Xuefei Zhao
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View article: Mechanistic insights into how g protein-coupled receptor kinases (GRKs) regulate thrombopoiesis
Mechanistic insights into how g protein-coupled receptor kinases (GRKs) regulate thrombopoiesis Open
Platelet disorders encompass abnormalities in platelet function as well as alterations in platelet counts, including thrombocytopenia and thrombocythemia. Patients with these disorders are at an increased risk of hemorrhage or thrombosis. …
View article: HTRS2025.O6A.6 Reduced Thrombin-Mediated Platelet Activation is a Major Contributor to Impaired Hemostasis in Settings of Coagulation Deficiency
HTRS2025.O6A.6 Reduced Thrombin-Mediated Platelet Activation is a Major Contributor to Impaired Hemostasis in Settings of Coagulation Deficiency Open
View article: The Impact of Environmental Incentive Policies on the Value of New Energy Enterprises—Evidence from China’s New Energy Demonstration Cities
The Impact of Environmental Incentive Policies on the Value of New Energy Enterprises—Evidence from China’s New Energy Demonstration Cities Open
The world is facing increasingly severe environmental challenges, making the development of new energy a crucial trend for the future. The corporate value of new energy enterprises plays a vital role in their sustainable growth. Current en…
View article: Optimized Plant Configuration Designs for Wind Damage Prevention in Masonry Heritage Buildings: A Case Study of Zhen Guo Tower in Weihui, Henan, China
Optimized Plant Configuration Designs for Wind Damage Prevention in Masonry Heritage Buildings: A Case Study of Zhen Guo Tower in Weihui, Henan, China Open
Wind-induced erosion and extreme weather events pose growing risks to the structural integrity of masonry heritage buildings. However, current mitigation approaches often overlook ecological sustainability. This study investigates the wind…
View article: Multifunctional Prussian lue nanozymes ameliorate tendinopathy via modulating tissue homeostasis
Multifunctional Prussian lue nanozymes ameliorate tendinopathy via modulating tissue homeostasis Open
Tendinopathy, a prevalent musculoskeletal disorder characterized by chronic pain and functional decline, remains a therapeutic challenge due to the limited efficacy of conventional treatments in addressing oxidative stress and persistent i…
View article: Understanding the interplay between COVID-19 and diabetes: insights for the post-pandemic era
Understanding the interplay between COVID-19 and diabetes: insights for the post-pandemic era Open
The global pandemic caused by the SARS-CoV-2 virus has had a profound impact on the onset, progression, and management of diabetes, posing significant challenges to healthcare systems worldwide. This review elucidates the multifaceted impa…
View article: X26nt-mediated recruitment of eIF4A2 facilitates CCND1 translation to drive endothelial cell cycle progression
X26nt-mediated recruitment of eIF4A2 facilitates CCND1 translation to drive endothelial cell cycle progression Open
View article: Inversion and analysis of leaf area index (LAI) of urban park based on unmanned aerial vehicle (UAV) multispectral remote sensing and random forest (RF)
Inversion and analysis of leaf area index (LAI) of urban park based on unmanned aerial vehicle (UAV) multispectral remote sensing and random forest (RF) Open
Leaf Area Index (LAI) is a critical indicator of vegetation growth and ecological function. Unlike the relatively uniform crop types and planting methods typically found in agricultural fields, parks typically feature a diverse range of pl…
View article: Dynamic Analysis of Dual Parallel Spring-Supported Tilting Pad Journal Bearing
Dynamic Analysis of Dual Parallel Spring-Supported Tilting Pad Journal Bearing Open
The elastic-supported tilting pad journal bearing brings new momentum and opportunities for improving the lubrication performance and dynamic stability of high-speed bearing–rotor systems. The objective of this study is to investigate the …
View article: Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity
Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity Open
Platelets are enriched in miRNAs and harbor Ago2 as the principal RNA silencing Argonaute. However, roles in thrombopoiesis and platelet function remain poorly understood. We generated megakaryocyte/platelet-specific Ago2-deleted (Ago2 KO)…
View article: Green finance, technological innovation, and low-carbon development in logistics industry: mechanisms and threshold effects
Green finance, technological innovation, and low-carbon development in logistics industry: mechanisms and threshold effects Open
View article: Water oxidation to H <sub>2</sub> O <sub>2</sub> on surface-modified carbon cloth electrodes
Water oxidation to H <sub>2</sub> O <sub>2</sub> on surface-modified carbon cloth electrodes Open
PVDF-modified carbon cloth enables efficient H 2 O 2 production via carbonate-mediated water oxidation with 91% faradaic efficiency.
View article: Molecular Cloning of QwMYB108 Gene and Its Response to Drought Stress in Quercus wutaishanica Mayr
Molecular Cloning of QwMYB108 Gene and Its Response to Drought Stress in Quercus wutaishanica Mayr Open
Drought is a significant environmental limiting factor that restricts the growth of Quercus wutaishanica Mayr. The MYB transcription factor plays a wide role in controlling the growth of plants. In this study, the QwMYB108 gene was cloned …
View article: Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities
Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities Open
Importance Previous studies have shown that Jinlida (JLD) granules, an approved treatment for type 2 diabetes in China, can reduce blood glucose level, reduce glycated hemoglobin (HbA 1c ), and improve insulin resistance in people with typ…
View article: Early effective intervention can significantly reduce all-cause mortality in prediabetic patients: a systematic review and meta-analysis based on high-quality clinical studies
Early effective intervention can significantly reduce all-cause mortality in prediabetic patients: a systematic review and meta-analysis based on high-quality clinical studies Open
Background Reducing the occurrence of diabetes is considered a primary criterion for evaluating the effectiveness of interventions for prediabetes. There is existing evidence that early lifestyle-based interventions can significantly decre…
View article: Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy
Parallelism and non-parallelism in diabetic nephropathy and diabetic retinopathy Open
Diabetic nephropathy (DN) and diabetic retinopathy (DR), as microvascular complications of diabetes mellitus, are currently the leading causes of end-stage renal disease (ESRD) and blindness, respectively, in the adult working population, …
View article: Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential
Plasma growth factors maintain constitutive translation in platelets to regulate reactivity and thrombotic potential Open
Mechanisms of proteostasis in anucleate circulating platelets are unknown and may regulate platelet function. We investigated the hypothesis that plasma–borne growth factors/hormones (GFHs) maintain constitutive translation in circulating …
View article: Dual antithrombotic therapy dose-dependently alters hemostatic plug structure and function
Dual antithrombotic therapy dose-dependently alters hemostatic plug structure and function Open
View article: Pyroptosis: the dawn of a new era in endometrial cancer treatment
Pyroptosis: the dawn of a new era in endometrial cancer treatment Open
Endometrial cancer (EC) is a malignancy of the inner epithelial lining of the uterus. While early-stage EC is often curable through surgery, the management of advanced, recurrent and metastatic EC poses significant challenges and is associ…
View article: OC 61.5 Plasma Growth Factors Drive Constitutive Translation in Circulating Platelets to Maintain Protein Homeostasis and Regulate Platelet GPCR Reactivity and the Hemostatic and Thrombotic Balance
OC 61.5 Plasma Growth Factors Drive Constitutive Translation in Circulating Platelets to Maintain Protein Homeostasis and Regulate Platelet GPCR Reactivity and the Hemostatic and Thrombotic Balance Open
Background: Increased levels of the circulating form of human endoglin (sEng) have been reported in several cardiovascular-related conditions including preeclampsia, as a consequence of a cleavage product of membrane bound endoglin, presen…
View article: PB0403 A Common Variant in GRK5 Reveals a PAR1-Specific Regulation in Platelets
PB0403 A Common Variant in GRK5 Reveals a PAR1-Specific Regulation in Platelets Open
Fig. 1).Platelet spreading to fibrinogen was found significantly decreased in PT-DKO compared to WT.
View article: OC 14.3 A Novel Strategy to Combat the Procoagulant Phenotype in Immune Thrombotic Thrombocytopenia using 12-LoX Inhibition
OC 14.3 A Novel Strategy to Combat the Procoagulant Phenotype in Immune Thrombotic Thrombocytopenia using 12-LoX Inhibition Open
Background: Immune thrombotic thrombocytopenia (ITT) disorders, including heparin-induced thrombocytopenia (HIT), are caused by IgG immune complexes that activate platelets through Fc Receptor for IgG IIA (FcγRIIA).ITTs, characterized by p…
View article: A regulatory node involving Gαq, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists
A regulatory node involving Gαq, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists Open
View article: Separation and thermal conversion of group components from medium‐low‐temperature coal tar pitch
Separation and thermal conversion of group components from medium‐low‐temperature coal tar pitch Open
Medium‐low‐temperature coal tar pitch (MLP) is a complex mixture of varied heavy organic hydrocarbons, which was generally used as the raw materials to produce artificial carbon materials. It was great significance for the high value‐added…
View article: Isolation of phosphorus-hyperaccumulating microalgae from revolving algal biofilm (RAB) wastewater treatment systems
Isolation of phosphorus-hyperaccumulating microalgae from revolving algal biofilm (RAB) wastewater treatment systems Open
Excess phosphorus (P) in wastewater effluent poses a serious threat to aquatic ecosystems and can spur harmful algal blooms. Revolving algal biofilm (RAB) systems are an emerging technology to recover P from wastewater before discharge int…
View article: Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy
Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy Open
Diabetic peripheral neuropathy (DPN) is a chronic and prevalent metabolic disease that gravely endangers human health and seriously affects the quality of life of hyperglycemic patients. More seriously, it can lead to amputation and neurop…
View article: Adsorption of crystal violet on activated bamboo fiber powder from water: preparation, characterization, kinetics and isotherms
Adsorption of crystal violet on activated bamboo fiber powder from water: preparation, characterization, kinetics and isotherms Open
Waste bamboo fiber was obtained from the paper-making industry, and bamboo fiber-activated carbon was prepared by employing the KOH activation method. The bamboo fiber-activated carbon was used as the absorbent to absorb the crystal violet…
View article: Renoprotective Effects of Angiotensin-Converting Enzyme Inhibitors (Acei) And/Or Angiotensin Ii Receptor Blockers (Arb) in Diabetic Kidney Disease
Renoprotective Effects of Angiotensin-Converting Enzyme Inhibitors (Acei) And/Or Angiotensin Ii Receptor Blockers (Arb) in Diabetic Kidney Disease Open
View article: Preparation and Characterization of Mesocarbon Microbeads by the Co-Polycondensation of High-Temperature Coal Tar Pitch and Coal Pyrolytic Extracts
Preparation and Characterization of Mesocarbon Microbeads by the Co-Polycondensation of High-Temperature Coal Tar Pitch and Coal Pyrolytic Extracts Open
Mesocarbon microbeads (MCMBs) are a kind of engineering and functional artificial carbon materials generally prepared by the polymerization of polycyclic aromatic hydrocarbons. The physicochemical property of the raw materials plays a key …
View article: GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12
GRK2 regulates ADP signaling in platelets via P2Y1 and P2Y12 Open
The critical role of G protein–coupled receptor kinase 2 (GRK2) in regulating cardiac function has been well documented for >3 decades. Targeting GRK2 has therefore been extensively studied as a novel approach to treating cardiovascular…