Xianghua Huang
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View article: A biomimetic bilayer fibrous scaffold for repair of massive rotator cuff tear via minimally invasive delivery
A biomimetic bilayer fibrous scaffold for repair of massive rotator cuff tear via minimally invasive delivery Open
Therapeutic arthroscopy is a common minimally invasive procedure, yet repairing massive rotator cuff tears remains challenging due to difficulties in delivering patches and replicating the complex tendon–bone interface. Herein, a clinical …
View article: Causes of drug-induced photosensitivity: an analysis using FDA adverse event reporting system database
Causes of drug-induced photosensitivity: an analysis using FDA adverse event reporting system database Open
The purpose of this study is to analyze FAERS data to identify cases of drug-induced photosensitivity (DIP), examine demographic patterns, determine the drug classes involved, and highlight emerging trends in these reactions. Additionally,…
View article: WITHDRAWN: From myometrium to fibrosis: the underlying mechanism of endometrial injury in intrauterine adhesions
WITHDRAWN: From myometrium to fibrosis: the underlying mechanism of endometrial injury in intrauterine adhesions Open
The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corr…
View article: A Multicenter Cohort Study on <scp>DNA</scp> Methylation for Endometrial Cancer Detection in Cervical Scrapings
A Multicenter Cohort Study on <span>DNA</span> Methylation for Endometrial Cancer Detection in Cervical Scrapings Open
Background The increasing incidence of endometrial cancer (EC) has highlighted the need for improved early detection methods. This study aimed to develop and validate a novel DNA methylation classifier, EMPap, for EC detection using cervic…
View article: WITHDRAWN: From myometrium to fibrosis: the underlying mechanism of endometrial injury in intrauterine adhesions
WITHDRAWN: From myometrium to fibrosis: the underlying mechanism of endometrial injury in intrauterine adhesions Open
Our previous research revealed myometrium is closely related to the occurrence and regeneration of endometrial injury. This study aims to explore potential pathways of endometrial injury in intrauterine adhesions (IUA). Histological, trans…
View article: A rare case report of Herlyn-Werner-Wunderlich syndrome: Unraveling unusual urinary anomalies and literature review
A rare case report of Herlyn-Werner-Wunderlich syndrome: Unraveling unusual urinary anomalies and literature review Open
Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital genitourinary abnormality defined by uterine didelphys, obstructed hemivagina, and ipsilateral urological anomalies. Accurate diagnosis and prompt commencement of therapy can be…
View article: Clinical Efficacy of Modified Nonmesh Sacral Colpopexy for Pelvic Organ Prolapse
Clinical Efficacy of Modified Nonmesh Sacral Colpopexy for Pelvic Organ Prolapse Open
Importance As an increasing number of mesh-related complications have been reported, the availability of nonmesh alternatives becomes crucial for situations where mesh is not desired or unavailable. A new modified procedure of nonmesh lapa…
View article: ATRX is a predictive marker for endocrinotherapy and chemotherapy resistance in HER2-/HR+ breast cancer through the regulation of the AR, GLI3 and GATA2 transcriptional network
ATRX is a predictive marker for endocrinotherapy and chemotherapy resistance in HER2-/HR+ breast cancer through the regulation of the AR, GLI3 and GATA2 transcriptional network Open
Drug resistance in breast cancer (BC) is a clinical challenge. Exploring the mechanism and identifying a precise predictive biomarker for the drug resistance in BC is critical. Three first-line drug (paclitaxel, doxorubicin and tamoxifen) …
View article: Human umbilical cord mesenchymal stem cell‑derived exosomes improve ovarian function in natural aging by inhibiting apoptosis
Human umbilical cord mesenchymal stem cell‑derived exosomes improve ovarian function in natural aging by inhibiting apoptosis Open
Prolonging the reproductive lifespan is beneficial for preserving the physical and psychological health of women. The transplantation of mesenchymal stem cell (MSC)‑derived exosomes (MSC‑Exos) has been reported to be a promising regenerati…
View article: Desktop-stereolithography 3D printing of a decellularized extracellular matrix/mesenchymal stem cell exosome bioink for vaginal reconstruction
Desktop-stereolithography 3D printing of a decellularized extracellular matrix/mesenchymal stem cell exosome bioink for vaginal reconstruction Open
Abstarct Background 3D-printing is widely used in regenerative medicine and is expected to achieve vaginal morphological restoration and true functional reconstruction.Mesenchymal stem cells-derived exosomes (MSCs-Exos) were applyed in the…
View article: Maternal Preoperative Hemoglobin Level and Risk of Intraoperative Massive Hemorrhage in Placenta Accrete Spectrum Disorders: A Cross-Sectional Study
Maternal Preoperative Hemoglobin Level and Risk of Intraoperative Massive Hemorrhage in Placenta Accrete Spectrum Disorders: A Cross-Sectional Study Open
BACKGROUND Placenta accreta spectrum (PAS) disorders involve abnormal adhesion or invasion of chorionic villi through the myometrium and uterine serosa. Maternal anemia during pregnancy is common and may contribute to complications during …
View article: Small intestinal submucosa promotes angiogenesis via the Hippo pathway to improve vaginal repair
Small intestinal submucosa promotes angiogenesis via the Hippo pathway to improve vaginal repair Open
Vaginal reconstruction has incorporated the use of gastrointestinal segments for decades, but the technique is inevitably associated with complications. Tissue-engineering techniques, however, have brought great hope for vaginal reconstruc…
View article: Supplementary Material for: Rapid initiation of peritoneal dialysis by automated peritoneal dialysis or hemodialysis: a randomized clinical trial
Supplementary Material for: Rapid initiation of peritoneal dialysis by automated peritoneal dialysis or hemodialysis: a randomized clinical trial Open
Introduction: It is still controversial whether automated peritoneal dialysis (APD) or hemodialysis (HD) is a more favorable choice for the rapid initiation of peritoneal dialysis. Methods: A pilot randomized prospective controlled trial w…
View article: Ovarian pregnancy after bilateral salpingectomy in a patient with <i>in vitro</i> fertilization: a case report
Ovarian pregnancy after bilateral salpingectomy in a patient with <i>in vitro</i> fertilization: a case report Open
Ovarian pregnancy is rare but may occur with in vitro fertilization-embryo transfer in women who have undergone bilateral salpingectomy. We report a case of an approximately 30-year-old woman who had in vitro fertilization and a history of…
View article: Effects of LPA on the development of sheep in vitro fertilized embryos and attempt to establish sheep embryonic stem cells
Effects of LPA on the development of sheep in vitro fertilized embryos and attempt to establish sheep embryonic stem cells Open
Lysophosphatidic acid (LPA) is a small molecule glycerophospholipid, which regulates multiple downstream signalling pathways through G-protein-coupled receptors to achieve numerous functions on oocyte maturation and embryo development. In …
View article: Ovary-derived Decellularized Extracellular Matrix-based Bioink for Fabricating 3D Primary Ovarian Cells-laden Structures for Mouse Ovarian Failure Correction
Ovary-derived Decellularized Extracellular Matrix-based Bioink for Fabricating 3D Primary Ovarian Cells-laden Structures for Mouse Ovarian Failure Correction Open
Fertility preservation is becoming a clinical duty in practice. Three-dimensional (3D) bioprinting technology is potentially realize ovarian morphological repair and reproductive endocrine function rebuild. There is no published work on 3D…
View article: Drug-free in vitro activation combined 3D-bioprinted adipose-derived stem cells restore ovarian function of premature ovarian insufficiency
Drug-free in vitro activation combined 3D-bioprinted adipose-derived stem cells restore ovarian function of premature ovarian insufficiency Open
Background Emerging drug-free in vitro activation (IVA) technique enables patients with premature ovarian insufficiency (POI) to restore ovarian function and conceive their own genetic offspring. However, many issues have greatly restricte…
View article: Anti-NMDA Receptor Encephalitis: Retrospective Analysis of 15 Cases, Literature Review, and Implications for Gynecologists
Anti-NMDA Receptor Encephalitis: Retrospective Analysis of 15 Cases, Literature Review, and Implications for Gynecologists Open
Background. Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare form of autoimmune encephalitis caused by anti-NMDA receptor antibodies. This disease mainly affects women of childbearing age and is commonly associated with ova…
View article: Dysregulated miR-222-3p in plasma exosomes of preeclampsia patients and its <i>In vitro</i> effect on HTR8/SVneo extravillous trophoblast cells by targeting STMN1
Dysregulated miR-222-3p in plasma exosomes of preeclampsia patients and its <i>In vitro</i> effect on HTR8/SVneo extravillous trophoblast cells by targeting STMN1 Open
Objective To investigate the diagnostic efficiency of miR-222–3p in plasma exosomes (Exos) and plasma for preeclampsia (PE) and the effect of miR-222–3p targeting STMN1 in PE Methods MiR-222–3p levels in total plasma and plasma Exos were d…
View article: Analysis of Dynamic Characteristics for Machine Tools Based on Dynamic Stiffness Sensitivity
Analysis of Dynamic Characteristics for Machine Tools Based on Dynamic Stiffness Sensitivity Open
Dynamic parameters are the intermediate information of the entirety of machine dynamics. The differences between components have not been combined with the structural vibration in the cutting process, so it is difficult to directly represe…