Xia Li
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View article: MAP3K1/MAP2K4 mutations drive breast cancer progression by compensating for TP53 loss through inactivation of the JNK2-p53-FOSL1 axis
MAP3K1/MAP2K4 mutations drive breast cancer progression by compensating for TP53 loss through inactivation of the JNK2-p53-FOSL1 axis Open
Our findings establish MAP3K1 and MAP2K4 as key tumor suppressors in BRCA that operate via the JNK2-p53-FOSL1 axis. Their inactivation provides an alternative mechanism for p53 pathway disruption, adhering to the "minimal necessary alterat…
View article: Elucidating Pancreatic Ductal Adenocarcinoma Carcinogenesis at Single-Cell Resolution and Identifying Subtype Specific Drug Candidates
Elucidating Pancreatic Ductal Adenocarcinoma Carcinogenesis at Single-Cell Resolution and Identifying Subtype Specific Drug Candidates Open
Although single-cell analyses have advanced our understanding of pancreatic ductal adenocarcinoma (PDAC), most studies to date have focused on primary and metastatic tumors. Here, we map cell composition, phenotypic plasticity, and microen…
View article: Multi−cohort validation based on coagulation-related genes for predicting prognosis of esophageal squamous cell carcinoma
Multi−cohort validation based on coagulation-related genes for predicting prognosis of esophageal squamous cell carcinoma Open
Objective In malignant tumors, a hypercoagulable state is frequently observed and is intricately intertwined with cancer development and the remodeling of the immune microenvironment. Recently, the coagulation-related genes (CRGs) signatur…
View article: Utilizing Minimal Physiologically Based Pharmacokinetic Modeling to Bridge Bevacizumab Pharmacokinetics from Adult to Pediatric Patients
Utilizing Minimal Physiologically Based Pharmacokinetic Modeling to Bridge Bevacizumab Pharmacokinetics from Adult to Pediatric Patients Open
Bevacizumab is a humanized monoclonal antibody (mAb) approved to treat various cancers in adults and was investigated in pediatric patients. While the drug development of small molecules in pediatrics has greatly benefited from the use of …
View article: Advanced dual primary male breast cancer and lung cancer: A case report and literature review
Advanced dual primary male breast cancer and lung cancer: A case report and literature review Open
The current report presents a unique case of advanced male invasive breast cancer coexisting with synchronous primary lung adenocarcinoma, a rare clinical manifestation. The case contributes to the limited literature on male breast cancer …
View article: Dissecting Melanoma Ecosystem Heterogeneity from Molecular Characteristics to Genetic Variation at Single-Cell Resolution
Dissecting Melanoma Ecosystem Heterogeneity from Molecular Characteristics to Genetic Variation at Single-Cell Resolution Open
Melanoma shows heterogeneity across body sites like skin, acral skin, and the uvea, driven by molecular characteristics and genetic variations. However, comparative studies exploring the heterogeneity of melanoma across different anatomica…
View article: Provably Mitigating Corruption, Overoptimization, and Verbosity Simultaneously in Offline and Online RLHF/DPO Alignment
Provably Mitigating Corruption, Overoptimization, and Verbosity Simultaneously in Offline and Online RLHF/DPO Alignment Open
Reinforcement learning from human feedback (RLHF) and direct preference optimization (DPO) are important techniques to align large language models (LLM) with human preference. However, the quality of RLHF and DPO training is seriously comp…
View article: Add-on ketogenic diet versus antiseizure medications alone in children with developmental and epileptic encephalopathies: a prospective comparative cohort study
Add-on ketogenic diet versus antiseizure medications alone in children with developmental and epileptic encephalopathies: a prospective comparative cohort study Open
Objective To compare the effectiveness and safety of ketogenic diet (KD) versus antiseizure medications (ASMs) adjustment in developmental and epileptic encephalopathy (DEE). Methods In this prospective, single-center cohort study, 268 par…
View article: Generative AI-Based Night Scene Design of Historic Districts: Value Transition from Basic Lighting to Cultural Narrative
Generative AI-Based Night Scene Design of Historic Districts: Value Transition from Basic Lighting to Cultural Narrative Open
As a cultural medium that facilitates the renewal and adaptive reuse of historic neighborhoods, nightscape design is undergoing an evolution from basic illumination to the conveyance of rich cultural narratives. The advent of generative ar…
View article: Comparative study of CO₂ nanobubbles and macrobubbles: Effects on water chemistry, microalgal growth, and carbon utilization
Comparative study of CO₂ nanobubbles and macrobubbles: Effects on water chemistry, microalgal growth, and carbon utilization Open
Algal biotechnology presents a cost-effective approach for simultaneous carbon dioxide (CO₂) capture and bioproduct generation. However, conventional gas delivery approaches (e.g., macro and micro-bubbles) suffer from low gas-liquid mass t…
View article: Expression of ORMDL1 in esophageal squamous cell carcinoma and its effect on patient outcomes: A potential biomarker and treatment target
Expression of ORMDL1 in esophageal squamous cell carcinoma and its effect on patient outcomes: A potential biomarker and treatment target Open
ORMDL1, a member of the ORMDL protein family, is an endoplasmic reticulum membrane protein. Abnormal expression of ORMDL1 in various types of human cancers has attracted much attention in recent years. However, the function of ORMDL1 in ES…
View article: Wrist-ankle acupuncture for preventing postoperative nausea and vomiting in high-risk female patients: study protocol for a pragmatic, randomized, single-blind, sham-controlled trial
Wrist-ankle acupuncture for preventing postoperative nausea and vomiting in high-risk female patients: study protocol for a pragmatic, randomized, single-blind, sham-controlled trial Open
Background Postoperative nausea and vomiting (PONV) affects approximately 30% of the general surgical population and up to 80% of high-risk patients, causing significant patient distress and dissatisfaction. Female gender, non-smoking stat…
View article: Macrophage Tim-4 protects against deep vein thrombosis by binding CK2β to suppress inflammatory responses
Macrophage Tim-4 protects against deep vein thrombosis by binding CK2β to suppress inflammatory responses Open
Background Deep vein thrombosis (DVT) is a venous reflux disorder caused by dysregulated coagulation, with macrophage inflammatory responses being critical for its progression. T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is…
View article: Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis
Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis Open
The intratumoral microbiota has been identified as an indispensable part of the tumor microenvironment (TME). However, the relationship between the intratumoral microbiota and host gene expression, as well as its impact on prognosis and TM…
View article: LimiX: Unleashing Structured-Data Modeling Capability for Generalist Intelligence
LimiX: Unleashing Structured-Data Modeling Capability for Generalist Intelligence Open
We argue that progress toward general intelligence requires complementary foundation models grounded in language, the physical world, and structured data. This report presents LimiX-16M and LimiX-2M, two instantiations of our large structu…
View article: Decoding coal-induced pulmonary endothelial injury using single-cell omics
Decoding coal-induced pulmonary endothelial injury using single-cell omics Open
Pulmonary endothelial injury is a critical factor in the pathogenesis and progression of coal pneumoconiosis. However, the precise mechanisms underlying this injury remain poorly understood. To address this, we established a coal pneumocon…
View article: S-glutathionylation modification of proteins and the association with cellular death (Review)
S-glutathionylation modification of proteins and the association with cellular death (Review) Open
S-glutathionylation (SSG), a redox-sensitive post-translational modification mediated by glutathione, regulates protein structure and function through reversible disulfide bond formation at cysteine residues. Glutaredoxins (GRXs), pivotal …
View article: Clinical experience of genome-wide non-invasive prenatal testing as a first-tier screening test in a cohort of 59,771 pregnancies
Clinical experience of genome-wide non-invasive prenatal testing as a first-tier screening test in a cohort of 59,771 pregnancies Open
Objective Genome-wide non-invasive prenatal testing (GW-NIPT) for prenatal screening has been widely implemented. However, the related clinical data is still insufficient. Here, we evaluated the clinical performance of GW-NIPT as a first-t…
View article: Ferroptosis-immune crosstalk in cervical cancer: mechanisms and therapeutic implications
Ferroptosis-immune crosstalk in cervical cancer: mechanisms and therapeutic implications Open
Cervical cancer remains a leading cause of cancer-related mortality in women worldwide, particularly in regions with limited access to screening and vaccination. While immunotherapy has shown promise in treating advanced cervical cancer, i…
View article: MAP3K1/MAP2K4 Mutations Drive Breast Cancer Progression by Compensating TP53 Loss via JNK2-p53-FOSL1 Axis Inactivation
MAP3K1/MAP2K4 Mutations Drive Breast Cancer Progression by Compensating TP53 Loss via JNK2-p53-FOSL1 Axis Inactivation Open
Background Breast cancer (BRCA) pathogenesis involves somatic mutations in key oncogenes and tumor suppressor genes, but the full spectrum of driver mutations and their functional impact remains incompletely understood. This study aimed to…
View article: Euglycemic diabetic ketoacidosis associated with etogliflozin in post-pancreatitis diabetes: A case report
Euglycemic diabetic ketoacidosis associated with etogliflozin in post-pancreatitis diabetes: A case report Open
BACKGROUND Sodium-glucose cotransporter-2 (SGLT-2) inhibitors improve cardiovascular and renal outcomes in diabetes but may induce euglycemic diabetic ketoacidosis (euDKA) via insulin-independent mechanisms. Post-pancreatitis diabetes mell…
View article: Progress of ketogenic diet in the treatment of developmental epileptic encephalopathy
Progress of ketogenic diet in the treatment of developmental epileptic encephalopathy Open
Developmental epileptic encephalopathy (DEE) is a severe neurological disorder caused by underlying genetic abnormalities and frequent epileptic activity. It is characterized by early-onset, drug-resistant epilepsy, abnormal electroencepha…