Xi-Qi Xu
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View article: Research progress on the role of oxidative stress in the pathogenesis of vascular dementia and its treatment
Research progress on the role of oxidative stress in the pathogenesis of vascular dementia and its treatment Open
The central role of oxidative stress in VaD provides new targets for treatment, but a shift from single-target antioxidant therapy to multi-level intervention is required. Future research should focus on developing targeted antioxidant the…
View article: Coronary artery stenosis associated with right ventricular dysfunction in acute pulmonary embolism: A case-control study
Coronary artery stenosis associated with right ventricular dysfunction in acute pulmonary embolism: A case-control study Open
Background: The potential impact of pre-existing coronary artery stenosis (CAS) on right ventricular (RV) function during acute pulmonary embolism (PE) episodes remains underexplored. This study aimed to investigate the association between…
View article: Burden of pulmonary arterial hypertension in Asia from 1990 to 2021: Findings from Global Burden of Disease Study 2021
Burden of pulmonary arterial hypertension in Asia from 1990 to 2021: Findings from Global Burden of Disease Study 2021 Open
Background: Pulmonary arterial hypertension (PAH) presents a significant health burden in Asia and remains a critical challenge. This study aims to delineate the PAH burden in Asia from 1990 to 2021. Methods: Using the latest data from the…
View article: Echocardiography combined with Mayo staging enhances the identification of early mortality risk in patients with light-chain cardiac amyloidosis
Echocardiography combined with Mayo staging enhances the identification of early mortality risk in patients with light-chain cardiac amyloidosis Open
Light-chain cardiac amyloidosis (AL-CA) is a fatal cardiomyopathy caused by the deposition of monoclonal immunoglobulin light-chain in the cardiac fibers, conduction system, valves, and other parts of the heart. Both Mayo 2004 and 2012 sta…
View article: Human Plasma Immunoglobulin G N-Glycome Profiles Reveal a Pro-Inflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension: A Cross-Sectional Study of Two Independent Cohorts
Human Plasma Immunoglobulin G N-Glycome Profiles Reveal a Pro-Inflammatory Phenotype in Chronic Thromboembolic Pulmonary Hypertension: A Cross-Sectional Study of Two Independent Cohorts Open
View article: Prevalence, Genetic Background, and Clinical Phenotype of Congenital Thrombophilia in Chronic Thromboembolic Pulmonary Hypertension
Prevalence, Genetic Background, and Clinical Phenotype of Congenital Thrombophilia in Chronic Thromboembolic Pulmonary Hypertension Open
View article: Association between Coronary Artery Stenosis and Myocardial Injury in Patients with Acute Pulmonary Embolism: A Case-Control Study
Association between Coronary Artery Stenosis and Myocardial Injury in Patients with Acute Pulmonary Embolism: A Case-Control Study Open
View article: Plasma metabolomics in perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease
Plasma metabolomics in perioperative period of defect repair in patients with pulmonary arterial hypertension associated with congenital heart disease Open
Background The pathophysiological alterations in response to shunt correction in patients with pulmonary arterial hypertension associated with congenital heart disease (CHD-PAH) is still not clear. Purpose To explore the dynamic plasma met…
View article: Standard Operation Procedure of Percutaneous Endomyocardial Biopsy in Peking Union Medical College Hospital
Standard Operation Procedure of Percutaneous Endomyocardial Biopsy in Peking Union Medical College Hospital Open
Percutaneous endomyocardial biopsy (EMB) is a technique that biopsy samples are obtained using bioptome through peripheral blood vessel. This technique has been used and refined more than 50 years in clinical application. Now EMB has becom…
View article: Association Between Anticoagulation Outcomes and Venous Thromboembolism History in Chronic Thromboembolic Pulmonary Hypertension
Association Between Anticoagulation Outcomes and Venous Thromboembolism History in Chronic Thromboembolic Pulmonary Hypertension Open
Background: The association between anticoagulation outcomes and prior history of venous thromboembolism (VTE) in chronic thromboembolic pulmonary hypertension (CTEPH) has not been established. This study aimed to compare the efficacy and …
View article: Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension
Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension Open
Background: Superoxide dismutases (SODs) are an important family of antioxidant enzymes that modulate reactive oxygen species levels. It is largely unknown which SOD isoform(s) change in vivo in idiopathic pulmonary arterial …
View article: Association of Rare <i>PTGIS</i> Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension
Association of Rare <i>PTGIS</i> Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension Open
This study identified 3 rare loss-of-function variants in the PTGIS gene from 2 independent cohorts with IPAH. The genetic variants of PTGIS predispose pulmonary vascular responses to the iloprost stimulation. These findings suggest that P…
View article: When REVEAL meets AMBITION, does it reveal more?
When REVEAL meets AMBITION, does it reveal more? Open
View article: Supplementary Material for: Human Cervical Epithelial Cells Release Antiviral Factors and Inhibit HIV Replication in Macrophages
Supplementary Material for: Human Cervical Epithelial Cells Release Antiviral Factors and Inhibit HIV Replication in Macrophages Open
The female reproductive tract is a major site of HIV sexual transmission. We here examined whether human cervical epithelial cells (HCEs) can be immunologically activated and produce antiviral factors against HIV. We demonstrated that HCEs…