Xinfeng Zhao
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View article: Assessing the Spatiotemporal Dynamics of Algal Communities in Urban Reservoirs: Influence of Reservoir Characteristics and River-reservoir Connectivity
Assessing the Spatiotemporal Dynamics of Algal Communities in Urban Reservoirs: Influence of Reservoir Characteristics and River-reservoir Connectivity Open
View article: Research Progress on Process Optimization of Metal Materials in Wire Electrical Discharge Machining
Research Progress on Process Optimization of Metal Materials in Wire Electrical Discharge Machining Open
Wire electrical discharge machining (WEDM), as a significant branch of non-traditional machining technologies, is widely applied in fields such as mold manufacturing and aerospace due to its high-precision machining capabilities for hard a…
View article: The application effect of rubber band traction assisted endoscopic submucosal dissection for esophageal precancerous lesions
The application effect of rubber band traction assisted endoscopic submucosal dissection for esophageal precancerous lesions Open
Objective: This study aimed to evaluate the efficacy of rubber band traction-assisted ESD (RBT-ESD) in treating esophageal precancerous lesions (EPLs). Methods: This retrospective cohort study included the clinical data of 110 patients wit…
View article: A framework for tracing the sources of nitrate in surface water through remote sensing data coupled with machine learning
A framework for tracing the sources of nitrate in surface water through remote sensing data coupled with machine learning Open
As an integral component of the global nitrogen cycle, nitrate are readily transferred from urban sewage discharge, agricultural activities, and atmospheric sedimentation to surface water. This paper introduces an innovative framework that…
View article: Precision Molding Simulation Study of 3D Ultra-Thin Glass Components for Smartwatches
Precision Molding Simulation Study of 3D Ultra-Thin Glass Components for Smartwatches Open
High stress and shape deviation during the glass forming process often led to low yield rates, posing a challenge in the production of high-precision smartwatch components. To address this issue, a numerical model was developed to simulate…
View article: Compress image to patches for Vision Transformer
Compress image to patches for Vision Transformer Open
The Vision Transformer (ViT) has made significant strides in the field of computer vision. However, as the depth of the model and the resolution of the input images increase, the computational cost associated with training and running ViT …
View article: A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs
A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs Open
View article: Seasonal Seawater Intrusion Alerting the Microbial Community and Mobile Antibiotic Resistance Gene Profiles in Estuary Water Revealed by Metagenomics
Seasonal Seawater Intrusion Alerting the Microbial Community and Mobile Antibiotic Resistance Gene Profiles in Estuary Water Revealed by Metagenomics Open
View article: Establishment and evaluation of haloalkane dehalogenase tagged <italic>α</italic><sub>1A</sub>-adrenergic receptor chromatography
Establishment and evaluation of haloalkane dehalogenase tagged <italic>α</italic><sub>1A</sub>-adrenergic receptor chromatography Open
Receptor chromatography is an efficient analytical technique that combines the high separation ability of chromatography with the high specificity of receptors for drug recognition. In addition, this technique offers the advantages of acti…
View article: A Comprehensive Review of Methods for Hydrological Forecasting Based on Deep Learning
A Comprehensive Review of Methods for Hydrological Forecasting Based on Deep Learning Open
Artificial intelligence has undergone rapid development in the last thirty years and has been widely used in the fields of materials, new energy, medicine, and engineering. Similarly, a growing area of research is the use of deep learning …
View article: Assessing the Spatiotemporal Dynamics of Algal Communities in Urban Reservoirs: Influence of Reservoir Characteristics and River-Reservoir Connectivity
Assessing the Spatiotemporal Dynamics of Algal Communities in Urban Reservoirs: Influence of Reservoir Characteristics and River-Reservoir Connectivity Open
View article: Progress in Active Infrared Imaging for Defect Detection in the Renewable and Electronic Industries
Progress in Active Infrared Imaging for Defect Detection in the Renewable and Electronic Industries Open
In recent years, infrared thermographic (IRT) technology has experienced notable advancements and found widespread applications in various fields, such as renewable industry, electronic industry, construction, aviation, and healthcare. IRT…
View article: Comprehensive genomic characterisation of the NAC transcription factor family and its response to drought stress in <i>Eucommia ulmoides</i>
Comprehensive genomic characterisation of the NAC transcription factor family and its response to drought stress in <i>Eucommia ulmoides</i> Open
The NAC transcription factor family enhances plant adaptation to environmental challenges by participating in signalling pathways triggered by abiotic stressors and hormonal cues. We identified 69 NAC genes in the Eucommia ulmoides genome …
View article: Development and Evaluation of a Novel Hyaluronic Acid andChitosan-modified Phytosome for Co-delivery of Oxymatrine andGlycyrrhizin for Combination Therapy
Development and Evaluation of a Novel Hyaluronic Acid andChitosan-modified Phytosome for Co-delivery of Oxymatrine andGlycyrrhizin for Combination Therapy Open
Background: Multidrug resistance (MDR) of cancer cells is a major obstacle to efficient cancer chemotherapy. Combination therapy is expected to enhance the anticancer effect and reverse MDR. Numerous patents involve different kinds of nano…
View article: <scp>N‐methyl‐D</scp>‐aspartic acid receptor <scp>2A</scp> functionalized stationary phase: A reliable method for pursuing potential ligands against Alzheimer's disease from natural products
<span>N‐methyl‐D</span>‐aspartic acid receptor <span>2A</span> functionalized stationary phase: A reliable method for pursuing potential ligands against Alzheimer's disease from natural products Open
Aims N‐methyl‐D‐aspartic acid (NMDA) receptors play subunit‐specific role in central neuronal development. However, insights into the pharmacological modulation of NMDA receptors were mainly lack of subunit and synaptic selectivity. The pu…
View article: Aptamer-assisted two-point immobilized agonist-bound angiotensin II type 1 receptor for a second-site modulator discovery
Aptamer-assisted two-point immobilized agonist-bound angiotensin II type 1 receptor for a second-site modulator discovery Open
View article: Early potential evaluation of lead compounds from a DNA-encoded library by the determination of their thermodynamics through a chromatographic method based on immobilized β2-adrenoceptor
Early potential evaluation of lead compounds from a DNA-encoded library by the determination of their thermodynamics through a chromatographic method based on immobilized β2-adrenoceptor Open
View article: Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library
Discovery of dual-target ligands binding to beta2-adrenoceptor and cysteinyl-leukotriene receptor for the potential treatment of asthma from natural products derived DNA-encoded library Open
View article: Revealing the Antiepileptic Effect of α-Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics
Revealing the Antiepileptic Effect of α-Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics Open
α-Asaronol from Acorus tatarinowii (known as "Shichangpu" in Traditional Chinese medicine) has been proved to possess more efficient antiepileptic activity and lower toxicity than α-asarone (namely "Xixinnaojiaonang" as an antiepile…
View article: Preparation and characterization of immobilized 5-HT1A receptor stationary phase for high throughput screening of the receptor-binding ligands from complex systems like Curcuma wenyujin Y. H. Chen et C. Ling extract
Preparation and characterization of immobilized 5-HT1A receptor stationary phase for high throughput screening of the receptor-binding ligands from complex systems like Curcuma wenyujin Y. H. Chen et C. Ling extract Open
View article: Semi-Quantitatively Predicting the Residence Times of Three Natural Products on Endothelin Receptor a by Peak Profiling Using the Receptor Functionalized Macroporous Silica Gel as Stationary Phase
Semi-Quantitatively Predicting the Residence Times of Three Natural Products on Endothelin Receptor a by Peak Profiling Using the Receptor Functionalized Macroporous Silica Gel as Stationary Phase Open
View article: Selective Discovery of GPCR Ligands within DNA-Encoded Chemical Libraries Derived from Natural Products: A Case Study on Antagonists of Angiotensin II Type I Receptor
Selective Discovery of GPCR Ligands within DNA-Encoded Chemical Libraries Derived from Natural Products: A Case Study on Antagonists of Angiotensin II Type I Receptor Open
Natural products have failed to meet the urgent need for drug discovery in recent decades due to limited resources, necessitating new strategies for re-establishing the key role of natural products in hit screening. This work introduced DN…
View article: Drug-Receptor Interaction Kinetics: A Case Study of Immobilized Endothelin Receptor A and Its Ligands
Drug-Receptor Interaction Kinetics: A Case Study of Immobilized Endothelin Receptor A and Its Ligands Open
View article: Early Evaluating Drug-Like Properties of Potential Compounds from DNA-Encoded Library by the Determination of their Thermodynamics through a Chromatographic Method Based on Immobilized β <sub>2</sub>-Adrenoceptor
Early Evaluating Drug-Like Properties of Potential Compounds from DNA-Encoded Library by the Determination of their Thermodynamics through a Chromatographic Method Based on Immobilized β <sub>2</sub>-Adrenoceptor Open
View article: Semi-Quantitatively Determining the Residence Time of Three Natural Products on Endothelin Receptor a by the Chromatographic Method Using the Immobilized Receptor as Stationary Phase
Semi-Quantitatively Determining the Residence Time of Three Natural Products on Endothelin Receptor a by the Chromatographic Method Using the Immobilized Receptor as Stationary Phase Open
View article: A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation Open
Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic c…
View article: Screening Bioactive Compounds of Siraitia grosvenorii by Immobilized β2-Adrenergic Receptor Chromatography and Druggability Evaluation
Screening Bioactive Compounds of Siraitia grosvenorii by Immobilized β2-Adrenergic Receptor Chromatography and Druggability Evaluation Open
As the first and key step of traditional Chinese medicine (TCM)-guided drug development, lead discovery necessitates continuous exploration of new methodology for screening bioactive compounds from TCM. This work intends to establish a str…
View article: Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation
Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation Open
Significance Obesity is associated with enhanced colonic inflammation, which is a major risk factor for colorectal cancer. To date, the mechanisms by which obesity increases colonic inflammation are not well-understood, and there are few e…
View article: Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo
Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo Open
Xinyi Yuan, Fuhuan Fei, Huanmei Sun, Chaoni Xiao, Xinfeng Zhao, Yajun Zhang, Xiaohui Zheng Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi&…
View article: One-step methodology for the direct covalent capture of GPCRs from complex matrices onto solid surfaces based on the bioorthogonal reaction between haloalkane dehalogenase and chloroalkanes
One-step methodology for the direct covalent capture of GPCRs from complex matrices onto solid surfaces based on the bioorthogonal reaction between haloalkane dehalogenase and chloroalkanes Open
An approach is established for the specific immobilization of GPCRs from cell lysates that circumvents labor intensive purification procedures and minimize loss of activity.