Xiaopei Shen
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View article: Genomic Profiling Identified a Mutational Signature Related to Female in Non-Smoking Lung Adenocarcinoma
Genomic Profiling Identified a Mutational Signature Related to Female in Non-Smoking Lung Adenocarcinoma Open
We identified a new mutational signature (S2) which is most enriched in LUAD in non-smokers and related to female and low-TMB. S2 mutational signature may help revealed female-related mutagenesis mechanisms and develop strategies for thera…
View article: Sexual Response Problems and Their Correlates Among Older Adults From the Sexual Well-Being (SWELL) Study in China: Multicenter Cross-Sectional Study
Sexual Response Problems and Their Correlates Among Older Adults From the Sexual Well-Being (SWELL) Study in China: Multicenter Cross-Sectional Study Open
Background Sexual response problems among older adults are not an inevitable consequence of aging but rather a response to sexual health. However, there is a lack of recent and multicenter data on this issue in China. Objective This study …
View article: An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study
An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study Open
Background Septic shock (SS) is a syndrome with high mortality. Early forewarning and diagnosis of SS, which are critical in reducing mortality, are still challenging in clinical management. Objective We propose a simple and fast risk-stra…
View article: Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing
Deciphering the impact of senescence in kidney transplant rejection: An integrative machine learning and multi-omics analysis via bulk and single-cell RNA sequencing Open
Background The demographic shift towards an older population presents significant challenges for kidney transplantation (KTx), particularly due to the vulnerability of aged donor kidneys to ischemic damage, delayed graft function, and redu…
View article: Qualitative Transcriptional Signature for Predicting the Pathological Response of Colorectal Cancer to FOLFIRI Therapy
Qualitative Transcriptional Signature for Predicting the Pathological Response of Colorectal Cancer to FOLFIRI Therapy Open
FOLFIRI (5-FU, leucovorin, irinotecan) is the first-line chemotherapy for metastatic colorectal cancer (mCRC), but response rates are under 50%. This study aimed to develop a predictive signature for FOLFIRI response in mCRC patients. Firs…
View article: Clinical phenotyping of septic shock with latent profile analysis: A retrospective multicenter study
Clinical phenotyping of septic shock with latent profile analysis: A retrospective multicenter study Open
The individualized identification of phenotypes is well suited to clinical practice. The three SS phenotypes differed significantly in pathophysiological and clinical outcomes, which are crucial for informing management decisions and progn…
View article: Qualitative serum microRNA signatures for lung cancer screening
Qualitative serum microRNA signatures for lung cancer screening Open
Background: Lung cancer is the leading cause of morbidity and mortality among cancers worldwide. The early detection of lung cancer can effectively reduce the mortality rates among patients. Therefore, this study aims to construct signatur…
View article: Single‐cell transcriptomic analysis of the senescent microenvironment in bone metastasis
Single‐cell transcriptomic analysis of the senescent microenvironment in bone metastasis Open
Bone metastasis (BM) is a mortality‐related event of late‐stage cancer, with non‐small cell lung cancer (NSCLC) being a common origin for BM. However, the detailed molecular profiling of the metastatic bone ecosystem is not fully understoo…
View article: The genetic duet of concurrent <i>RASAL1</i> and <i>PTEN</i> alterations promotes cancer aggressiveness by cooperatively activating the <scp>PI3K</scp>–<scp>AKT</scp> pathway
The genetic duet of concurrent <i>RASAL1</i> and <i>PTEN</i> alterations promotes cancer aggressiveness by cooperatively activating the <span>PI3K</span>–<span>AKT</span> pathway Open
The significance of the prominent tumor suppressor gene for RAS protein activator‐like 1 ( RASAL1 ) could be better understood by combined genetic, clinical, and functional studies. Here, we investigated the oncogenic and clinical impacts …
View article: Editorial: Decipherment of genetic architecture of psychiatric disorders via combination of multi-omics data
Editorial: Decipherment of genetic architecture of psychiatric disorders via combination of multi-omics data Open
Editorial: Decipherment of genetic architecture of psychiatric disorders via combination of multi-omics data
View article: Genetic trio of <i>BRAF</i> and <i>TERT</i> alterations and rs2853669TT in papillary thyroid cancer aggressiveness
Genetic trio of <i>BRAF</i> and <i>TERT</i> alterations and rs2853669TT in papillary thyroid cancer aggressiveness Open
Background BRAF V600E and TERT promoter alterations are core components in current genetics-based risk assessment for precision management of papillary thyroid cancer. It remains unknown whether this approach could achieve even better prec…
View article: RankDMG: a differentially methylated gene analysis method for three special scenarios
RankDMG: a differentially methylated gene analysis method for three special scenarios Open
Background Common methods of identification of differentially methylated genes (DMGs) mainly detect differences between case and control groups, which cannot tell whether a gene is differentially methylated in a specific disease sample (fi…
View article: Editorial: Novel approaches and concepts of biomarker discovery for cancer
Editorial: Novel approaches and concepts of biomarker discovery for cancer Open
EDITORIAL article Front. Genet., 24 August 2022Sec. Genomic Assay Technology https://doi.org/10.3389/fgene.2022.955062
View article: RNAPhaSep: a resource of RNAs undergoing phase separation
RNAPhaSep: a resource of RNAs undergoing phase separation Open
Liquid-liquid phase separation (LLPS) partitions cellular contents, underlies the formation of membraneless organelles and plays essential biological roles. To date, most of the research on LLPS has focused on proteins, especially RNA-bind…
View article: <i>BRAF</i> V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer
<i>BRAF</i> V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer Open
Context How lymph node metastasis (LNM)-associated mortality risk is affected by BRAF V600E in papillary thyroid cancer (PTC) remains undefined. Objective To study whether BRAF V600E affected LNM-associated mortality in PTC. Design, Settin…
View article: Therapeutic targeting of FOS in mutant <i>TERT</i> cancers through removing TERT suppression of apoptosis via regulating <i>survivin</i> and <i>TRAIL-R2</i>
Therapeutic targeting of FOS in mutant <i>TERT</i> cancers through removing TERT suppression of apoptosis via regulating <i>survivin</i> and <i>TRAIL-R2</i> Open
Significance Given that oncogenic hotspot mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) are common, it has been attractive to develop therapeutic strategies targeting TERT in mutant TERT human cancers. N…
View article: Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer Open
[This corrects the article DOI: 10.1371/journal.pone.0221093.].
View article: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer Open
Previous studies have documented an intrinsic association between breast cancer (BC) and thyroid cancer (TC), but the clinical relevance of this relationship is not well defined. In the present study, we specifically investigated the impac…
View article: The Genetic Duet of <i>BRAF</i> V600E and <i>TERT</i> Promoter Mutations Robustly Predicts Loss of Radioiodine Avidity in Recurrent Papillary Thyroid Cancer
The Genetic Duet of <i>BRAF</i> V600E and <i>TERT</i> Promoter Mutations Robustly Predicts Loss of Radioiodine Avidity in Recurrent Papillary Thyroid Cancer Open
BRAF V600E and TERT promoter mutations, particularly their genetic duet, are well known to be associated with poor clinical outcomes of papillary thyroid cancer (PTC). Loss of radioactive iodine (RAI) avidity in recurrent PTC is a major ca…
View article: Stage II Differentiated Thyroid Cancer Is a High-Risk Disease in Patients &lt;45/55 Years Old
Stage II Differentiated Thyroid Cancer Is a High-Risk Disease in Patients <45/55 Years Old Open
Purpose The mortality risk of stage II differentiated thyroid cancer (DTC) based on the American Joint Committee on Cancer (AJCC) staging system requires further investigation. Methods Retrospective study of DTC in the US Surveillance, Epi…
View article: <i>BRAF</i> V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer
<i>BRAF</i> V600E Confers Male Sex Disease-Specific Mortality Risk in Patients With Papillary Thyroid Cancer Open
Purpose To test whether the prognostic risk of male sex in papillary thyroid cancer (PTC) is determined by BRAF V600E and can thus be stratified by BRAF status. Patients and Methods We retrospectively investigated the relationship between …
View article: Patient Age–Associated Mortality Risk Is Differentiated by <i>BRAF</i> V600E Status in Papillary Thyroid Cancer
Patient Age–Associated Mortality Risk Is Differentiated by <i>BRAF</i> V600E Status in Papillary Thyroid Cancer Open
Purpose For the past 65 years, patient age at diagnosis has been widely used as a major mortality risk factor in the risk stratification of papillary thyroid cancer (PTC), but whether this is generally applicable, particularly in patients …
View article: BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment
BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment Open
Background Precise risk stratification-based treatment of solitary intrathyroidal papillary thyroid cancer (SI-PTC) that is larger than 1.0 cm and 4.0 cm or less is undefined. Methods A genetic-clinical risk study was performed on BRAF V60…
View article: The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer
The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer Open
Tumor multifocality has no independent risk prognostic value in clinical outcomes of PTC; its indiscriminate use as an independent risk factor, prompting overtreatments of patients, should be avoided.