Explanipedia

Role of S1PR1 in VEGF-exosomes mediated resistance of hepatocellular carcinoma to anti-angiogenesis therapy Open

Xinghong Yao, Min Tang, Liang Li, Ye Zeng · 2025

Spatial confinement modulates endothelial cell behavior and traction force in 3D hydrogel microgrooves Open

Wenli Jiang, Xinghong Yao, Jian Zhong, Zhi Ouyang, Junyi Shen , et al. · 2024

Advances in Regulating Cellular Behavior UsingMicropatterns Open

Yizhou Li, Wen‐Li Jiang, Xintong Zhou, Yicen Long, Yujia Sun , et al. · 2023

Micropatterns, characterized as distinct physical microstructures or chemical adhesion matrices on substance surfaces, have emerged as a powerful tool for manipulating cellular activity. By creating specific extracellular matrix microenvir…

Comparing breath hold versus free breathing irradiation for left-sided breast radiotherapy by PlanIQ™ Open

Ke Yuan, Xinghong Yao, Xiongfei Liao, Pen Diao, Xin Xin , et al. · 2023

Background Breast cancer is the most widespread cancer in women and young women worldwide. Moving towards customised radiotherapy, balancing the use of the available technology with the best treatment modality may not be an easy task in th…

Study on Lattice Radiotherapy Treatments (LRT) for Head and Neck Bulky Tumors Open

Kun Yuan, Xiaoyan Liao, Xinghong Yao, M. Liu, Peng Xu , et al. · 2023

Effectiveness of bladder filling control during online MR-guided adaptive radiotherapy for rectal cancer Open

Xi Feng, Bin Tang, Xinghong Yao, Min Liu, Xiongfei Liao , et al. · 2023

Tumour associated endothelial cells: origin, characteristics and role in metastasis and anti-angiogenic resistance Open

Xinghong Yao, Ye Zeng · 2023

Tumour progression and metastasis remain the leading causes of cancer-related death worldwide. Tumour angiogenesis is essential for tumour progression. The vasculature surrounding tumours is not only a transport channel for nutrients, oxyg…

Improving the clinical workflow of a MR-Linac by dosimetric evaluation of synthetic CT Open

Bin Tang, Min Liu, Bingjie Wang, Peng Diao, Jie Li , et al. · 2022

Adaptive radiotherapy performed on the daily magnetic resonance imaging (MRI) is an option to improve the treatment quality. In the adapt-to-shape workflow of 1.5-T MR-Linac, the contours of structures are adjusted on the basis of patient …

Biological Features of Extracellular Vesicles and Challenges Open

Ye Zeng, Yan Qiu, Wen‐Li Jiang, Junyi Shen, Xinghong Yao , et al. · 2022

Extracellular vesicles (EVs) are vesicles with a lipid bilayer membrane on the outside, which are widely found in various body fluids and contain biological macromolecules such as DNA, RNA, lipids and proteins on the inside. EVs were once …

Cyclic biaxial tensile strain enhances osteogenic differentiation in rat bone marrow-derived mesenchymal stem cells via activating ERα-Wnt3a/β-catenin pathway Open

Min Tang, Xueling He, Xinghong Yao, Jirui Wen, Mingyue Bao , et al. · 2022

The present study was designed to investigate the role of estrogen receptor α (ERα) in biaxial tensile strain (BTS) regulated osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs). rBMSCs were derived from r…

Single-cell RNA sequencing reveals classical monocytes are the major precursors of rat osteoclasts Open

Jirui Wen, Wenchao Wu, Min Tang, Mingyue Bao, Xueling He , et al. · 2021

To dissect which subset of bone marrow monocyte is the major precursor of osteoclast, 3-month-old rat bone marrow was obtained for single-cell RNA sequencing. A total of 6091 cells were acquired for detailed analysis, with a median number …

Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats Open

Jirui Wen, Mingyue Bao, Min Tang, Xueling He, Xinghong Yao , et al. · 2021

Dysfunction of bone marrow mesenchymal stem cells (BMSCs), osteoblasts and osteocytes may be one of the main causes of bone loss in the elderly. In the present study, we found osteogenic cells from aged rats all exhibited senescence change…

Identification of a 9-gene signature related to stemness for prognosis in hepatocellular carcinoma basing on weighted gene coexpression network analysis Open

Xinghong Yao, Chengquan Lu, Qidi Pang, Ye Zeng · 2021

Background Cancer stem cells (CSCs) are heterogeneous with self-renewal and differentiation ability. The mRNA expression-based stemness index (mRNAsi) described the similarity between tumor cells and CSCs, which is positively associated wi…

A novel nine gene signature integrates stemness characteristics associated with prognosis in hepatocellular carcinoma Open

Xinghong Yao, Chengquan Lu, Junyi Shen, Wen‐Li Jiang, Yan Qiu , et al. · 2021

Cancer stem cells (CSCs) are heterogeneous with self-renewal and differentiation ability. The mRNA expression-based stemness index (mRNAsi) described the similarity between tumor cells and CSCs, which is positively associated... | Find, re…

Retrospective Study on Left-Sided Breast Radiotherapy: Dosimetric Results and Correlation with Physical Factors for Free Breathing and Breath Hold Irradiation Techniques Open

Xin Xin, Jie Li, Yanqun Zhao, Pei Wang, Bin Tang , et al. · 2021

Objectives: In breast radiotherapy, the proximity of the target to sensitive structures together with the uncertainty introduced by respiratory movement, make this treatment one of the most studied to increase its effectiveness. Dosimetric…

MiR-9 Promotes Angiogenesis via Targeting on Sphingosine-1- Phosphate Receptor 1 Open

Xinghong Yao, Linshen Xie, Ye Zeng · 2020

We previously demonstrated that vascular endothelial cells released VEGF-enriched exosomes to promote the tumor vasculogenesis and progression after anti-angiogenic therapies (AATs). To clarify how microRNA (miR)-9 promoted the angiogenesi…

Impact of positioning errors in the dosimetry of VMAT left-sided post mastectomy irradiation Open

Xiongfei Liao, Fan Wu, Junxiang Wu, Qian Peng, Xinghong Yao , et al. · 2020

Background Volumetric modulated arc therapy (VMAT) adopted in post-mastectomy radiation therapy (PMRT) has the capacity to achieve highly conformal dose distributions. The research aims to evaluate the impact of positioning errors in the d…

Effectiveness of a 2D-Transit Epid-Based in-Vivo Dosimetry System in Highlighting the Accuracy of Target Dose Coverage for Post-Mastectomy VMAT Irradiation Open

Xiaoli Liao, J. Li, Sang Koo Kang, Bin Tang, Xinghong Yao , et al. · 2019

Anti‐angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis Open

Ye Zeng, Xinghong Yao, Xiaoheng Liu, Xueling He, Liang Li , et al. · 2019

Although anti‐angiogenic therapies (AATs) have some effects against multiple malignancies, they are limited by subsequent tumor vasculogenesis and progression. To investigate the mechanisms by which tumor vasculogenesis and progression fol…

A Robust Deep Learning Approach for Automatic Classification of Seizures Against Non-seizures Open

Xinghong Yao, X. Li, Q. Ye, Yan Huang, Qiang Cheng , et al. · 2018

Identifying epileptic seizures through analysis of the electroencephalography (EEG) signal becomes a standard method for the diagnosis of epilepsy. Manual seizure identification on EEG by trained neurologists is time-consuming, labor-inten…

Feasibility of a Skin Dose Reduction for Nasopharyngeal Carcinoma Treated With High-Intensity-Modulated Delivery Techniques Open

Xiongfei Liao, Jie Li, Pei Wang, Xinghong Yao, Zhang Yulei , et al. · 2018

Acute skin toxicity observed in radiotherapy treatment of head and neck cancer is a big concern. The purpose of this work is to evaluate the feasibility of a skin dose reduction in the treatment of nasopharyngeal carcinoma without compromi…

Comparative Analysis of the Effective Dose in Craniospinal Irradiation of Pediatric Patients Between Helical Tomotherapy and Multi-Isocenter Intensity Modulated Radiation Therapy Open

P. Wang, Y. Chen, L.C. Orlandini, Xinghong Yao, J. Li , et al. · 2017

Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-β autocrine loop Open

Ye Zeng, Xinghong Yao, Li Chen, Zhiping Yan, Jingxia Liu , et al. · 2016

Sphingosine-1-phosphate (S1P) induces epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma (HCC). However, its underlying mechanism remains largely unknown. In the present study, we investigated the correlation between S1P a…

Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer Open

Ye Zeng, Xinghong Yao, Zhiping Yan, Jingxia Liu, Xiaoheng Liu · 2016

The developmental process of epithelial-mesenchymal transition (EMT) occurs when epithelial cells acquire invasive mesenchymal cell characteristics, and the activation of this process has been indicated to be involved in tumor progression.…

Potential microRNA biomarkers for acute ischemic stroke Open

Ye Zeng, Jingxia Liu, Zhiping Yan, Xinghong Yao, Xiaoheng Liu · 2015

Acute ischemic stroke is a significant cause of high morbidity and mortality in the aging population globally. However, current therapeutic strategies for acute ischemic stroke are limited. Atherosclerotic plaque is considered an independe…

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