Xindan Xing
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View article: Dysregulated serum lipid profiles in neovascular age-related macular degeneration revealed by UPLC‒MS/MS lipidomics
Dysregulated serum lipid profiles in neovascular age-related macular degeneration revealed by UPLC‒MS/MS lipidomics Open
View article: Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings
Mucosal adenovirus vaccine Ad5-XBB.1.5 boosting elicits nasal IgA and transiently prevents JN.1 wave infection for less than 6 months in real-world settings Open
View article: High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes
High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes Open
View article: <i>In vivo</i> determination of protective antibody thresholds for SARS-CoV-2 variants using mouse models
<i>In vivo</i> determination of protective antibody thresholds for SARS-CoV-2 variants using mouse models Open
Neutralizing antibody titres have been shown to correlate with immune protection against COVID-19 and can be used to estimate vaccine effectiveness. Numerous studies have explored the relationship between neutralizing antibodies and protec…
View article: Progress in The Application of CRISPR-Cas9 Combined With Microbial Engineering
Progress in The Application of CRISPR-Cas9 Combined With Microbial Engineering Open
CRISPR - Cas9 as the third generation of gene editing techniques, widely exists in prokaryotes, and has been widely applied to clinical and pharmaceutical fields. This article reviews the discovery, immune defense process and mechanism of …
View article: High Levels of Serum Uric Acid are Associated with Microvascular Complications in Patients with Long-term Diabetes
High Levels of Serum Uric Acid are Associated with Microvascular Complications in Patients with Long-term Diabetes Open
Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted invol…
View article: Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway
Small-molecule agonist AdipoRon alleviates diabetic retinopathy through the AdipoR1/AMPK/EGR4 pathway Open
Background Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) is the main complication of DM in the eyes and causes irreversible vision loss. In the p…
View article: ABHD1 Facilitates Intermediate Filament–Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy
ABHD1 Facilitates Intermediate Filament–Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy Open
Diabetic retinopathy (DR) is one of the most common complications of diabetes and induces severe visual impairment worldwide. Endothelial cell dysfunction plays an important role in the pathogenesis of DR. Here, we keep a watchful eye on α…
View article: <scp>MEK1</scp>‐dependent <scp>MondoA</scp> phosphorylation regulates glucose uptake in response to ketone bodies in colorectal cancer cells
<span>MEK1</span>‐dependent <span>MondoA</span> phosphorylation regulates glucose uptake in response to ketone bodies in colorectal cancer cells Open
The Mondo family transcription factor MondoA plays a pivotal role in sensing metabolites, such as glucose, glutamine, and lactic acid, to regulate glucose metabolism and cell proliferation. Ketone bodies are important signals for reducing …
View article: Protective effect of pentraxin 3 on pathological retinal angiogenesis in an in vitro model of diabetic retinopathy
Protective effect of pentraxin 3 on pathological retinal angiogenesis in an in vitro model of diabetic retinopathy Open
The upregulated expression of PTX3 may play a protective role on pathological angiogenesis in DR. PTX3 may serve as a new target for the treatment of DR.
View article: RUNX1 can mediate the glucose and O-GlcNAc-driven proliferation and migration of human retinal microvascular endothelial cells
RUNX1 can mediate the glucose and O-GlcNAc-driven proliferation and migration of human retinal microvascular endothelial cells Open
Introduction This study aims to determine whether high glucose condition and dynamic O-linked N-acetylglucosamine (O-GlcNAc) modification can promote the proliferation and migration of human retinal microvascular endothelial cells (HRMECs)…
View article: Pathogenesis Study Based on High Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice
Pathogenesis Study Based on High Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice Open
Diabetic retinopathy (DR) is the leading cause of acquired blindness in middle-aged people. The complex pathology of DR is difficult to dissect, given the convoluted cytoarchitecture of the retina. Here, we performed single-cell RNA sequen…
View article: Pathogenesis Study Based on High Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice
Pathogenesis Study Based on High Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice Open
Diabetic retinopathy (DR) is the leading cause of acquired blindness in middle-aged people. The complex pathology of DR is difficult to dissect, given the convoluted cytoarchitecture of the retina. Here, we performed single-cell RNA sequen…
View article: Pathogenesis Study Based on High-Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice
Pathogenesis Study Based on High-Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic Mice Open
Diabetic retinopathy (DR) is the leading cause of acquired blindness in middle-aged people. The complex pathology of DR is difficult to dissect, given the convoluted cytoarchitecture of the retina. Here, we performed single-cell RNA sequen…
View article: The Anti-Inflammatory Effect of KS23, A Novel Peptide Derived From Globular Adiponectin, on Endotoxin-Induced Uveitis in Rats
The Anti-Inflammatory Effect of KS23, A Novel Peptide Derived From Globular Adiponectin, on Endotoxin-Induced Uveitis in Rats Open
Purpose: Adiponectin has been shown to exert potent anti-inflammatory activities in a range of systemic inflammatory diseases. This study aimed to investigate the potential therapeutic effects of KS23, a globular adiponectin-derived peptid…
View article: Identification of novel differentially expressed genes in retinas of STZ‐induced long‐term diabetic rats through RNA sequencing
Identification of novel differentially expressed genes in retinas of STZ‐induced long‐term diabetic rats through RNA sequencing Open
Background The aim of this research was to investigate the retinal transcriptome changes in long‐term streptozotocin (STZ)‐induced rats' retinas using RNA sequencing (RNA‐seq), to explore the molecular mechanisms of diabetic retinopathy (D…
View article: Endomucin restores depleted endothelial glycocalyx in the retinas of streptozotocin‐induced diabetic rats
Endomucin restores depleted endothelial glycocalyx in the retinas of streptozotocin‐induced diabetic rats Open
Endothelial glycocalyx plays a significant role in the development and progression of diabetic complications. Endomucin (EMCN) is an anti‐inflammatory membrane glycoprotein that is mainly expressed in venous and capillary endothelial cells…