Xinchang Chen
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View article: Diagnostic performance of the Sanity 2.0 assay to detect resistance to rifampicin, isoniazid, and fluoroquinolones in tuberculosis
Diagnostic performance of the Sanity 2.0 assay to detect resistance to rifampicin, isoniazid, and fluoroquinolones in tuberculosis Open
Effective tuberculosis (TB) management relies on prompt diagnosis of Mycobacterium tuberculosis complex (MTBC) and associated drug resistance. The Sanity 2.0 assay is a high-resolution melting assay designed for direct respiratory sample t…
View article: A Novel Compound Heterozygous Mutation in the IL12RB1 Gene Causes Susceptibility To Mycobacterium Tilburgii Infection
A Novel Compound Heterozygous Mutation in the IL12RB1 Gene Causes Susceptibility To Mycobacterium Tilburgii Infection Open
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare clinical syndrome that is characterized by selective vulnerability to intracellular pathogens. Deficiency in IL12RB1 is the most common type of MSMD but the heterogeneity o…
View article: Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus
Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus Open
Mycobacterium abscessus ( MAB ) is a clinically significant multidrug-resistant (MDR) pathogen, particularly implicated in pulmonary infections among cystic fibrosis (CF) patients. Tedizolid (TZD), an oxazolidinone-class antibacterial drug…
View article: Identification of drug resistance-related virulence gene mutations in 667 clinical Mycobacterium tuberculosis isolates
Identification of drug resistance-related virulence gene mutations in 667 clinical Mycobacterium tuberculosis isolates Open
Introduction: Drug-resistant tuberculosis is a severe global public health threat. Virulence factors and antibiotic resistance are generally considered to play a significant role in bacterial pathogenesis. However, the interaction between …
View article: Mutations in the promoter region of methionine transporter gene <i>metM</i> (Rv3253c) confer <i>para</i> -aminosalicylic acid (PAS) resistance in <i>Mycobacterium tuberculosis</i>
Mutations in the promoter region of methionine transporter gene <i>metM</i> (Rv3253c) confer <i>para</i> -aminosalicylic acid (PAS) resistance in <i>Mycobacterium tuberculosis</i> Open
Although para -aminosalicylic acid (PAS) has been used to treat TB for more than 70 years, the understanding of PAS resistance mechanisms is still vague, living gaps in our ability to predict resistance and apply PAS effectively in clinica…
View article: The Influence of Bedroom CO2 Concentration on Sleep Quality
The Influence of Bedroom CO2 Concentration on Sleep Quality Open
A person spends about a third of their life sleeping, and high sleep quality is very important for health. Environmental factors are one of the most important factors affecting sleep quality, and indoor carbon dioxide (CO2) concentration w…
View article: Rapid Detection of Extensive Drug Resistance by Xpert MTB/XDR Optimizes Therapeutic Decision-Making in Rifampin-Resistant Tuberculosis Patients
Rapid Detection of Extensive Drug Resistance by Xpert MTB/XDR Optimizes Therapeutic Decision-Making in Rifampin-Resistant Tuberculosis Patients Open
The Xpert MTB/XDR assay met the critical need for etiologic diagnosis of tuberculosis and rifampin resistance in previous studies. However, its benefits in tailoring the treatment regimen and improving the outcome for patients with rifampi…
View article: Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients
Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients Open
This study evaluated the accuracy of the MeltPro MTB/PZA assay at detecting the presence of PZA resistance through registered clinical trials. Compared to DNA sequencing, the assay had high sensitivity and negative predictive value, sugges…
View article: In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid
In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid Open
Our study demonstrates that TZD had greater in vitro potency than LZD, and synergy studies suggested that TZD may be an important component of multi-drug treatment regimen.
View article: Explore the Benefits of Natural Air: New Insights from Field and Chamber Tests on Cognitive Performance
Explore the Benefits of Natural Air: New Insights from Field and Chamber Tests on Cognitive Performance Open
Exposure to natural environments has a range of health benefits, including enhancing psychological restoration and cognitive development. While there are various explanations on the causes for the benefits of the natural exposure, such as …
View article: Additional file 1 of In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates
Additional file 1 of In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates Open
Additional file 1: Supplementary Table 1. MIC values of the clinical MAC isolates.
View article: In Vitro Assessment of 17 Antimicrobial Agents Against Clinical Mycobacterium Avium Complex Isolates
In Vitro Assessment of 17 Antimicrobial Agents Against Clinical Mycobacterium Avium Complex Isolates Open
Background: Recently, Mycobacterium avium complex (MAC) infections have been increasing, especially in immunocompromised and older adults. The rapid increase has triggered a global health concern due to limited therapeutic strategies and a…
View article: Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing
Analysis of Serial Multidrug-Resistant Tuberculosis Strains Causing Treatment Failure and Within-Host Evolution by Whole-Genome Sequencing Open
Few studies have focused on the reasons for the low cure rate of multidrug-resistant tuberculosis in China and within-host evolution during treatment, which is of great significance for improving clinical treatment regimens. Acquired resis…
View article: Prediction of treatment outcomes for multidrug-resistant tuberculosis by whole-genome sequencing
Prediction of treatment outcomes for multidrug-resistant tuberculosis by whole-genome sequencing Open
Whole-genome sequencing (WGS) has been proposed to be a powerful tool to predict drug resistance for antitubercular drugs. However, the feasibility of WGS in predicting final treatment outcomes for multidrug-resistant tuberculosis (MDR-TB)…
View article: Clinical Evaluation of Diagnosis Efficacy of Active Mycobacterium tuberculosis Complex Infection via Metagenomic Next-Generation Sequencing of Direct Clinical Samples
Clinical Evaluation of Diagnosis Efficacy of Active Mycobacterium tuberculosis Complex Infection via Metagenomic Next-Generation Sequencing of Direct Clinical Samples Open
Background: Tuberculosis (TB) is now the leading cause of death from infectious disease. Rapid screening and diagnostic methods for TB are urgently required. Rapid development of metagenomics next-generation sequencing (mNGS) in recent yea…
View article: Corrigendum: Evaluation of Whole-Genome Sequence Method to Diagnose Resistance of 13 Anti-tuberculosis Drugs and Characterize Resistance Genes in Clinical Multi-Drug Resistance Mycobacterium tuberculosis Isolates From China
Corrigendum: Evaluation of Whole-Genome Sequence Method to Diagnose Resistance of 13 Anti-tuberculosis Drugs and Characterize Resistance Genes in Clinical Multi-Drug Resistance Mycobacterium tuberculosis Isolates From China Open
Dear editor,We are sorry to write to you that we want to correct a mistake in our recently published article "Evaluation of whole-genome sequence method to diagnose resistance of 13 anti-tuberculosis drugs and characterize resistance genes…
View article: Evaluation of Whole-Genome Sequence Method to Diagnose Resistance of 13 Anti-tuberculosis Drugs and Characterize Resistance Genes in Clinical Multi-Drug Resistance Mycobacterium tuberculosis Isolates From China
Evaluation of Whole-Genome Sequence Method to Diagnose Resistance of 13 Anti-tuberculosis Drugs and Characterize Resistance Genes in Clinical Multi-Drug Resistance Mycobacterium tuberculosis Isolates From China Open
Background: Whole-genome sequencing (WGS) is a viable and financially feasible tool for timely and comprehensive diagnosis of drug resistance in developed countries. With the increase in the incidence of multidrug-resistant tuberculosis (M…
View article: Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: a single-center retrospective observational study in China
Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection: a single-center retrospective observational study in China Open
Background Infections still represent the main factors influencing morbidity and mortality following liver transplantation. This study is to evaluate the incidence and risk factors for infection and survival after liver transplantation. Me…
View article: <p>Cycloserine for treatment of multidrug-resistant tuberculosis: a retrospective cohort study in China</p>
Cycloserine for treatment of multidrug-resistant tuberculosis: a retrospective cohort study in China Open
Cycloserine is an attractive agent for the treatment of MDR-TB, and its safety profile warrants its use in most MDR-TB cases. Cycloserine significantly improved the chance of a favorable outcome for patients with simple MDR-TB but not pre-…
View article: A two-step algorithm for rapid diagnosis of active pulmonary tuberculosis in entry applicants using the T-SPOT.TB and Xpert MTB/RIF assays in Shanghai, China
A two-step algorithm for rapid diagnosis of active pulmonary tuberculosis in entry applicants using the T-SPOT.TB and Xpert MTB/RIF assays in Shanghai, China Open
Emerging Microbes & Infections (2017) 6, e67; doi:10.1038/emi.2017.52; published online 26 July 2017