Xiao Chen
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View article: Pyruvate Dehydrogenase Kinase 4 Underlies the Metabolic Disorder of Cardiomyocytes in Patients With Hypertrophic Cardiomyopathy From Hypertrophy to Heart Failure
Pyruvate Dehydrogenase Kinase 4 Underlies the Metabolic Disorder of Cardiomyocytes in Patients With Hypertrophic Cardiomyopathy From Hypertrophy to Heart Failure Open
Background Hypertrophic cardiomyopathy (HCM), characterized by ventricular hypertrophy and fibrosis, frequently progresses to heart failure. Although metabolic dysregulation is implicated in HCM pathophysiology, the role of PDK4 (pyruvate …
View article: Development of a 3D-3 co-culture microbead consisting of cancer-associated fibroblasts and human umbilical vein endothelial cells for the anti-tumor drug assessment of lung cancer
Development of a 3D-3 co-culture microbead consisting of cancer-associated fibroblasts and human umbilical vein endothelial cells for the anti-tumor drug assessment of lung cancer Open
These findings suggest that the patient-derived in vitro 3D-3 co-culture model, which highlighted the close association between tumor cell resistance and the TME, offers innovative ideas and methods for addressing treatment resistance in l…
View article: Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy
Photo-controlled co-delivery of verteporfin and acriflavine via platelets achieves potentiated glioblastoma-targeted photodynamic therapy Open
The potential of glioblastoma (GBM) photodynamic therapy (PDT) is limited by inadequate GBM drug delivery, and the development of resistance to PDT as a result of cellular damage response that critically involves the hypoxia-inducible fact…
View article: Quantitative Proteomic Analysis of Cardiac Xenograft Failure in a Pig‐to‐Non‐Human Primate Model Identifies NF‐κB as a Critical Immunomodulatory Target
Quantitative Proteomic Analysis of Cardiac Xenograft Failure in a Pig‐to‐Non‐Human Primate Model Identifies NF‐κB as a Critical Immunomodulatory Target Open
Introduction Shortage of donor organs is one of the greatest challenges of cardiac transplantation. Xenotransplantation is a potential way to solve the contradiction of imbalance and pigs are considered ideal donor sources. However, xenotr…
View article: Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma
Targeted sonodynamic therapy induces tumor cell quasi-immunogenic ferroptosis and macrophage immunostimulatory autophagy in glioblastoma Open
In this study, we demonstrated the mechanism of a glioblastoma (GBM)-targeted sonodynamic therapy (SDT) strategy employing platelets loaded with a sonosensitizer based on functionalized boron nitride nanoparticles carrying chlorin e6 (BNPD…
View article: SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis
SPHK1 promotes HNSCC immune evasion by regulating the MMP1-PD-L1 axis Open
Rationale: Immune checkpoint inhibitors (ICIs) have demonstrated significant efficacy against head and neck squamous cell carcinoma (HNSCC), but their overall response rate (ORR) remains limited. Previous studies have highlighted the cruci…
View article: Progress of nanoparticle drug delivery system for the treatment of glioma
Progress of nanoparticle drug delivery system for the treatment of glioma Open
Gliomas are typical malignant brain tumours affecting a wide population worldwide. Operation, as the common treatment for gliomas, is always accompanied by postoperative drug chemotherapy, but cannot cure patients. The main challenges are …
View article: PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer
PD-L1 blockade TAM-dependently potentiates mild photothermal therapy against triple-negative breast cancer Open
The present work was an endeavor to shed light on how mild photothermia possibly synergizes with immune checkpoint inhibition for tumor therapy. We established mild photothermal heating protocols to generate temperatures of 43 °C and 45 °C…
View article: Targeting the Cgas-Sting Pathway Inhibits the Progression and Enhances the Chemotherapy Efficacy of Peripheral T-Cell Lymphoma
Targeting the Cgas-Sting Pathway Inhibits the Progression and Enhances the Chemotherapy Efficacy of Peripheral T-Cell Lymphoma Open
Objective Peripheral T-cell lymphoma (PTCL) is a highly heterogeneous group of mature T-cell malignancies. Owing to its complex clinicopathological characteristics and diagnostic difficulties, the underlying molecular mechanism leading to …
View article: Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release
Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release Open
Sonodynamic therapy (SDT) has aroused great interest for its potential in the treatment of glioblastoma (GBM). SDT relies on tumor-selective accumulation of a sonosensitizer that is activated by ultrasound irradiation (UI) to generate cyto…
View article: Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle
Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle Open
In our previous study, target drug delivery and treatment of malignant tumors have been achieved by using platelets as carriers loading nano-chemotherapeutic agents (ND-DOX). However, drug release from ND-DOX-loaded platelets is dependent …
View article: Multiple Stimuli‐Response Polychromatic Carbon Dots for Advanced Information Encryption and Safety
Multiple Stimuli‐Response Polychromatic Carbon Dots for Advanced Information Encryption and Safety Open
Optical information encryption and safety have aroused great attention since they are closely correlated to data protection and information safety. The development of multiple stimuli‐response optical materials for constructing large‐capac…
View article: Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage
Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage Open
Lung cancer recruits tumor-associated macrophages (TAMs) massively, whose predominantly pro-tumor M2 phenotype leads to immunosuppression. Dihydroartemisinin (DHA) has been proven to remodel TAM into an anti-tumor M1 phenotype at certain c…
View article: Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery Open
The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showe…
View article: Integration of Genetic and Immune Infiltration Insights Into Data Mining of Multiple Sclerosis Pathogenesis
Integration of Genetic and Immune Infiltration Insights Into Data Mining of Multiple Sclerosis Pathogenesis Open
Background : Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Pathogenesis is closely related to environment, genetic and immune system, but the underlying interactions are still not clearl…
View article: Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor associated macrophages against tumor cells
Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor associated macrophages against tumor cells Open
Background: Tumor-associated macrophages (TAM) are the most abundant stromal cells in the tumor microenvironment. Turning the TAM against their host tumor cells is an intriguing therapeutic strategy particularly attractive for patients wit…
View article: Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment
Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment Open
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The tumor-associated macrophages (TAM) closely interact with the GBM cells (GC) to promote the survival, progression and therapy resistance of th…
View article: Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment
Exploiting the Cross-talk between Glioblastoma Cells and Tumor-associated Macrophages with a Nano-drug for regulating Tumor Immune Microenvironment Open
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The tumor-associated macrophages (TAM) closely interact with the GBM cells (GC) to promote the survival, progression and therapy resistance of th…
View article: Research on Identification Model of Financial Fraud of Listed Company Based on Data Mining Technology
Research on Identification Model of Financial Fraud of Listed Company Based on Data Mining Technology Open
Corporate financial information fraud is a difficult problem and a great hazard since the birth of the listed company system.The classic method of financial fraud detection is of high accuracy, but it requires enormous manpower and materia…
View article: Harnessing the Cross-talk between Tumor Cells and Tumor-associated Macrophages with a Nano-drug for modulation of Glioblastoma Immune Microenvironment
Harnessing the Cross-talk between Tumor Cells and Tumor-associated Macrophages with a Nano-drug for modulation of Glioblastoma Immune Microenvironment Open
Glioblastoma (GBM) is the most frequent and malignant brain tumor with a high mortality rate. The presence of a large population of macrophages (Mφ) in the tumor microenvironment is a prominent feature of GBM and these so-called tumor-asso…
View article: Advance in bioequivalence assessment of topical dermatological products
Advance in bioequivalence assessment of topical dermatological products Open
Bioequivalence (BE) assessment of topical dermatological products is a long standing challenge. The development of generic topical dermatological products has often been hampered due to the limited number of acceptable approaches, which ar…