Ximo Wang
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View article: The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer
The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer Open
Colorectal cancer (CRC) progression is regulated by an immunosuppressive tumor microenvironment, but the epigenetic mechanisms governing this milieu remain unclear. This study identifies the histone demethylase KDM6B as a key regulator of …
View article: Tryptophan metabolism in pancreatic cancer: A review
Tryptophan metabolism in pancreatic cancer: A review Open
Our study provides a detailed exploration of the role of tryptophan metabolism in pancreatic cancer, including its normal function, the impact of targeted drugs, and the influence of gut microbiota on metabolism. Additionally, the article …
View article: LRP1B in cancer: From a mutation landscape to predictive biomarkers for precision oncology
LRP1B in cancer: From a mutation landscape to predictive biomarkers for precision oncology Open
Low-density lipoprotein receptor-related protein 1B (LRP1B) is one of the most frequently mutated genes across a wide range of malignancies and has garnered increasing attention owing to its crucial role in tumorigenesis and clinical outco…
View article: Current status and progress of diagnosis and treatment of postoperative recurrence of gastrointestinal peritoneal metastases
Current status and progress of diagnosis and treatment of postoperative recurrence of gastrointestinal peritoneal metastases Open
The peritoneum is a frequently involved site of metastasis in gastrointestinal malignancies, posing a major risk to human health. In recent years, treatment methods such as cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemo…
View article: Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study
Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study Open
The Xuanfei Baidu Decoction (XFBD) has shown effective therapeutic potential for acute lung injury (ALI) induced by lipopolysaccharide and immunoglobin G immune complexes. Herein, the protective effects and mechanisms of XFBD were investig…
View article: Analysis of cullin family genes in rectal adenocarcinoma: expression, prognostic significance, and therapeutic implications
Analysis of cullin family genes in rectal adenocarcinoma: expression, prognostic significance, and therapeutic implications Open
This study provides novel insight into the role of cullin genes in READ, suggesting that CUL2 and CUL7 may be biomarkers and therapeutic targets. Further research is warranted to explore their underlying mechanisms and clinical application…
View article: Comparative bibliometric analysis of artificial intelligence-assisted polyp diagnosis and AI-assisted digestive endoscopy: trends and growth in AI gastroenterology (2003–2023)
Comparative bibliometric analysis of artificial intelligence-assisted polyp diagnosis and AI-assisted digestive endoscopy: trends and growth in AI gastroenterology (2003–2023) Open
Introduction Artificial intelligence is already widely utilized in gastroenterology. This study aims to comprehensively evaluate the research hotspots and development trends within the field of AI in gastroenterology by employing bibliomet…
View article: KDM6B enhances anti-PD-L1 immunotherapy efficacy by increasing CD8+ T-cell infiltration in colorectal cancer
KDM6B enhances anti-PD-L1 immunotherapy efficacy by increasing CD8+ T-cell infiltration in colorectal cancer Open
Background: CD8+ T cells in the tumor microenvironment are crucial for antitumor effects. Boosting their infiltration can significantly enhance the efficacy of antitumor immunotherapy. However, the precise contribution of the epigenetic re…
View article: RGS1 targeted by miR-191-3p inhibited the stemness properties of esophageal cancer cells by suppressing CXCR4/PI3K/AKT signaling
RGS1 targeted by miR-191-3p inhibited the stemness properties of esophageal cancer cells by suppressing CXCR4/PI3K/AKT signaling Open
Background: Esophageal cancer is one of the most common malignant tumors in the world. It is urgent to prevent the development and progression of esophageal cancer. Cancer stem cells (CSCs) were reported to have the ability to initiate tum…
View article: Prediction of Diabetic Macular Edema Using Knowledge Graph
Prediction of Diabetic Macular Edema Using Knowledge Graph Open
Diabetic macular edema (DME) is a significant complication of diabetes that impacts the eye and is a primary contributor to vision loss in individuals with diabetes. Early control of the related risk factors is crucial to reduce the incide…
View article: A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection
A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection Open
Objective To construct a reliable nomogram available online to predict the postoperative survival of patients with perihilar cholangiocarcinoma. Methods Data from 1808 patients diagnosed with perihilar cholangiocarcinoma between 2004 and 2…
View article: Targeting <scp>PYCR2</scp> inhibits intraperitoneal metastatic tumors of mouse colorectal cancer in a proline‐independent approach
Targeting <span>PYCR2</span> inhibits intraperitoneal metastatic tumors of mouse colorectal cancer in a proline‐independent approach Open
Whether proline deficiency is a metabolic vulnerability in colorectal tumors is unknown. The aim of this study was to investigate the effects of proline metabolism‐related genes and exogenous proline on the progression of colorectal cancer…
View article: A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection
A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection Open
Objective To construct a nomogram that can predict the survival rate of patients with perihilar cholangiocarcinoma.Methods Data from 1808 patients diagnosed with perihilar cholangiocarcinoma between 2004 and 2015 were extracted from the Na…
View article: Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients
Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients Open
Background Colon adenocarcinoma (COAD) is a highly heterogeneous disease, thus making prognostic predictions uniquely challenging. Metabolic reprogramming is emerging as a novel cancer hallmark that may serve as the basis for more effectiv…
View article: Combined Detection of RUNX3 and EZH2 in Evaluating Efficacy of Neoadjuvant Therapy and Prognostic Value of Middle and Low Locally Advanced Rectal Cancer
Combined Detection of RUNX3 and EZH2 in Evaluating Efficacy of Neoadjuvant Therapy and Prognostic Value of Middle and Low Locally Advanced Rectal Cancer Open
Objective This article investigated whether Runt-Related Transcription Factor 3 (RUNX3) and enhancer of zeste homolog 2 (EZH2) can be used to evaluate the clinical efficacy of neoadjuvant therapy and prognosis of locally advanced rectal ca…
View article: Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model
Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model Open
The objective was to study the effect of mechanical intestinal obstruction in rats on the phenotype of interstitial cells of Cajal (ICC). Healthy Wistar rats were randomly divided into sham-operation group (C), one day obstruction group (M…
View article: Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice With Orthotopic Pancreatic Tumor
Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice With Orthotopic Pancreatic Tumor Open
The poor immunotherapy of pancreatic cancer is mainly due to its complex immunosuppressive microenvironment. The Mediterranean diet contributes to low cancer incidence. Hydroxytyrosol (HT) derived from olive oil has multiple health-promoti…
View article: Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling
Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling Open
Our study is the first to confirm the antitumor and autophagy-activating effects of oridonin on PC cells. In light of these results, oridonin may be a promising therapeutic agent for PC.
View article: Polyethyleneimine-impregnated alkali treated waste bamboo powder for effective dye removal
Polyethyleneimine-impregnated alkali treated waste bamboo powder for effective dye removal Open
In this study, the polyethyleneimine (PEI) modified waste bamboo powder (WBP-Na-PEI) was successfully prepared and applied to adsorbing Congo red (CR) dye from aqueous solution. The obtained materials were characterized by field emission s…
View article: Higher Serum Uric Acid Level Predicts Non-alcoholic Fatty Liver Disease: A 4-Year Prospective Cohort Study
Higher Serum Uric Acid Level Predicts Non-alcoholic Fatty Liver Disease: A 4-Year Prospective Cohort Study Open
Background: Non-alcoholic fatty liver disease (NAFLD) has become a serious disease affecting people's health in the world. This article studies the causal relationship between NAFLD and serum uric acid (SUA) levels. Methods: During the 4 y…
View article: Optimization of the process for purifying icariin from Herba Epimedii by macroporous resin and the regulatory role of icariin in the tumor immune microenvironment
Optimization of the process for purifying icariin from Herba Epimedii by macroporous resin and the regulatory role of icariin in the tumor immune microenvironment Open
Pancreatic cancer is a digestive tract malignancy that poses a serious threat to human health. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to regulate the tumor…
View article: Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization
Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization Open
The bioactive phenylethanoid 3,4-dihydroxyphenylethyl alcohol glycoside (DAG) is a component isolated from Sargentodoxa cuneata. The effects of DAG on acute lung injury (ALI) are largely unknown. Here, the effects of DAG on sepsis-induced …
View article: The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer
The role of 2-arachidonoylglycerol in the regulation of the tumor-immune microenvironment in murine models of pancreatic cancer Open
The pancreatic ductal adenocarcinoma (PDAC) microenvironment plays a critical role in the antitumor immune response. 2-arachidonoylglycerol (2-AG) exhibits a direct antitumor effect in various tumor models. However, the immunomodulatory ef…
View article: Efficacy and safety of once daily versus twice daily mesalazine for mild-to-moderate ulcerative colitis
Efficacy and safety of once daily versus twice daily mesalazine for mild-to-moderate ulcerative colitis Open
Background: We aimed to conduct a meta-analysis to evaluate the efficacy and safety between once daily (OD) and twice daily (BD) regime dosing of mesalazine for mild-to-moderate ulcerative colitis (UC). Methods: PubMed, Embase, the Cochran…
View article: Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model
Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model Open
The objective was to study the effect of mechanical intestinal obstruction in rats on the phenotype of interstitial cells of Cajal (ICC). Healthy Wistar rats were randomly divided into sham-operation group (C), one day obstruction group (M…