Xiling Li
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View article: Non-targeted and chiral amino acid metabolomics of colon cancer: Revealing novel chiral biomarkers and metabolic pathways
Non-targeted and chiral amino acid metabolomics of colon cancer: Revealing novel chiral biomarkers and metabolic pathways Open
View article: Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method
Screening of glycan biomarkers for early detection of colorectal cancer based on novel isotope labeling relative quantitative method Open
View article: Distinct input-specific mechanisms enable presynaptic homeostatic plasticity
Distinct input-specific mechanisms enable presynaptic homeostatic plasticity Open
Synapses are endowed with the flexibility to change through experience, but must be sufficiently stable to last a lifetime. This tension is illustrated at the Drosophila neuromuscular junction (NMJ), where two motor inputs that differ in s…
View article: The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis
The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis Open
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit…
View article: Direct analysis of blood concentration and pharmacokinetics of active constituents of Xuebijing injection in rats using miniature mass spectrometry
Direct analysis of blood concentration and pharmacokinetics of active constituents of Xuebijing injection in rats using miniature mass spectrometry Open
The study of pharmacokinetics of traditional Chinese medicine (TCM) is closely related to its efficacy and safety. Mass spectrometry (MS)-based techniques play a crucial role in the research of TCM pharmacokinetics. However, there are few …
View article: Distinct input-specific mechanisms enable presynaptic homeostatic plasticity
Distinct input-specific mechanisms enable presynaptic homeostatic plasticity Open
Synapses are endowed with the flexibility to change through experience, but must be sufficiently stable to last a lifetime. This tension is illustrated at the Drosophila neuromuscular junction (NMJ), where two motor inputs that differ in s…
View article: Retrospective cohort study of neonatal blood transfusion in China
Retrospective cohort study of neonatal blood transfusion in China Open
Background Blood transfusion therapy is extremely important for certain neonatal diseases, but the threshold for neonatal blood transfusion is not the same in different countries. Until now, clinical studies to determine the suitable thres…
View article: Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons
Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons Open
Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity patterns, with some neurons firing at a relatively const…
View article: Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons
Physiologic and nanoscale distinctions define glutamatergic synapses in tonic vs phasic neurons Open
Neurons exhibit a striking degree of functional diversity, each one tuned to the needs of the circuitry in which it is embedded. A fundamental functional dichotomy occurs in activity patterns, with some neurons firing at a relatively const…
View article: Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly
Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly Open
View article: Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression
Autocrine inhibition by a glutamate-gated chloride channel mediates presynaptic homeostatic depression Open
An adaptive mechanism couples excess glutamate release to an activity-dependent anionic conductance at presynaptic terminals.
View article: Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis
Potential use of a dried saliva spot (DSS) in therapeutic drug monitoring and disease diagnosis Open
View article: Retrospective Cohort Study of Neonatal Blood Transfusion in China
Retrospective Cohort Study of Neonatal Blood Transfusion in China Open
Background: Blood transfusion treatment is extremely important for newborns，but the threshold of neonatal blood transfusion is not same in different countries, which may be due to differences in regions, races and nationalities, as well as…
View article: Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons
Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons Open
To develop effective cures for neuromuscular diseases, human-relevant in vitro models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture mo…
View article: The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation
The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation Open
Significance Physiological signals that modulate glutamate receptor trafficking and function remain enigmatic. Here, we identify the auxiliary glutamate receptor subunit dSol-1 to be necessary for the homeostatic control of presynaptic neu…
View article: Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments
Distinct Target-Specific Mechanisms Homeostatically Stabilize Transmission at Pre- and Post-synaptic Compartments Open
Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation …
View article: Distinct target-specific mechanisms homeostatically stabilize transmission at pre-and post-synaptic compartments
Distinct target-specific mechanisms homeostatically stabilize transmission at pre-and post-synaptic compartments Open
Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At Drosophila neuromuscular junctions, synaptic strength remains stable in a manipulation that simultane…
View article: Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling Open
View article: The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis
The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis Open
Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit…
View article: Estimation of the Readily Releasable Synaptic Vesicle Pool at the Drosophila Larval Neuromuscular Junction
Estimation of the Readily Releasable Synaptic Vesicle Pool at the Drosophila Larval Neuromuscular Junction Open
Presynaptic boutons at nerve terminals are densely packed with synaptic vesicles, specialized organelles for rapid and regulated neurotransmitter secretion. Upon depolarization of the nerve terminal, synaptic vesicles fuse at specializatio…
View article: The sleep gene <i>insomniac</i> ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling
The sleep gene <i>insomniac</i> ubiquitinates targets at postsynaptic densities and is required for retrograde homeostatic signaling Open
The nervous system confronts challenges during development and experience that can destabilize information processing. To adapt to these perturbations, synapses homeostatically adjust synaptic strength, a process referred to as homeostatic…
View article: A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release
A Glutamate Homeostat Controls the Presynaptic Inhibition of Neurotransmitter Release Open
We have interrogated the synaptic dialog that enables the bi-directional, homeostatic control of presynaptic efficacy at the glutamatergic Drosophila neuromuscular junction (NMJ). We find that homeostatic depression and potentiation use di…
View article: Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation
Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation Open
Postsynaptic compartments can be specifically modulated during various forms of synaptic plasticity, but it is unclear whether this precision is shared at presynaptic terminals. Presynaptic homeostatic plasticity (PHP) stabilizes neurotran…
View article: Author response: Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation
Author response: Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Postsynaptic compartments can be specifically m…
View article: Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy
Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy Open
Retrograde signaling systems are fundamental modes of communication synapses utilize to dynamically and adaptively modulate activity. However, the inductive mechanisms that gate retrograde communication in the postsynaptic compartment rema…
View article: Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in <i>Drosophila</i>
Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in <i>Drosophila</i> Open
In highly polarized neurons, an extensive endoplasmic reticulum (ER) network extends to distal dendrites and axons. Several human diseases result from... The endoplasmic reticulum (ER) is an extensive organelle in neurons with important ro…
View article: Extended Synaptotagmin is a presynaptic ER Ca<sup>2+</sup>sensor that promotes neurotransmission and synaptic growth in<i>Drosophila</i>
Extended Synaptotagmin is a presynaptic ER Ca<sup>2+</sup>sensor that promotes neurotransmission and synaptic growth in<i>Drosophila</i> Open
The endoplasmic reticulum (ER) is an extensive presynaptic organelle, exerting important influences at synapses by responding to Ca 2+ and modulating transmission, growth, lipid metabolism, and membrane trafficking. Despite intriguing evid…
View article: The<i>Drosophila</i>Postsynaptic DEG/ENaC Channel<i>ppk29</i>Contributes to Excitatory Neurotransmission
The<i>Drosophila</i>Postsynaptic DEG/ENaC Channel<i>ppk29</i>Contributes to Excitatory Neurotransmission Open
The protein family of degenerin/epithelial sodium channels (DEG/ENaCs) is composed of diverse animal-specific, non-voltage-gated ion channels that play important roles in regulating cationic gradients across epithelial barriers. Some famil…