Yan Wang
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View article: Effects of excess bodyweight and flexible Flatfoot on female stance-phase lower-limb biomechanics assessed by statistical non-parametric mapping
Effects of excess bodyweight and flexible Flatfoot on female stance-phase lower-limb biomechanics assessed by statistical non-parametric mapping Open
This study investigated the effects of excessive body weight and flexible flatfoot (FFF) on gait patterns in females. Sixty participants were divided into four groups (overweight/obese or normal weight, each with either normal feet or FFF;…
View article: Multi‐Omics Decoding of <i>Dendrobium huoshanense</i> 's Dual‐Target Mechanism: Modulating Purine and Ether Lipid Metabolism for Type 2 Diabetes Therapy
Multi‐Omics Decoding of <i>Dendrobium huoshanense</i> 's Dual‐Target Mechanism: Modulating Purine and Ether Lipid Metabolism for Type 2 Diabetes Therapy Open
As a medicinal‐food homologous species, Dendrobium huoshanense (DH) exhibits promising antidiabetic properties; however, its underlying molecular mechanisms and bioactive components require further systematic investigation. This study inve…
View article: Association between triglyceride-glucose index and major adverse cardiovascular events in patients with intermediate coronary stenosis: a prospective cohort study
Association between triglyceride-glucose index and major adverse cardiovascular events in patients with intermediate coronary stenosis: a prospective cohort study Open
Objective This study aimed to evaluate the correlation between the triglyceride-glucose (TyG) index and the incidence of major adverse cardiovascular events (MACE) in patients with intermediate coronary stenosis. Methods and results A pros…
View article: Highly selective and AI-predictable Se–N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis
Highly selective and AI-predictable Se–N exchange chemistry between benzoselenazolones and boronic acids for programmable, parallel, and DNA-encoded library synthesis Open
An unprecedented chemo-selective and multi-orthogonal SeNEx chemistry is reported as a powerful tool for programmable synthesis, on-plate nanomole-scale parallel synthesis and DNA-encoded library synthesis, thus accelerating functional dis…
View article: Medical experience of family members of children in pediatric infusion room: a cross-sectional survey
Medical experience of family members of children in pediatric infusion room: a cross-sectional survey Open
Background Enhancing the medical experience of children and their family members constitutes a crucial component of clinical management. This study aims to analyze the current status of the medical experience among family members of childr…
View article: <scp>MiR</scp>‐20a‐5p Inhibits Bladder Cancer Proliferation and Migration by Targeting <scp>KPNA2</scp>
<span>MiR</span>‐20a‐5p Inhibits Bladder Cancer Proliferation and Migration by Targeting <span>KPNA2</span> Open
Bladder cancer (BC) is one of the 10 most common cancers in the world, and its recurrence and metastasis are the main causes of death in BC patients. Exploring the molecular mechanisms of BC pathogenesis and searching for new prognostic ma…
View article: A modelling framework to improve antibody titer estimation from dilution series data: application to RSV Foci Reduction Neutralization Tests
A modelling framework to improve antibody titer estimation from dilution series data: application to RSV Foci Reduction Neutralization Tests Open
Accurately determining antibody levels from experimental data is important for measuring population immunity, guiding vaccine development and informing public health policy. Based on raw dilution series data from respiratory syncytial viru…
View article: LIRTS Viewer: A Web-Based Resource to View the Transcriptional Response of Lens Epithelial Cells to Injury
LIRTS Viewer: A Web-Based Resource to View the Transcriptional Response of Lens Epithelial Cells to Injury Open
The LIRTS Viewer is useful for generating hypotheses related to PCO pathogenesis, as it reveals CAC gene expression dynamics, gene correlations, and biological pathways during the first 5 days following lens injury in an in vivo cataract s…
View article: The Application of Artificial Intelligence‐Based Bone Marrow Cell Analysis System in Pediatric Hematological Diseases
The Application of Artificial Intelligence‐Based Bone Marrow Cell Analysis System in Pediatric Hematological Diseases Open
Introduction The clinical diagnosis of hematological diseases depends on the differential count of nucleated cells on the bone marrow (BM) smears, and an artificial intelligence (AI)‐based system was applied to automatically classify BM nu…
View article: Neoadjuvant immunochemotherapy with adebrelimab combined with the TP regimen for locally advanced OSCC: early results of a single-arm phase II clinical trial
Neoadjuvant immunochemotherapy with adebrelimab combined with the TP regimen for locally advanced OSCC: early results of a single-arm phase II clinical trial Open
Background: This study aimed to investigate the efficacy of a PD-L1 inhibitor combined with chemotherapy in the treatment of locally advanced oral squamous cell carcinoma (OSCC). Materials and Methods: This study was designed as a single-a…
View article: Exploring the Causal Relationship Between Plasma Proteins and Obstructive Sleep Apnea: A Study Using Genome-Wide Mendelian Randomization, Single-Cell RNA Sequencing Analysis, and Network Pharmacology
Exploring the Causal Relationship Between Plasma Proteins and Obstructive Sleep Apnea: A Study Using Genome-Wide Mendelian Randomization, Single-Cell RNA Sequencing Analysis, and Network Pharmacology Open
Observational studies suggest that plasma proteins play a crucial role in the development and progression of obstructive sleep apnea (OSA); however, the causal relationship between plasma proteins and OSA remains controversial. This study …
View article: Microbiome analysis reveals gut bacterial alterations in adult Tibetan pigs with diarrhea
Microbiome analysis reveals gut bacterial alterations in adult Tibetan pigs with diarrhea Open
Diarrhea is a significant ailment that causes heavy economic losses in the pig industry. The Tibetan pig is a native Chinese breed that is unique to high-altitude regions and displays strong disease resistance. However, scientific research…
View article: Betaine promotes chicken growth through modulating gut microbiota and FXR-mediated activation of IGF genes
Betaine promotes chicken growth through modulating gut microbiota and FXR-mediated activation of IGF genes Open
Betaine is a growth-promoting additive used in both the animal production and microbial fermentation industries. The primary mechanisms by which betaine promotes animal growth are well known through its direct action on the host cells. How…
View article: Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade
Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade Open
Initial investigations established osteocalcin (OCN) as a pivotal factor in bone formation. Fully carboxylated osteocalcin (cOCN) exhibits a high affinity for hydroxyapatite within the bone matrix, yet under specific physiological conditio…
View article: Platelet Transfusion for Patients with Cancer: An Update
Platelet Transfusion for Patients with Cancer: An Update Open
Background: Platelet transfusion is essential for preventing and treating hemorrhage in oncology patients and can markedly improve quality of life and survival. However, access to platelet concentrates is often limited by global shortages …
View article: Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury
Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury Open
Introduction Traumatic brain injury (TBI) is a leading cause of death and disability globally. Several studies have shown that 5-lipoxygenase (5-LOX) inhibition reduces leukotriene (LT) release and the inflammatory response, attenuating th…
View article: Cinnamaldehyde prevents coronary artery spasm by down-regulating the function and expression of voltage-gated Ca2+ channels and Ca2+ -activated Cl- channels in the arterial smooth muscle cells
Cinnamaldehyde prevents coronary artery spasm by down-regulating the function and expression of voltage-gated Ca2+ channels and Ca2+ -activated Cl- channels in the arterial smooth muscle cells Open
CinA induces vasorelaxation in various arteries and its vasorelaxation efficiencies vary with arteries and vasoconstrictors. Down-regulation of VGCC and CaCC contributes to the coronarospasmolysis of CinA, while repression on Kv channels a…
View article: Application of induced pluripotent stem cells in the conservation of endangered animals
Application of induced pluripotent stem cells in the conservation of endangered animals Open
The accelerating biodiversity crisis urgently demands innovative approaches that transcend traditional conservation strategies, which are often constrained by genetic bottlenecks and disease risks. Induced pluripotent stem cells (iPSCs) te…
View article: Dynamic deployment of H2A.Z positive nucleosome mediated transcriptomic plasticity within vascular smooth muscle cell
Dynamic deployment of H2A.Z positive nucleosome mediated transcriptomic plasticity within vascular smooth muscle cell Open
Vascular SMCs dynamically deployed H2A.Z-positive nucleosomes extending continuously downstream transcription start sites on different genes to support their transcriptional adjustability, which served as an important mechanism mediating c…
View article: FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice
FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice Open
Postmenopausal osteoporosis (PMOP) is a condition in women caused by estrogen deficiency, characterized by reduced bone mass and increased fracture risk. Fatty acid-binding protein 4 (FABP4), a lipid-binding protein involved in metabolism …
View article: Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes Open
The protective effect of isorhamnetin on myocardial injury induced by isoproterenol (ISO) was investigated to identify the key targets and pathways involved, offering potential therapeutic insights for cardiovascular diseases. A myocardial…