Xinghao Yu
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View article: Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation
Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation Open
Regulatory T cells (Tregs) orchestrate immune tolerance, protecting against autoimmunity and promoting transplant tolerance, yet they can also facilitate tumor immune evasion. Advances in nanotechnology now permit high‐precision manipulati…
View article: Commensal <i>Bacteroides</i> T6SS alleviate GI-aGVHD via mediating gut microbiota composition and bile acids metabolism
Commensal <i>Bacteroides</i> T6SS alleviate GI-aGVHD via mediating gut microbiota composition and bile acids metabolism Open
Background Gastrointestinal acute graft-versus-host disease (GI-aGVHD) is one of the main complications of patients undergoing allogenic haematopoietic stem cell transplantation (allo-HSCT). A deeper understanding of the mechanisms of sust…
View article: Poor sleep and high rheumatoid arthritis risk: Evidence from large UK Biobank cohort
Poor sleep and high rheumatoid arthritis risk: Evidence from large UK Biobank cohort Open
Objective To evaluate the relationship between sleep behaviors and rheumatoid arthritis (RA) risk. Methods First, based on large-scale data from the UK Biobank, we analyzed the associations between multiple sleep factors and RA risk and ca…
View article: Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse
Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse Open
Our findings provide novel insights into the metabolic mechanisms underlying GVHD and relapse after allo-HSCT. Identified metabolites, particularly pyridoxate, may serve as potential therapeutic targets for GVHD prevention and management.
View article: The Causal Association Between Blood Metabolites and Ovarian Cancer: Mendelian Randomization Study
The Causal Association Between Blood Metabolites and Ovarian Cancer: Mendelian Randomization Study Open
Objective: Ovarian cancer is closely related to human metabolism, but the causal effect of serum metabolites on its occurrence and development is still unknown. Methods: Based on the publicly available Genome-Wide Association Studies (GWAS…
View article: Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality
Association between 25(OH) vitamin D and multiple sclerosis: cohort, shared genetics, and Causality Open
View article: Causal Effects of Sarcopenia-related Traits on Ischemic Stroke: A Two-sample Mendelian Randomization Study
Causal Effects of Sarcopenia-related Traits on Ischemic Stroke: A Two-sample Mendelian Randomization Study Open
Objective: The stroke itself can cause sarcopenia, loss of muscle, and weaker strength is commonly experienced in some patients after ischemic stroke. However, the causal effect of sarcopenia on stroke is unclear, and previous studies focu…
View article: Inflammatory bowel disease and osteoporosis: Common genetic effects, pleiotropy, and causality
Inflammatory bowel disease and osteoporosis: Common genetic effects, pleiotropy, and causality Open
Our study indicates that IBD may increase the risk of OP and reveals a complex genetic mechanism linking IBD and the risk of osteoporosis, which has important implications for diagnosing and treating IBD and OP.
View article: Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis
Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis Open
View article: Referee report. For: A genome-wide association study of childhood adiposity and blood lipids [version 2; peer review: 1 approved, 2 approved with reservations]
Referee report. For: A genome-wide association study of childhood adiposity and blood lipids [version 2; peer review: 1 approved, 2 approved with reservations] Open
View article: Causal effects and immune cell mediators between prescription analgesic use and risk of infectious diseases: a Mendelian randomization study
Causal effects and immune cell mediators between prescription analgesic use and risk of infectious diseases: a Mendelian randomization study Open
Introduction Clinical observations have found that prolonged use of analgesics increases the incidence of infection. However, the direct causal relationship between prescription analgesic use (PAU) and risk of infection (ROI) remains uncle…
View article: Poor sleep behaviors and high genetic susceptibility increase the risk of osteoarthritis
Poor sleep behaviors and high genetic susceptibility increase the risk of osteoarthritis Open
Background Emerging research evidence suggests an association between sleep behaviors and the risk of osteoarthritis. The various sleep behaviors are typically correlated; however, most previous studies have focused on a particular sleep b…
View article: Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank
Air pollution, genetic factors and the risk of osteoporosis: A prospective study in the UK biobank Open
Purpose To reveal relationship between air pollution exposure and osteoporosis (OP) risk. Methods Based on large-scale data from the UK Biobank, we evaluated the relationship between OP risk and several air pollutants. Then air pollution s…
View article: Efficient feature extraction from highly sparse binary genotype data for cancer prognosis prediction using an auto-encoder
Efficient feature extraction from highly sparse binary genotype data for cancer prognosis prediction using an auto-encoder Open
Genomics involving tens of thousands of genes is a complex system determining phenotype. An interesting and vital issue is how to integrate highly sparse genetic genomics data with a mass of minor effects into a prediction model for improv…
View article: The immune factors have complex causal regulation effects on bone mineral density
The immune factors have complex causal regulation effects on bone mineral density Open
Recent evidence has gradually recognized that the immune and skeletal systems are two closely correlated systems, but the specific immune factors on bone mineral density (BMD) are largely unknown. Based on the summary-level data of genome-…
View article: Effects of Acetylated Glucocorticoid Receptor and Histone 3/Histone 4 on Glucocorticoid Response in Children Patients with Primary Nephrotic Syndrome
Effects of Acetylated Glucocorticoid Receptor and Histone 3/Histone 4 on Glucocorticoid Response in Children Patients with Primary Nephrotic Syndrome Open
Introduction : Glucocorticoid (GC) response resistance is considered a poor prognostic indicator but the mechanism of the resistance remains unknown. We explored the possible reasons from an epigenetic perspective. Methods The glucocortico…
View article: Genetic Risk for Osteoporosis and the Benefit of Adherence to Healthy Lifestyles
Genetic Risk for Osteoporosis and the Benefit of Adherence to Healthy Lifestyles Open
Objectives: We aimed to explore how healthy lifestyles and genetic factors influence the risk of Osteoporosis (OP). Methods: In this prospective cohort study, we first performed a genome-wide association study (GWAS) of estimated bone mine…
View article: Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization
Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization Open
Purpose Osteoporosis is associated with metabolic alterations, but the causal roles of serum metabolites on osteoporosis have not been identified. Methods Based on the large individual-level datasets from UK Biobank as well as GWAS summary…
View article: Efficient Feature Extraction from High Sparse Binary Genotype Data for Genetic Risk Prediction by Deep Learning Method
Efficient Feature Extraction from High Sparse Binary Genotype Data for Genetic Risk Prediction by Deep Learning Method Open
Genomics involving tens of thousands of genes is a complex system determining phenotype. An interesting and vital issue is that how to integrate highly sparse genetic genomics data with a mass of minor effects into prediction model for imp…
View article: Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores
Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores Open
Background Effective identification of high-risk rheumatoid arthritis (RA) individuals is still a challenge. Whether the combined effects of multiple previously reported genetic loci together with lifestyle factors can improve the predicti…
View article: Exosomal miRNA Profiling to Identify Nanoparticle Phagocytic Mechanisms
Exosomal miRNA Profiling to Identify Nanoparticle Phagocytic Mechanisms Open
Small 2018, 14, 1704008 DOI: 10.1002/smll.201704008 In the originally published article, the image of the fibroblast in Figure 7D (P1 group) was presented incorrectly. Herein, the correct version of Figure 7D is presented. The authors stat…
View article: Novel Autophagy-Related Gene Signature Investigation for Patients With Oral Squamous Cell Carcinoma
Novel Autophagy-Related Gene Signature Investigation for Patients With Oral Squamous Cell Carcinoma Open
The correlation between autophagy defects and oral squamous cell carcinoma (OSCC) has been previously studied, but only based on a limited number of autophagy-related genes in cell lines or animal models. The aim of the present study was t…
View article: Supplement to "Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization"
Supplement to "Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization" Open
对“血液代谢产物对骨质疏松症的因果关系进行系统评估：遗传风险评分和孟德尔随机化”的增刊
View article: Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Healthy Lifestyles and Polygenic Risk Score: Large Case-Control and Prospective Cohort Studies
Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Healthy Lifestyles and Polygenic Risk Score: Large Case-Control and Prospective Cohort Studies Open
View article: Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies
Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies Open
The relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based o…
View article: Leveraging Methylation Alterations to Discover Potential Causal Genes Associated with the Survival Risk of Cervical Cancer in TCGA through a Two-stage Inference Approach
Leveraging Methylation Alterations to Discover Potential Causal Genes Associated with the Survival Risk of Cervical Cancer in TCGA through a Two-stage Inference Approach Open
Background：Multiple genes were previously identified to be associated with cervical cancer; however, the genetic architecture of cervical cancer remains unknown and many causal genes have yet been discovered.Methods: To explore causal gene…
View article: How Can Gene-Expression Information Improve Prognostic Prediction in TCGA Cancers: An Empirical Comparison Study on Regularization and Mixed Cox Models
How Can Gene-Expression Information Improve Prognostic Prediction in TCGA Cancers: An Empirical Comparison Study on Regularization and Mixed Cox Models Open
This study demonstrates that the integration of transcriptomic information can substantially improve prognostic prediction accuracy, but the prediction performance is cancer-specific and varies across cancer types. It further reveals that …
View article: Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis
Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis Open
View article: Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets
Birth Weight and Stroke in Adult Life: Genetic Correlation and Causal Inference With Genome-Wide Association Data Sets Open
This study provides empirically supportive evidence on the fetal developmental origins of stroke and its subtypes. However, further investigation is warranted to understand the pathophysiological role of low birth weight in developing stro…
View article: Relationship between birth weight and chronic kidney disease: evidence from systematics review and two-sample Mendelian randomization analysis
Relationship between birth weight and chronic kidney disease: evidence from systematics review and two-sample Mendelian randomization analysis Open
Observational studies showed an inverse association between birth weight and chronic kidney disease (CKD) in adulthood existed. However, whether such an association is causal remains fully elusive. Moreover, none of prior studies distingui…