studies have analyzed symptom clusters in patients with coronavirus disease 2019 (COVID-19); however, evidence regarding the core symptom clusters and their influencing factors in patients with post-COVID-19 pulmonary f…
View article: Transcriptome Analysis Reveals the Pivotal Genes and Regulation Pathways Under Cold Stress and Identifies SbERF027, an AP2/ERF Gene That Confers Cold Tolerance in Sorghum
Transcriptome Analysis Reveals the Pivotal Genes and Regulation Pathways Under Cold Stress and Identifies SbERF027, an AP2/ERF Gene That Confers Cold Tolerance in Sorghum Open
Low temperature at the seedling stage adversely affects sorghum growth and development and limits its geographical distribution. APETALA2/Ethylene-Responsive transcription factors (AP2/ERFs), one of the largest transcription factor familie…
View article: Genotype switching in hepatitis B virus as a potential risk for vertical transmission from mother-to-child was first reported
Genotype switching in hepatitis B virus as a potential risk for vertical transmission from mother-to-child was first reported Open
View article: Overexpression of OsTTG1 Influences Seed Size and Silique Length in Arabidopsis Thaliana
Overexpression of OsTTG1 Influences Seed Size and Silique Length in Arabidopsis Thaliana Open
View article: The Knob Domain of the Fiber-1 Protein Affects the Replication of Fowl Adenovirus Serotype 4
The Knob Domain of the Fiber-1 Protein Affects the Replication of Fowl Adenovirus Serotype 4 Open
Fowl adenovirus serotype 4 (FAdV-4) outbreaks have caused significant economic losses in the Chinese poultry industry since 2015. The relationships among viral structural proteins in infected hosts are relatively unknown. To explore the ro…
View article: Differences in the pathogenicity and molecular characteristics of fowl adenovirus serotype 4 epidemic strains in Guangxi Province, southern China
Differences in the pathogenicity and molecular characteristics of fowl adenovirus serotype 4 epidemic strains in Guangxi Province, southern China Open
Starting in 2015, the widespread prevalence of hydropericardium-hepatitis syndrome (HHS) has led to considerable financial losses within China’s poultry farming industry. In this study, pathogenicity assessments, whole-genome sequencing, a…
View article: Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts
Deoxynivalenol triggers mitotic catastrophe and apoptosis in C2C12 myoblasts Open
Deoxynivalenol (DON), commonly known as vomitoxin, is a mycotoxin produced by fungi and is frequently found as a contaminant in various cereal-based food worldwide. While the harmful effects of DON have been extensively studied in differen…
View article: Biological features of fowl adenovirus serotype-4
Biological features of fowl adenovirus serotype-4 Open
Fowl adenovirus serotype 4 (FAdV-4) is highly pathogenic to broilers aged 3 to 5 weeks and has caused considerable economic loss in the poultry industry worldwide. FAdV-4 is the causative agent of hydropericardium-hepatitis syndrome (HHS) …
View article: SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development
SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development Open
SRSF2 plays a dual role, functioning both as a transcriptional regulator and a key player in alternative splicing. The absence of SRSF2 in MyoD+ progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle def…
View article: SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development
SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development Open
SRSF2 plays a dual role, functioning both as a transcriptional regulator and a key player in alternative splicing. The absence of SRSF2 in MyoD+ progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle def…
View article: Analysis of Chicken IFITM3 Gene Expression and Its Effect on Avian Reovirus Replication
Analysis of Chicken IFITM3 Gene Expression and Its Effect on Avian Reovirus Replication Open
Interferon-inducible transmembrane protein 3 (IFITM3) is an antiviral factor that plays an important role in the host innate immune response against viruses. Previous studies have shown that IFITM3 is upregulated in various tissues and org…
View article: A sandwich amperometric immunosensor for the detection of fowl adenovirus group I based on bimetallic Pt/Ag nanoparticle-functionalized multiwalled carbon nanotubes
A sandwich amperometric immunosensor for the detection of fowl adenovirus group I based on bimetallic Pt/Ag nanoparticle-functionalized multiwalled carbon nanotubes Open
An enzyme-free sandwich amperometric immunosensor based on bimetallic Pt/Ag nanoparticle (Pt/AgNPs)-functionalized chitosan (Chi)-modified multiwalled carbon nanotubes (MWCNTs) as dual signal amplifiers and Chi-modified MWCNTs (MWCNTs-Chi)…
View article: Roles and functions of IAV proteins in host immune evasion
Roles and functions of IAV proteins in host immune evasion Open
Influenza A viruses (IAVs) evade the immune system of the host by several regulatory mechanisms. Their genomes consist of eight single-stranded segments, including nonstructural proteins (NS), basic polymerase 1 (PB1), basic polymerase 2 (…
View article: Transcriptomic and Translatomic Analyses Reveal Insights into the Signaling Pathways of the Innate Immune Response in the Spleens of SPF Chickens Infected with Avian Reovirus
Transcriptomic and Translatomic Analyses Reveal Insights into the Signaling Pathways of the Innate Immune Response in the Spleens of SPF Chickens Infected with Avian Reovirus Open
Avian reovirus (ARV) infection is prevalent in farmed poultry and causes viral arthritis and severe immunosuppression. The spleen plays a very important part in protecting hosts against infectious pathogens. In this research, transcriptome…
View article: Chicken IFI6 inhibits avian reovirus replication and affects related innate immune signaling pathways
Chicken IFI6 inhibits avian reovirus replication and affects related innate immune signaling pathways Open
Interferon-alpha inducible protein 6 (IFI6) is an important interferon-stimulated gene. To date, research on IFI6 has mainly focused on human malignant tumors, virus-related diseases and autoimmune diseases. Previous studies have shown tha…
View article: Molecular characterization of emerging chicken and turkey parvovirus variants and novel strains in Guangxi, China
Molecular characterization of emerging chicken and turkey parvovirus variants and novel strains in Guangxi, China Open
Avian parvoviruses cause several enteric poultry diseases that have been increasingly diagnosed in Guangxi, China, since 2014. In this study, the whole-genome sequences of 32 strains of chicken parvovirus (ChPV) and 3 strains of turkey par…
View article: Pathogenicity and molecular characteristics of fowl adenovirus serotype 4 with moderate virulence in Guangxi Province, China
Pathogenicity and molecular characteristics of fowl adenovirus serotype 4 with moderate virulence in Guangxi Province, China Open
The GX2020-019 strain of fowl adenovirus serotype 4 (FAdV-4) was isolated from the liver of chickens with hydropericardium hepatitis syndrome in Guangxi Province, China, and was purified by plaque assay three times. Pathogenicity studies s…
View article: Phylogeny and Pathogenicity of Subtype XIIb NDVs from Francolins in Southwestern China and Effective Protection by an Inactivated Vaccine
Phylogeny and Pathogenicity of Subtype XIIb NDVs from Francolins in Southwestern China and Effective Protection by an Inactivated Vaccine Open
Most genotype XII newcastle disease viruses (NDVs) were isolated from poultry, chickens, or geese, with the exception of one subtype, XIIa NDV, which was isolated from a peacock. Here, two subtype XIIb NDVs, francolin/China/GX01/2017 and f…
View article: Supplementary Figures 1 through 5 and Supplementary Tables 1 through 4 from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Supplementary Figures 1 through 5 and Supplementary Tables 1 through 4 from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development Open
Supplementary Fig S1. SRSF2 increases colony-forming efficiencies of hepatocarcinoma cells. Supplementary Fig S2. Exogenous expression of SRSF2 in KD cells restores WT splicing patterns of SRSF2-targeted transcripts. Supplementary Fig S3. …
View article: Data from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Data from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development Open
Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the underlying mechanisms remain mainly obscure. Here, we report that the splicing factor SRSF2 is upregulated frequently in human hepatocellular carcinoma (HCC)…
View article: Supplementary Figures 1 through 5 and Supplementary Tables 1 through 4 from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Supplementary Figures 1 through 5 and Supplementary Tables 1 through 4 from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development Open
Supplementary Fig S1. SRSF2 increases colony-forming efficiencies of hepatocarcinoma cells. Supplementary Fig S2. Exogenous expression of SRSF2 in KD cells restores WT splicing patterns of SRSF2-targeted transcripts. Supplementary Fig S3. …
View article: Data from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development
Data from SRSF2 Regulates Alternative Splicing to Drive Hepatocellular Carcinoma Development Open
Aberrant RNA splicing is recognized to contribute to cancer pathogenesis, but the underlying mechanisms remain mainly obscure. Here, we report that the splicing factor SRSF2 is upregulated frequently in human hepatocellular carcinoma (HCC)…
View article: Development of a visual multiplex fluorescent LAMP assay for the detection of foot-and-mouth disease, vesicular stomatitis and bluetongue viruses
Development of a visual multiplex fluorescent LAMP assay for the detection of foot-and-mouth disease, vesicular stomatitis and bluetongue viruses Open
Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification technique that can be used to amplify target genes at a constant temperature, and it has several advantages, including convenience, specificity and sensitivity. …
View article: An Enzyme-Free Sandwich Amperometry-Type Immunosensor Based on Au/Pt Nanoparticle-Functionalized Graphene for the Rapid Detection of Avian Influenza Virus H9 Subtype
An Enzyme-Free Sandwich Amperometry-Type Immunosensor Based on Au/Pt Nanoparticle-Functionalized Graphene for the Rapid Detection of Avian Influenza Virus H9 Subtype Open
View article: Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5
Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5 Open
Avian reovirus (ARV) infection can lead to severe immunosuppression, complications, and secondary diseases, causing immense economic losses to the poultry industry. In-depth study of the mechanism by which the innate immune system combats …
View article: Exclusion of NUMB Exon12 Controls Cancer Cell Migration Through Regulation of Notch1-SMAD3 Crosstalk
Exclusion of NUMB Exon12 Controls Cancer Cell Migration Through Regulation of Notch1-SMAD3 Crosstalk Open
View article: Molecular characterization of chicken anemia virus in Guangxi Province, southern China, from 2018 to 2020
Molecular characterization of chicken anemia virus in Guangxi Province, southern China, from 2018 to 2020 Open
Subgroup C3 was the dominant genotype in Guangxi Province from 2018-2020. The 20 CAV strains in this study might be virulent according to the amino acid residue analysis. These data help improve our understanding of the epidemiological tre…
View article: Survey of low pathogenic avian influenza viruses in live poultry markets in Guangxi Province, Southern China, 2016–2019
Survey of low pathogenic avian influenza viruses in live poultry markets in Guangxi Province, Southern China, 2016–2019 Open
View article: Epidemiological Surveillance of Parvoviruses in Commercial Chicken and Turkey Farms in Guangxi, Southern China, During 2014–2019
Epidemiological Surveillance of Parvoviruses in Commercial Chicken and Turkey Farms in Guangxi, Southern China, During 2014–2019 Open
A previously unidentified chicken parvovirus (ChPV) and turkey parvovirus (TuPV) strain, associated with runting-stunting syndrome (RSS) and poultry enteritis and mortality syndrome (PEMS) in turkeys, is now prevalent among chickens in Chi…