X. Lucas Lu
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View article: Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan Integration
Decorin Promotes Nascent Proteoglycan Retention in Cartilage Matrix by Strengthening Collagen II-Aggrecan Integration Open
Cartilage extracellular matrix (ECM), a hydrated collagen II-aggrecan composite, undergoes dynamic turnover during both normal homeostasis and disease-associated remodeling. This study elucidates a crucial role for decorin in promoting the…
View article: M1 Macrophage-Derived Small Extracellular Vesicles as Synergistic Nanotherapeutics: Harnessing Intrinsic Anticancer Activity and Drug Delivery Capacity
M1 Macrophage-Derived Small Extracellular Vesicles as Synergistic Nanotherapeutics: Harnessing Intrinsic Anticancer Activity and Drug Delivery Capacity Open
Small extracellular vesicles (sEVs) have emerged as next-generation multifunctional nanotherapeutics due to their parental-cell traits and role in intercellular communication. Among them, immune cell–derived sEVs are uniquely positioned to…
View article: A dual attention and cross layer fusion network with a hybrid CNN and transformer architecture for medical image segmentation
A dual attention and cross layer fusion network with a hybrid CNN and transformer architecture for medical image segmentation Open
Medical image segmentation is a crucial technology for disease diagnosis and treatment planning. However, current approaches face challenges in capturing global semantic dependencies and integrating cross-layer features. While Convolutiona…
View article: Carbon nanotube analog tensor core accelerating edge computer vision
Carbon nanotube analog tensor core accelerating edge computer vision Open
Computer vision requires intense tensor operations, primarily matrix multiplications, imposing substantial computation demands. Using hardware such as GPU and ASICs for acceleration offers a viable solution. However, their application at e…
View article: Integrating digital image analysis, flash GC E-nose, and SHAP-driven interpretable deep learning for non-destructive aging assessment of citri reticulatae pericarpium
Integrating digital image analysis, flash GC E-nose, and SHAP-driven interpretable deep learning for non-destructive aging assessment of citri reticulatae pericarpium Open
This study proposes a novel non-destructive method for evaluating the aging time and quality of citri reticulatae pericarpium (CRP) by integrating digital image and flash gas chromatography electronic nose (GC E-nose). Digital imaging was …
View article: Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen
Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen Open
The pericellular matrix (PCM) is the immediate microniche surrounding cells in various tissues, regulating matrix turnover, cell‐matrix interactions, and disease. This study elucidates the structure‐mechanical properties and mechanobiology…
View article: Click chemistry-based quantification of extracellular matrix turnover for drug screening and regenerative medicine
Click chemistry-based quantification of extracellular matrix turnover for drug screening and regenerative medicine Open
This study presents a sensitive and cost-efficient method to quantify extracellular matrix (ECM) synthesis and degradation using copper-free click chemistry reactions to fluorescently label new ECM components. The approach enables spatial …
View article: Application of MRI image segmentation algorithm for brain tumors based on improved YOLO
Application of MRI image segmentation algorithm for brain tumors based on improved YOLO Open
Objective To assist in the rapid clinical identification of brain tumor types while achieving segmentation detection, this study investigates the feasibility of applying the deep learning YOLOv5s algorithm model to the segmentation of brai…
View article: Research on the Application of “AI Technology + Precision Medicine” in Ultrasound Intelligent Information Management Systems
Research on the Application of “AI Technology + Precision Medicine” in Ultrasound Intelligent Information Management Systems Open
This study explores the application of “AI Technology + Precision Medicine” in ultrasound intelligent information management systems, aiming to standardize and optimize medical processes and investigate methods for managing ultrasound diag…
View article: Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage
Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage Open
In osteoarthritis (OA), degradation of cartilage pericellular matrix (PCM), the proteoglycan-rich immediate cell microniche, is a leading event of disease initiation. This study demonstrated that biomimetic proteoglycans (BPGs) can diffuse…
View article: Durability test study of laminated specimens for large glass fiber protective structures in seawater
Durability test study of laminated specimens for large glass fiber protective structures in seawater Open
The mechanical properties of glass fiber composite structures prepared by vacuum forming manufacturing process are influenced by various factors and have a certain degree of dispersion, resulting in unclear durability characteristics when …
View article: Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen
Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen Open
The pericellular matrix (PCM) is the immediate microniche surrounding resident cells in various tissue types, regulating matrix turnover, cell-matrix cross-talk and disease initiation. This study elucidated the structure-mechanical propert…
View article: Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees
Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees Open
Knee osteoarthritis (OA), characterized by multiple joint tissue degenerations, remains a significant clinical challenge. Recent evidence suggests that crosstalk within the osteochondral unit may drive OA progression. Although structural-b…
View article: Triamcinolone acetonide has minimal effect on short‐ and long‐term metabolic activities of cartilage
Triamcinolone acetonide has minimal effect on short‐ and long‐term metabolic activities of cartilage Open
Intra‐articular corticosteroid injections, such as triamcinolone acetonide (TA), are commonly used by clinicians to manage joint synovial inflammation. However, due to conflicting evidence in literature, there is a fear among clinicians th…
View article: Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response
Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response Open
Purpose: In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how ma…
View article: Bat-derived oligopeptide LE6 inhibits the contact–kinin pathway and harbors anti-thromboinflammation and stroke potential.
Bat-derived oligopeptide LE6 inhibits the contact–kinin pathway and harbors anti-thromboinflammation and stroke potential. Open
Thrombosis and inflammation are primary contributors to the onset and progression of ischemic stroke. The contact-kinin pathway, initiated by plasma kallikrein (PK) and activated factor XII (FXIIa), functions bidirectionally with the coagu…
View article: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images
Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images Open
Electric fields find use in tissue engineering but also in sensor applications besides the broad classical application range. Accurate numerical models of electrical stimulation devices can pave the way for effective therapies in cartilage…
View article: Deriving Models of Cartilaginous Cells From Confocal Fluorescence Microscopy Images to Estimate Dielectric Properties
Deriving Models of Cartilaginous Cells From Confocal Fluorescence Microscopy Images to Estimate Dielectric Properties Open
The dielectric properties of cartilage are essential for the development of reliable numerical models of electrical stimulation devices intended for the regeneration of cartilage. They are, however, not widely known. To determine the diele…
View article: Data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images
Data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images Open
Replication data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images
View article: Data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images
Data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images Open
Replication data for: Contributions of deep learning to automated numerical modelling of the interaction of electric fields and cartilage tissue based on 3D images