Explanipedia

Longitudinal, simultaneous wide-field fluorescent Ca <sup>2+</sup> imaging and fMRI in awake mice Open

Francesca Mandino, Tae‐Weon Kang, Xilin Shen, Corey Horien, Xenophon Papademetris , et al. · 2025

Functional magnetic resonance imaging (fMRI) can be applied in mice and humans making it a key technology in translational neuroimaging research. Yet, most neuroimaging studies in rodents use anesthesia to limit subject motion and stress. …

Is the whole more than the sum of its parts? Considering global and local features of the connectome improves prediction of individuals and phenotypes Open

S. J. Riley, Annie Cheng, Yuwei Wang, Xilin Shen, Yize Zhao , et al. · 2025

Popular methods for analyzing the brain’s functional connectome examine statistical associations between pairs of atlas-defined brain regions, viewing the strength of these links as independent values. However, edges within a standard conn…

Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships Open

Alexander J. Simon, Anja Samardzija, Santino Iannone, Fernando Rodríguez, Saloni Mehta , et al. · 2025

Connectome-based predictive modeling (CPM) applied to functional MRI connectivity data can identify brain networks that vary with behavioral measures across subjects. The prediction strength also provides an index of how closely an externa…

Tau-Connectome Subtypes and Solanezumab Response in Preclinical Alzheimer’s Disease Open

Hamid Abuwarda, Wen‐Xiang Tsai, Shengxian Ding, M. Elhassan, Xilin Shen , et al. · 2025

Importance This study identifies clinically meaningful subtypes within preclinical Alzheimer’s disease (AD) using the functional connectome and introduces tau-predictive functional connectivity as a new tool to stratify risk and treatment …

A Transdiagnostic fMRI Dataset With 300+ Deeply Phenotyped Subjects Across Resting and Task States. Open

Anja Samardzija, Xilin Shen, Abigail S. Greene, Saloni Mehta, Santino Iannone , et al. · 2025

YaleNeuroConnect is a human functional MRI (fMRI) dataset collected at Yale University that includes functional MRI data (and the respective functional connectomes) obtained under resting-state and six task conditions. There are 302 diagno…

Exploring the diagnostic and prognostic utility of resting state functional MRI connectivity in acute/sub-acute TBI Open

Mariya Chepisheva, Xilin Shen, Cheryl Lacadie, Wendy Luo, J. Appleton , et al. · 2025

Traumatic brain injury (TBI) is a leading cause of disability worldwide. Yet, our understanding of the mechanisms of this condition is limited, especially in the acute setting. Here, we investigated the relationship between functional conn…

Multimodal identification of the mouse brain using simultaneous Ca2+ imaging and fMRI Open

Francesca Mandino, Corey Horien, Xilin Shen, Gabriel Desrosiers-Grégoire, Wendy Luo , et al. · 2025

Individual differences in neuroimaging are of interest to clinical and cognitive neuroscientists based on their potential for guiding the personalized treatment of various heterogeneous neurological conditions and diseases. Despite many ad…

PREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES Open

Anjali Sankar, Xilin Shen, Lejla Čolić, Danielle A. Goldman, Luca M. Villa , et al. · 2025

Background Depressed and elevated mood symptom severity underlie the suffering associated with bipolar disorder and are among the strongest clinical predictors of functional impairment and disability in the disorder. Furthermore, mood symp…

Geometric influences on the regional organization of the mammalian brain Open

James C. Pang, Peter A. Robinson, Kevin Aquino, Priscila T. Levi, Alexander Holmes , et al. · 2025

The mammalian brain is comprised of anatomically and functionally distinct regions. Substantial work over the past century has pursued the generation of ever-more accurate maps of regional boundaries, using either expert judgement or data-…

Do in-scanner tasks outperform rest for predicting autistic traits using functional connectivity data? Open

Corey Horien, Francesca Mandino, Abigail S. Greene, Xilin Shen, Kelly Powell , et al. · 2025

Autism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates of autistic features. Nevertheless, little work has focused on the optimal brain states …

Graph-Patchformer: Patch Interaction Transformer with Adaptive Graph Learning for Multivariate Time Series Forecasting Open

Chunyi Hou, Yongchuan Yu, Jinquan Ji, Siyao Zhang, Xilin Shen , et al. · 2025

Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease Open

Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Sophia Moret , et al. · 2025

Preclinical Alzheimer’s disease, characterized by the abnormal accumulation of amyloid-β prior to cognitive symptoms, presents a critical opportunity for early intervention. Past work has described functional connectivity (FC) changes in p…

Supervised brain node and network construction under voxel-level functional imaging Open

Wanwan Xu, Selena Wang, Shangbing Gao, Xinyuan Tian, Chichun Tan , et al. · 2025

Recent advancements in understanding the brain’s functional organization related to behavior have been pivotal, particularly in the development of predictive models based on brain connectivity. A major analytical strategy in this domain in…

Aging-dependent loss of functional connectivity in a mouse model of Alzheimer’s disease and reversal by mGluR5 modulator Open

Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Grégoire, David O’Connor, Bandhan Mukherjee , et al. · 2024

Amyloid accumulation in Alzheimer's disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of amyloid accumulation and biochemical changes in mouse models have utility for translational s…

Supervised brain node and network construction under voxel-level functional imaging Open

Wanwan Xu, Selena Wang, Chichun Tan, Xilin Shen, Wenjing Luo , et al. · 2024

Recent advancements in understanding the brain's functional organization related to behavior have been pivotal, particularly in the development of predictive models based on brain connectivity. Traditional methods in this domain often invo…

Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity Open

Marija Markicevic, Francesca Mandino, Takuya Toyonaga, Zhengxin Cai, Arman Fesharaki‐Zadeh , et al. · 2024

Repeated mild head injuries due to sports, or domestic violence and military service are increasingly linked to debilitating symptoms in the long term. Although symptoms may take decades to manifest, potentially treatable neurobiological a…

Multimodal identification of the mouse brain using simultaneous Ca<sup>2+</sup>imaging and fMRI Open

Francesca Mandino, Corey Horien, Xilin Shen, Gabriel Desrosiers-Grégoire, Wendy Luo , et al. · 2024

Individual differences in neuroimaging are of interest to clinical and cognitive neuroscientists based on their potential for guiding the personalized treatment of various heterogeneous neurological conditions and diseases. Despite many ad…

Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer’s disease Open

Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Suyeon Ju , et al. · 2024

Preclinical Alzheimer’s disease (AD), characterized by the abnormal accumulation of amyloid prior to cognitive symptoms, presents a critical opportunity for early intervention. Past work has described functional connectivity changes in pre…

Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization Open

Hadi Vafaii, Francesca Mandino, Gabriel Desrosiers-Grégoire, David O’Connor, Marija Markicevic , et al. · 2024

Large-scale functional networks have been characterized in both rodent and human brains, typically by analyzing fMRI-BOLD signals. However, the relationship between fMRI-BOLD and underlying neural activity is complex and incompletely under…

SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability Open

Matthew O’Brien, Marina V. Pryzhkova, Evelyn Lake, Francesca Mandino, Xilin Shen , et al. · 2023

Up to 50% of patients with severe congenital heart disease (CHD) develop life-altering neurodevelopmental disability (NDD). It has been presumed that NDD arises in CHD cases because of hypoxia before, during, or after cardiac surgery. Rece…

Aging-Dependent Loss of Connectivity in Alzheimer’s Model Mice with Rescue by mGluR5 Modulator Open

Francesca Mandino, Xilin Shen, Gabriel Desrosiers-Grégoire, David O’Connor, Bandhan Mukherjee , et al. · 2023

Amyloid accumulation in Alzheimer’s disease (AD) is associated with synaptic damage and altered connectivity in brain networks. While measures of amyloid accumulation and biochemical changes in mouse models have utility for translational s…

Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance Open

Suyeon Ju, Corey Horien, Xilin Shen, Hamid Abuwarda, Anne Trainer , et al. · 2023

Alzheimer's disease (AD) takes a more aggressive course in women than men, with higher prevalence and faster progression. Amnestic AD specifically targets the default mode network (DMN), which subserves short-term memory; past research sho…

Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes Open

Anjali Sankar, Xilin Shen, Lejla Čolić, Danielle A. Goldman, Luca M. Villa , et al. · 2023

Background The study is aimed to identify brain functional connectomes predictive of depressed and elevated mood symptomatology in individuals with bipolar disorder (BD) using the machine learning approach Connectome-based Predictive Model…

Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance Open

Suyeon Ju, Corey Horien, Xilin Shen, Hamid Abuwarda, Anne Trainer , et al. · 2022

Alzheimer’s disease (AD) takes a more aggressive course in women than men, with higher prevalence and faster progression. Amnestic AD specifically targets the default mode network (DMN), which subserves short-term memory; past research sho…

Multimodal measures of spontaneous brain activity reveals both common and divergent patterns of cortical functional organization Open

Hadi Vafaii, Francesca Mandino, Gabriel Desrosiers-Grégoire, David O’Connor, Xilin Shen , et al. · 2022

Work in humans and animals shows that the brain can be decomposed into large-scale functional networks. Whereas most studies, especially in humans, use the blood-oxygenation-level-dependent (BOLD) signal, the relationship between BOLD and …

A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth Open

Corey Horien, Abigail S. Greene, Xilin Shen, Diogo Fortes, Emma Brennan‐Wydra , et al. · 2022

Difficulty with attention is an important symptom in many conditions in psychiatry, including neurodiverse conditions such as autism. There is a need to better understand the neurobiological correlates of attention and leverage these findi…

Sex differences in default mode network connectivity in healthy aging adults Open

Bronte Ficek, Corey Horien, Suyeon Ju, Wanwan Xu, Nancy Li , et al. · 2022

Women show an increased lifetime risk of Alzheimer’s disease (AD) compared with men. Characteristic brain connectivity changes, particularly within the default mode network (DMN), have been associated with both symptomatic and preclinical …

Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type Open

David O’Connor, Francesca Mandino, Xilin Shen, Corey Horien, Xinxin Ge , et al. · 2022

To improve 'bench-to-bedside' translation, it is integral that knowledge flows bidirectionally-from animal models to humans, and vice versa. This requires common analytical frameworks, as well as open software and data sharing practices. W…

Brain–phenotype models fail for individuals who defy sample stereotypes Open

Abigail S. Greene, Xilin Shen, Stephanie Noble, Corey Horien, Changtae Hahn , et al. · 2022

Individual differences in brain functional organization track a range of traits, symptoms and behaviours 1–12 . So far, work modelling linear brain–phenotype relationships has assumed that a single such relationship generalizes across all …

A generalizable connectome-based marker of in-scan sustained attention in neurodiverse youth Open

Corey Horien, Abigail S. Greene, Xilin Shen, Diogo Fortes, Emma Brennan‐Wydra , et al. · 2022

Difficulty with attention is an important symptom in many conditions in psychiatry, including neurodiverse conditions such as autism. There is a need to better understand the neurobiological correlates of attention and leverage these findi…

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