Xinchen Teng
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View article: P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice
P2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice Open
Purpose: Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. …
View article: The Purinergic P2X7 Receptor as a Target for Adjunctive Treatment for Drug-Refractory Epilepsy
The Purinergic P2X7 Receptor as a Target for Adjunctive Treatment for Drug-Refractory Epilepsy Open
Epilepsy is one of the most common neurological diseases worldwide. Anti-seizure medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment. Currently used ASMs are, however, ineffective to suppress seizures in about…
View article: Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice Open
Our results suggest a dual and opposing action of P2X7R in epilepsy and suggest P2X7R overexpression in GABAergic interneurons as a novel therapeutic strategy for acquired and, possibly, genetic forms of epilepsy.
View article: Gene-dependent yeast cell death pathway requires AP-3 vesicle trafficking leading to vacuole membrane permeabilization
Gene-dependent yeast cell death pathway requires AP-3 vesicle trafficking leading to vacuole membrane permeabilization Open
Unicellular eukaryotes are suggested to undergo self-inflicted destruction. However, molecular details are sparse by comparison to the mechanisms of cell death known for human cells and animal models. Here we report a molecular pathway in …
View article: Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia
Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia Open
Large-conductance calcium-activated potassium (BK) channels are ubiquitously expressed in most cell types where they regulate many cellular, organ, and organismal functions. Although BK currents have been recorded specifically in activated…
View article: <i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
<i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders Open
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not appr…
View article: <i>KCTD7</i> deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect
<i>KCTD7</i> deficiency defines a distinct neurodegenerative disorder with a conserved autophagy‐lysosome defect Open
Objective Several small case series identified KCTD7 mutations in patients with a rare autosomal recessive disorder designated progressive myoclonic epilepsy (EPM3) and neuronal ceroid lipofuscinosis (CLN14). Despite the name KCTD (potassi…
View article: Whi2 signals low leucine availability to halt yeast growth and cell death
Whi2 signals low leucine availability to halt yeast growth and cell death Open
Cells are exquisitely tuned to environmental ques. Amino acid availability is rapidly sensed, allowing cells to adjust molecular processes and implement short or long-term metabolic shifts accordingly. How levels of most individual amino a…
View article: Whi2 is a conserved negative regulator of TORC1 in response to low amino acids
Whi2 is a conserved negative regulator of TORC1 in response to low amino acids Open
Yeast WHI2 was originally identified in a genetic screen for regulators of cell cycle arrest and later suggested to function in general stress responses. However, the function of Whi2 is unknown. Whi2 has predicted structure and sequence s…