Zixin Deng
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View article: Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria
Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria Open
Steroids are among the most valuable and widely used pharmaceuticals. The cholesterol side-chain cleavage enzyme (P450scc) is critical for steroid metabolism and hormone biosynthesis. While mammalian eukaryotic P450scc enzymes are well-cha…
View article: Microglial estrogen receptor 1 signal designates sexual dimorphism of AQP4 antibody-induced neuroinflammation and demyelination
Microglial estrogen receptor 1 signal designates sexual dimorphism of AQP4 antibody-induced neuroinflammation and demyelination Open
Neuromyelitis optica spectrum disorder, often linked to autoimmune antibodies against aquaporin-4 (AQP4), is a demyelinating disease exhibiting a profound sex bias in female patients. However, the pathophysiological mechanism underlying th…
View article: A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster
A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster Open
Astilbe chinensis, a perennial ornamental plant in the Saxifragaceae family, is recognized for its medicinal properties due to its diverse secondary metabolites. Here, we generate a chromosome-level genome assembly of A. chinensis. Our ana…
View article: Prediction of Refracture After Surgery for Osteoporotic Vertebral Compression Fractures Using the Vertebral B one Quality Index on T1- and T2-Weighted MRI
Prediction of Refracture After Surgery for Osteoporotic Vertebral Compression Fractures Using the Vertebral B one Quality Index on T1- and T2-Weighted MRI Open
Objective : To evaluate the value of the vertebral bone quality (VBQ) index on MRI in predicting refracture after percutaneous vertebral augmentation (PVA) for osteoporotic vertebral compression fractures (OVCF), and to compare its perform…
View article: An Analysis of Public Sector Employment, Race, Education, and Womens Wages in the 1980s
An Analysis of Public Sector Employment, Race, Education, and Womens Wages in the 1980s Open
This essay examines the role that U.S. public-sector employment played in shaping access to jobs and wage levels among Black and White non-Hispanic women between 1980 and 1990. Comparing Current Population Survey Annual Social and Economic…
View article: Duramycin: Exploring the therapeutic frontier of a unique lantibiotic
Duramycin: Exploring the therapeutic frontier of a unique lantibiotic Open
This review evaluates duramycin, a lantibiotic antimicrobial peptide, focusing on its biochemical properties, biosynthetic mechanisms, structural characteristics, and therapeutic applications. We examine the critical role of lanthionine an…
View article: Fusobacterium lineage profiling facilitates the clarification of the associations between non-nucleatum Fusobacterium and colorectal cancer
Fusobacterium lineage profiling facilitates the clarification of the associations between non-nucleatum Fusobacterium and colorectal cancer Open
Non-nucleatum Fusobacterium may play a nonnegligible role in colorectal cancer (CRC) and certain Fusobacterium lineages (namely, L1 and L5) have shown specific associations with CRC. We aim to clarify the complex connections between Fusoba…
View article: A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway
A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway Open
mRNA vaccines, featured by incorporated pseudouridine (Ψ), represent a milestone in combating diseases, thus highlighting Ψ importance in drug development. However, economic and environmental challenges have persisted in sustainable Ψ prod…
View article: A new family of StnC-like pseudo-FMN-preferred reductase components in two-component flavoprotein monooxygenases
A new family of StnC-like pseudo-FMN-preferred reductase components in two-component flavoprotein monooxygenases Open
The reductase components of two-component flavoprotein monooxygenases (FPMOs) can reduce flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD) for their monooxygenase partners. Typically, the type of flavin cofactor bound by a f…
View article: Clinical application study of a novel fully automatic erythrocyte osmotic fragility analysis system
Clinical application study of a novel fully automatic erythrocyte osmotic fragility analysis system Open
View article: Association of Erythrocyte Distribution Width with the Albumin-to- Ratio (RAR) and Osteoporosis: Mediation by Obesity Indicators (BRI/ABSI)
Association of Erythrocyte Distribution Width with the Albumin-to- Ratio (RAR) and Osteoporosis: Mediation by Obesity Indicators (BRI/ABSI) Open
Background: The Albumin-to-Ratio (RAR) value represents an innovative composite indicator defined as the ratio of red blood cell distribution width (RDW) to serum albumin（SA）. Recent research has highlighted its potential as a biomarker in…
View article: Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy) <sub>3</sub> <sup>2+</sup> Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER
Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy) <sub>3</sub> <sup>2+</sup> Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER Open
Reactive oxygen species (ROS) have gained increasing attention in electrochemiluminescence (ECL) as endogenous co‐reactants, yet their application in the most widely used tris(bipyridine)‐ruthenium(II) system remains limited due to the sca…
View article: Evaluating the clinical evidence of TCM in Alzheimer’s disease: an evidence map perspective
Evaluating the clinical evidence of TCM in Alzheimer’s disease: an evidence map perspective Open
Objective This systematic review aimed to synthesize current clinical evidence from randomized controlled trial (RCT) and meta-analyses on the efficacy and safety of TCM in the treatment of Alzheimer’s Disease (AD). Methods Systematic sear…
View article: Development of a versatile chassis for the efficient production of diverse type II polyketides
Development of a versatile chassis for the efficient production of diverse type II polyketides Open
View article: The antibacterial effect of tellurite is achieved through intracellular acidification and magnesium disruption
The antibacterial effect of tellurite is achieved through intracellular acidification and magnesium disruption Open
Antibiotic resistance has caused a severe reduction in bacteriostatic action and clinical therapy, demanding effective agents or strategies. Tellurite is an ancient yet powerful antimicrobial agent with an ambiguous mechanism. In this stud…
View article: Precision-Engineered Co-N4-x-Cx Single Atoms Enhance Potential-Resolved Ru(bpy)32+ Electrochemiluminescence via Reactive Oxygen Species
Precision-Engineered Co-N4-x-Cx Single Atoms Enhance Potential-Resolved Ru(bpy)32+ Electrochemiluminescence via Reactive Oxygen Species Open
Electrochemiluminescence (ECL) immunoassays based on tris(bipyridine)ruthenium [Ru(bpy)3 2+] is the luminophore representing the most advanced and widely adopted approach in the field of in vitro diagnostics (IVD). Ho…
View article: Blood‑brain barrier dysfunction in epilepsy: Mechanisms, therapeutic strategies and future orientation (Review)
Blood‑brain barrier dysfunction in epilepsy: Mechanisms, therapeutic strategies and future orientation (Review) Open
The blood‑brain barrier (BBB) is a crucial structure for maintaining homeostasis within the central nervous system, and its integrity plays a pivotal role in the onset and progression of epilepsy. Epileptic seizures can disrupt the molecul…
View article: Development and validation of a clinical prediction model for osteoporosis diagnosis by lumbosacral X-ray and radiomics
Development and validation of a clinical prediction model for osteoporosis diagnosis by lumbosacral X-ray and radiomics Open
Purpose To develop a clinical prediction model for the diagnosis of osteoporosis using lumbosacral X-ray images through radiomics analysis. Methods A total of 272 patients who underwent dual-energy X-ray absorptiometry (DXA) and lumbosacra…
View article: Aglycone Polyether Ionophores Affecting Actin Filaments as Broad-Spectrum Antiviral Agents
Aglycone Polyether Ionophores Affecting Actin Filaments as Broad-Spectrum Antiviral Agents Open
RNA viruses have high mutation rates and constitute an increasing global risk. As the viral target approach to develop antiviral drugs is inadequate for responding to an increasing diversity of viruses, an urgent need exists for the develo…
View article: The Final Steps in Pseudoiodinine Biosynthesis Feature Ring-Contractive N–N Bond Formation
The Final Steps in Pseudoiodinine Biosynthesis Feature Ring-Contractive N–N Bond Formation Open
Pseudoiodinine (PSD) is a N-N bond-containing natural product with profound antimicrobial and antifungal activities. In this work, we have completed the PSD biosynthetic pathway by explicating the final three steps, which involve an enigma…
View article: Production of Aniline Derivatives from <i>Cladosporium cladosporioides</i> TFU‐13 and <i>Volutella</i> sp. TFU‐28 in the Presence of SAHA
Production of Aniline Derivatives from <i>Cladosporium cladosporioides</i> TFU‐13 and <i>Volutella</i> sp. TFU‐28 in the Presence of SAHA Open
Biotransformation of suberoylanilide hydroxamic acid (SAHA) by soil‐derived Cladosporium cladosporioides TFU‐13 and Volutella sp. TFU‐28 yielded a panel of aniline derivatives, including two new metabolites ( 1 and 4 ) and six previously r…
View article: Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis
Estrogen receptor 1 signaling in hepatic stellate cells designates resistance to liver fibrosis Open
View article: dTSR enables efficient improvement of heterologous production of spinosad in Saccharopolyspora erythraea
dTSR enables efficient improvement of heterologous production of spinosad in Saccharopolyspora erythraea Open
View article: Cytochrome P450-catalyzed allylic oxidation of pentalenene to 1-deoxypentalenic acid in pentalenolactone biosynthesis
Cytochrome P450-catalyzed allylic oxidation of pentalenene to 1-deoxypentalenic acid in pentalenolactone biosynthesis Open
Pentalenolactone is a sesquiterpene antibiotic from Streptomyces. Its biosynthetic pathway has been elucidated, except for the oxidation of pentalen-13-al to 1-deoxypentalenic acid. In this study, we show that cytochrome P450 pentalenene o…
View article: The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates <i>n</i>‐alkane degradation in <i>Pseudomonas aeruginosa</i> SJTD‐1
The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates <i>n</i>‐alkane degradation in <i>Pseudomonas aeruginosa</i> SJTD‐1 Open
Transmembrane alkane monooxygenase (AlkB)‐type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium‐to‐long‐chain n ‐alkanes in hydrocarbon‐utilizing microorganisms. In this study, we identifie…
View article: Interdomain Coordination Determines Polyketide Extender Unit Specificity in UK‐2A Biosynthesis
Interdomain Coordination Determines Polyketide Extender Unit Specificity in UK‐2A Biosynthesis Open
Controlling the incorporation of extender units is a key strategy for manipulating polyketide scaffolds. Current understanding suggests that extender unit incorporation by modular polyketide synthase (PKS) is primarily regulated by acyltra…
View article: Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib
Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib Open
Multidrug resistance proteins (MRPs) are one of the major mechanisms for developing cancer drug resistance. Human MRP4 (hMRP4) plays an important role in various chemotherapy-resistant cancers. Here, we show hMRP4 mediates the resistance o…
View article: Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia
Mediation by elevated prolactin in the relationship between childhood trauma and first-episode drug-naïve schizophrenia Open
View article: SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials Open
Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental and clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic and programmable materials…
View article: In-Situ Purification of Non-Ribosomal Peptide Synthetases Assembly Line for Structural and Biochemical Studies
In-Situ Purification of Non-Ribosomal Peptide Synthetases Assembly Line for Structural and Biochemical Studies Open
Nonribosomal peptide synthetases (NRPS) are essential for the biosynthesis of therapeutically valuable molecules, including antibiotics, immunosuppressants, and anticancer agents. The assembly-line mechanism of NRPS offers significant pote…