Xijun Wang
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View article: Ginseng-Derived Carbon Quantum Dots Enhance Systemic Exposure of Bioactive Ginsenosides and Amplify Energy Metabolism in Mice
Ginseng-Derived Carbon Quantum Dots Enhance Systemic Exposure of Bioactive Ginsenosides and Amplify Energy Metabolism in Mice Open
Objective: To overcome the extremely low oral bioavailability of ginsenosides in traditional ginseng preparations, this study aimed to evaluate the efficacy of a novel ginseng-derived carbon quantum dots (G-CQDs) delivery system and to elu…
View article: Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies
Dysregulated bile acid metabolism as a novel player in gout progression: emerging therapeutic strategies Open
Gout, a prevalent metabolic disorder driven by hyperuricemia, results in pathological deposition of monosodium urate (MSU) crystals in joints and soft tissues, stimulating intense inflammatory responses with systemic health consequences. E…
View article: Construction of a Risk Score Model for Predicting Airway Management in Maxillofacial and Neck Region Space Infections Using Inflammatory Markers
Construction of a Risk Score Model for Predicting Airway Management in Maxillofacial and Neck Region Space Infections Using Inflammatory Markers Open
The proposed risk scoring system reliably predicts the need for airway management in OMSI patients, which enables clinicians to identify high-risk patients early and implement preventive strategies to improve outcomes.
View article: Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic targeting
Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic targeting Open
Gouty arthritis (GA), a condition characterized by monosodium urate (MSU) crystal deposition and NLRP3 inflammasome-driven inflammation, is a result of a complex interplay between hyperuricemia and immune dysregulation, which leads to syst…
View article: Nuclear Magnetic Resonance Based Metabolomics—A Rising Star in Traditional Chinese Medicine Research
Nuclear Magnetic Resonance Based Metabolomics—A Rising Star in Traditional Chinese Medicine Research Open
Metabolomics, a promising field in the realm of omics, focuses on the investigation of alterations and patterns in the composition and abundance of metabolites generated by organisms under perturbation, directly linking measurable chemical…
View article: Development and Immunogenic Evaluation of a Recombinant Vesicular Stomatitis Virus Expressing Nipah Virus F and G Glycoproteins
Development and Immunogenic Evaluation of a Recombinant Vesicular Stomatitis Virus Expressing Nipah Virus F and G Glycoproteins Open
Nipah virus (NiV) is a highly pathogenic bat-borne zoonotic pathogen that poses a significant threat to human and animal health, with fatality rates exceeding 70% in some outbreaks. Despite its significant public health impact, there are c…
View article: Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization
Lumpy skin disease virus 001/156 protein is a virulence factor that suppresses interferon production through impairing IRF3 dimerization Open
Lumpy skin disease virus (LSDV), a member of the genus Capripoxvirus within the family Poxviridae , causes significant disease in cattle and is classified as a notifiable disease by the World Organization for Animal Health (WOAH). The viru…
View article: Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization
Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization Open
Rabies virus (RABV), belonging to the rhabdovirus, is a typical large virus that enters cells via clathrin-mediated endocytosis (CME). RABV-containing pits are only partially clathrin-coated and require local actin polymerization for effic…
View article: Defining Multi-Trait Breeding Objectives and Selection Indexes to Develop More Efficient Breeding Programs for Superfine Wool Sheep
Defining Multi-Trait Breeding Objectives and Selection Indexes to Develop More Efficient Breeding Programs for Superfine Wool Sheep Open
This study aimed to develop an optimized breeding program for the Alpine Merino sheep superfine strain by defining breeding objectives and establishing a multi-trait selection index. Using phenotypic and genetic (co)variance components of …
View article: Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs
Safety and Immunogenicity of a Canine Distemper DNA Vaccine Formulated with Lipid Nanoparticles in Dogs, Foxes, and Raccoon Dogs Open
Background: canine distemper (CD) is a highly contagious and fatal disease caused by canine distemper virus (CDV), posing a significant threat to carnivores. New CDV strain circulation and multi-species infection may lead to the potential …
View article: Research progress on the hepatoprotective effect, pharmacokinetic properties, and hepatotoxicity of geniposide
Research progress on the hepatoprotective effect, pharmacokinetic properties, and hepatotoxicity of geniposide Open
Liver disease (LD) is a global health problem caused by multiple factors. At present, there are still obvious problems with limited efficacy and strong side effects of drugs used in the clinical treatment of LD. Therefore, it is of great s…
View article: Cancer chemoprevention: signaling pathways and strategic approaches
Cancer chemoprevention: signaling pathways and strategic approaches Open
Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from cancer invasion or recurrence, only over ten drugs have been approved by the U.S. Food and Drug Administration. Therefore, screeni…
View article: Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
Multimodal lung cancer theranostics via manganese phosphate/quercetin particle Open
The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due to the lack of integration between the two processes, which limit real-time adjustments in treatment plans based on th…
View article: Fingerprint Profile Analysis of Eupolyphaga steleophaga Polypeptide Based on UHPLC-MS and Its Application
Fingerprint Profile Analysis of Eupolyphaga steleophaga Polypeptide Based on UHPLC-MS and Its Application Open
Background and Objectives: As a medicinal and food homologous substance, Eupolyphaga steleophaga is renowned for its potential health benefits, including anti-tumor effects, immune system support, and anti-inflammatory properties. Eupolyph…
View article: MSU-Mamba: Multi-Scale Defocus Blur Detection Using Cross-Scale Fusion and State Space Models
MSU-Mamba: Multi-Scale Defocus Blur Detection Using Cross-Scale Fusion and State Space Models Open
Defocus blur detection (DBD) plays a pivotal role in computer vision, serving as a fundamental step to enhance the performance of various downstream applications, such as image refocusing, depth estimation, and saliency detection. Despite …
View article: Personalized Generative Low-light Image Denoising and Enhancement
Personalized Generative Low-light Image Denoising and Enhancement Open
Modern cameras' performance in low-light conditions remains suboptimal due to fundamental limitations in photon shot noise and sensor read noise. Generative image restoration methods have shown promising results compared to traditional app…
View article: Rhein: An Updated Review Concerning Its Biological Activity, Pharmacokinetics, Structure Optimization, and Future Pharmaceutical Applications
Rhein: An Updated Review Concerning Its Biological Activity, Pharmacokinetics, Structure Optimization, and Future Pharmaceutical Applications Open
Rhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities. However, its clinical application is limited by low water solubility, poor oral abs…
View article: Generative Photography: Scene-Consistent Camera Control for Realistic Text-to-Image Synthesis
Generative Photography: Scene-Consistent Camera Control for Realistic Text-to-Image Synthesis Open
Image generation today can produce somewhat realistic images from text prompts. However, if one asks the generator to synthesize a specific camera setting such as creating different fields of view using a 24mm lens versus a 70mm lens, the …
View article: Monitoring C–C coupling in catalytic reactions via machine-learned infrared spectroscopy
Monitoring C–C coupling in catalytic reactions via machine-learned infrared spectroscopy Open
Tracking atomic structural evolution along chemical transformation pathways is essential for optimizing chemical transitions and enhancing control. However, molecule-level knowledge of structural rearrangements during chemical processes re…
View article: WorldSimBench: Towards Video Generation Models as World Simulators
WorldSimBench: Towards Video Generation Models as World Simulators Open
Recent advancements in predictive models have demonstrated exceptional capabilities in predicting the future state of objects and scenes. However, the lack of categorization based on inherent characteristics continues to hinder the progres…
View article: In vivo components analysis of Shenhua tablets active in IgA nephropathy
In vivo components analysis of Shenhua tablets active in IgA nephropathy Open
Introduction: Shenhua Tablet (SH), a traditional Chinese medicine (TCM) formulation with seven herbs, is widely used in the clinical treatment of Immunoglobulin A (IgA) nephropathy. Despite its effectiveness, the specific active components…
View article: Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission
Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission Open
Minks are highly susceptible to SARS-CoV-2, and have transmitted SARS-CoV-2 to humans. Oral immunization is one of the most promising strategies to prevent SARS-CoV-2 infection and transmission in minks. Here, we generated 3 recombinant ra…
View article: Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites
Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites Open
Diabetic cardiomyopathy (DCM) is a specific heart condition in diabetic patients, which is a major cause of heart failure and significantly affects quality of life. DCM is manifested as abnormal cardiac structure and function in the absenc…
View article: Evaluation of safety and immunogenicity of a genetically modified rabies virus for use as an oral vaccine in several non-target species1
Evaluation of safety and immunogenicity of a genetically modified rabies virus for use as an oral vaccine in several non-target species1 Open
Oral immunization is an alternative or supplementary approach that can significantly improve dog vaccination coverage, especially for free-roaming dogs. Safe and effective oral rabies vaccines for dogs are still being sought. In our previo…
View article: Research on Metal Corrosion Behaviour of Indirect Air-cooled Circulating Water System
Research on Metal Corrosion Behaviour of Indirect Air-cooled Circulating Water System Open
The indirect air cooling system of an air-cooled power plant consists of a surface condenser and an aluminum radiator. The radiator is usually made of 1050A pure aluminum, and the circulating water pipe connecting the radiator is made of Q…